Epidemiology, pathogenesis and diagnostics of cancer

A.Y. 2018/2019
Overall hours
MED/01 MED/04 MED/06 MED/15
Learning objectives
The training course aims to transfer to the students the basic knowledge of tumors pathogenesis and diagnosis, with particular reference to the development of the epidemiology, pathology and medical genetics notions and their applications to the diagnosis and therapy of tumors.
In particular:
- Comprehension of the frequency and distribution of tumors and the environment influence on tumor
- Concepts of cancer stem cells, their biology, functional pathways, involved genes and their instability
- Concepts of solid tumors and hematological malignancies, their biology, and the molecular diagnostics applied to their assessment.
Expected learning outcomes
Epidemiology of cancer
Molecular mechanisms of cancer pathogenesis
Alteration of cancer cell biology
Molecular classification of solid and hematological tumors
Approaches for diagnosis of solid and hematological tumors
Course syllabus and organization

Single session

Lesson period
Third trimester
Medical statistics
Course syllabus
Patterns and trends of cancer mortality in Europe.
Tobacco and cancer risk.
Alcohol and cancer.
Other environmental risk factors of cancer, including nutrition and diet.
General pathology and immunology
Course syllabus
Cancer Stem Cells:
Identification and origins. Biologic characteristic of cancer stem cells. Cancer stem cell niches. Regulation of cancer stem cells by the tumor microenvironment and cytokine networks.
Cancer cell growth: nutrient regulation, control of tumor growth and metabolism, pathways that control cell growth, es. mTOR.
Autophagy: Autophagy-mediated tumor suppression; tumor promotion by autophagy; role of autophagy in cancer therapy.
Cellular Senescence: Biochemical and morphological characteristics of senescent cells; causes of senescence; premature senescence. Major pathways regulating senescence. Tumor promoting and tumor suppressing activity of senescence-associated secretory phenotype.
Medical Oncology
Course syllabus
Molecular pathogenesis, natural hystory and diagnostic/prognostic assessment of solid tumors
Blood diseases
Course syllabus
Molecular and biological mechanisms of acute and chronic myeloid disorders. Diagnostic tools- Concept of risk stratification
Molecular and biological mechanisms of lymphoproliferative disorders. Diagnostic tools- Concept of risk stratification
Blood diseases
MED/15 - BLOOD DISEASES - University credits: 2
Lessons: 14 hours
Professor: Neri Antonino
General pathology and immunology
Lessons: 7 hours
Medical Oncology
MED/06 - MEDICAL ONCOLOGY - University credits: 2
Lessons: 14 hours
Medical statistics
MED/01 - MEDICAL STATISTICS - University credits: 1
Lessons: 7 hours
by appointment via email
Fondazione IRCCS Istituto Nazionale Tumori, Milan