Human biochemistry
A.A. 2018/2019
Obiettivi formativi
This course is designed to provide the fundamental knowledge to understand the concepts of biochemistry processes that control the functioning and homeostasis of cells and body in physiological and pathophysiological conditions.
Risultati apprendimento attesi
By the end of this course students should be familiar with:
The role of ABC transporters in cell physiology, ABC-related inherited diseases and drug resistance
The role of membrane lipids in cell biology
Physiological aspects of biochemistry, with emphasis on mammalian metabolism, specialized cells and tissues, detoxification mechanisms, energetics, and physiological interrelationships
Biochemical causes of the diseases discussed during the course, as well as current and future opportunities for biochemical-based treatments
The role of ABC transporters in cell physiology, ABC-related inherited diseases and drug resistance
The role of membrane lipids in cell biology
Physiological aspects of biochemistry, with emphasis on mammalian metabolism, specialized cells and tissues, detoxification mechanisms, energetics, and physiological interrelationships
Biochemical causes of the diseases discussed during the course, as well as current and future opportunities for biochemical-based treatments
Periodo: Secondo trimestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Secondo trimestre
Programma
ABC TRANSPORTERS
Structure
Mechanism of action
Role in cell physiology
Role in drug resistance
MEMBRANE LIPIDS: ARCHITECTURE, DYNAMICS AND BIOLOGICAL FUNCTIONS
In/out asymmetry and lateral asymmetry in pathophysiological processes
Aminophospholipids in membrane fusion, cytokinesis clotting, phagocytosis and apoptosis Phosphosinositides: compartimentalization, vesicular traffic and cell signaling
(Glyco)sphingolipids: Lipid Microdomains, signaling platforms, cell-cell communication
Lipids and cell signaling
Lipid mediators in the control of cell proliferation, death and migration: Ceramide , Sphingosine-1-phosphate and Diacylglicerol
"Omics" in lipid signaling
HUMAN BIOCHEMISTRY
Tissue-specific metabolic processes:
Lipoproteins, structure, metabolism, and their role in the regulation of lipid homeostasis. Structural and metabolic alterations of lipoproteins and atherosclerosis.
Liver,
adipose tissue
muscle
metabolic adaptation in physiological conditions (metabolic diseases, aging....)
Biochemistry of the nervous system:
Metabolism and functions: neurons-glia interactions.
Specialized functions of cells of the nervous system
Cell models for the study of biochemical processes in cells of the nervous system
Biochemistry of cancer:
Metabolic processes in the tumor cells
Aberrant glycosylation in the tumor
Cell models
Laboratory sections:
Characterization of lipid composition in cell extracts
Structure
Mechanism of action
Role in cell physiology
Role in drug resistance
MEMBRANE LIPIDS: ARCHITECTURE, DYNAMICS AND BIOLOGICAL FUNCTIONS
In/out asymmetry and lateral asymmetry in pathophysiological processes
Aminophospholipids in membrane fusion, cytokinesis clotting, phagocytosis and apoptosis Phosphosinositides: compartimentalization, vesicular traffic and cell signaling
(Glyco)sphingolipids: Lipid Microdomains, signaling platforms, cell-cell communication
Lipids and cell signaling
Lipid mediators in the control of cell proliferation, death and migration: Ceramide , Sphingosine-1-phosphate and Diacylglicerol
"Omics" in lipid signaling
HUMAN BIOCHEMISTRY
Tissue-specific metabolic processes:
Lipoproteins, structure, metabolism, and their role in the regulation of lipid homeostasis. Structural and metabolic alterations of lipoproteins and atherosclerosis.
Liver,
adipose tissue
muscle
metabolic adaptation in physiological conditions (metabolic diseases, aging....)
Biochemistry of the nervous system:
Metabolism and functions: neurons-glia interactions.
Specialized functions of cells of the nervous system
Cell models for the study of biochemical processes in cells of the nervous system
Biochemistry of cancer:
Metabolic processes in the tumor cells
Aberrant glycosylation in the tumor
Cell models
Laboratory sections:
Characterization of lipid composition in cell extracts
Prerequisiti
The examination consists of a conversation at the end of the course
Materiale di riferimento
During the course we will be provided by the teachers bibliographic references on the topics presented.
BIO/10 - BIOCHIMICA - CFU: 9
Esercitazioni: 24 ore
Lezioni: 52.5 ore
Lezioni: 52.5 ore
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