Mechanisms of diseases
A.A. 2018/2019
Obiettivi formativi
Non definiti
Risultati apprendimento attesi
Non definiti
Periodo: annuale
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Prerequisiti
The course is mainly based on lectures and seminars and includes the following tutorial activities:
· PBL sessions:
· Lab practicals:
o Microbiology.
o Medical genetics.
o Journal club session
The exam will be based on two written parts and three oral parts:
· The WRITTEN TEST 1 will be based on 30 multiple choice questions of general pathology, immunology and microbiology;
· The WRITTEN TEST 2 is composed of 12 multiple choice questions of genetics (6 questions), biochemistry (3 questions) and methodology (3 questions); this test will result in a mark from 18 to 30
· The ORAL EXAMINATION 1 will evaluate general pathology and will result in a marks from 18 to 30.
· The ORAL EXAMINATION 2 will evaluate immunology and will result in a mark from 18 to 30.
· The ORAL EXAMINATION 3 will evaluate microbiology and will result in a mark from 18 to 30.
The written test 1 has a threshold of 23/30 and will not contribute to the final mark.
The written test 2 and all oral examinations tests will contribute to the final mark according to the following algorithm based on the proportion of the CFUs dedicated to each subject:
Written test 2 (genetics/biochemistry/methodology; 4 CFU): mark x/30 x 0.15
Oral examination 1 (general pathology; 7 CFU): mark x/30 x 0.3
Oral examination 2 (immunology; 7 CFU): mark x/30 x 0.3
Oral examination 3 (microbiology; 6 CFU): mark x/30 x 0.25
Written tests can be taken independently from each other.
Only students who have passed both written tests are allowed to take the oral examinations.
The written exams and the oral examinations can be sustained in different dates.
The oral examination sessions 1&2 have to be taken in a single session, the oral examination session 3 can be taken independently from 1&2.
Marks obtained in the different sessions will be considered valid indefinitely.
· PBL sessions:
· Lab practicals:
o Microbiology.
o Medical genetics.
o Journal club session
The exam will be based on two written parts and three oral parts:
· The WRITTEN TEST 1 will be based on 30 multiple choice questions of general pathology, immunology and microbiology;
· The WRITTEN TEST 2 is composed of 12 multiple choice questions of genetics (6 questions), biochemistry (3 questions) and methodology (3 questions); this test will result in a mark from 18 to 30
· The ORAL EXAMINATION 1 will evaluate general pathology and will result in a marks from 18 to 30.
· The ORAL EXAMINATION 2 will evaluate immunology and will result in a mark from 18 to 30.
· The ORAL EXAMINATION 3 will evaluate microbiology and will result in a mark from 18 to 30.
The written test 1 has a threshold of 23/30 and will not contribute to the final mark.
The written test 2 and all oral examinations tests will contribute to the final mark according to the following algorithm based on the proportion of the CFUs dedicated to each subject:
Written test 2 (genetics/biochemistry/methodology; 4 CFU): mark x/30 x 0.15
Oral examination 1 (general pathology; 7 CFU): mark x/30 x 0.3
Oral examination 2 (immunology; 7 CFU): mark x/30 x 0.3
Oral examination 3 (microbiology; 6 CFU): mark x/30 x 0.25
Written tests can be taken independently from each other.
Only students who have passed both written tests are allowed to take the oral examinations.
The written exams and the oral examinations can be sustained in different dates.
The oral examination sessions 1&2 have to be taken in a single session, the oral examination session 3 can be taken independently from 1&2.
Marks obtained in the different sessions will be considered valid indefinitely.
Biochemistry
Programma
Program of the form:
Vitamins in health and disease I (Riboni)
Vitamins in health and disease II (Riboni)
Immunometabolism 1 (Riboni)
Immunometabolism 2: adaptive immunity (Riboni)
Systemic metabolism and immune response in complex diseases (Riboni)
Metabolic derangements in cancer cells (Riboni)
Metabolic changes in patients with tumors (Riboni)
Vitamins in health and disease I (Riboni)
Vitamins in health and disease II (Riboni)
Immunometabolism 1 (Riboni)
Immunometabolism 2: adaptive immunity (Riboni)
Systemic metabolism and immune response in complex diseases (Riboni)
Metabolic derangements in cancer cells (Riboni)
Metabolic changes in patients with tumors (Riboni)
Materiale di riferimento
Bibliography:
· Lieberman M. and Marks A. "Marks' basic medical biochemistry: a clinical approach" 4th ed. Lippincott Williams & Wilkins.
· Lieberman M. and Marks A. "Marks' basic medical biochemistry: a clinical approach" 4th ed. Lippincott Williams & Wilkins.
Genetics
Programma
Program of the form:
Principles of molecular diseases (Finelli)
When genotype is not predictive of phenotype (Finelli)
From Mendelian to complex diseases (Finelli)
Mosaicism (Finelli)
The genetic basis of cancer (Finelli)
Sporadic, familiar and hereditary cancer (Finelli)
Principles of molecular diseases (Finelli)
When genotype is not predictive of phenotype (Finelli)
From Mendelian to complex diseases (Finelli)
Mosaicism (Finelli)
The genetic basis of cancer (Finelli)
Sporadic, familiar and hereditary cancer (Finelli)
Materiale di riferimento
Bibliography:
· Thompson & Thompson Genetics in Medicine" 8th ed., Elsevier, 2015
· Thompson & Thompson Genetics in Medicine" 8th ed., Elsevier, 2015
General pathology and immunology
Programma
Program of the form:
Mechanisms of cellular adaptation, injury and death (Della Bella)
Oxidative stress in human health and diseases (Della Bella)
Intra- and extracellular accumulations leading to human diseases (Della Bella)
The stem cell (Della Bella)
Cellular senescence and aging (Della Bella)
Antigen presenting cells (Della Bella)
Immune responses to viruses (Della Bella)
Immune responses to intracellular bacteria (Della Bella)
Immune responses to extracellular bacteria and fungi (Della Bella)
Mucosal immunity (Della Bella)
Hypersensitivity reactions - part I (Della Bella)
Hypersensitivity reactions - part II (Della Bella)
Autoimmunity (Della Bella)
Primary immunodeficiencies (Della Bella)
Transplantation immunology (Della Bella)
Immunosenescence (Della Bella)
Systemic metabolism and immune response in complex diseases (Della Bella)
Introduction to tumors (Della Bella)
Distinctive features of benign, precancerous and malignant growth (Della Bella)
Molecular basis of cancer (Della Bella)
Carcinogenesis: physical and chemical agents (Della Bella)
Carcinogenesis: infectious agents (Della Bella)
Immune responses to tumors (Della Bella)
Inflammation and cancer (Della Bella)
Angiogenesis (Della Bella)
Tumor angiogenesis (Della Bella)
Metabolic changes in patients with tumors (Della Bella)
Origin of innate immune cells: hematopoiesis (Marchesi)
The acute inflammatory response (Marchesi)
Cell mediators of acute inflammation (Marchesi)
Soluble mediators of acute inflammation (Marchesi)
Leukocyte recruitment (Marchesi)
Pathogen recognition in innate immunity I (Marchesi)
Pathogen recognition in innate immunity II (Marchesi)
The complement system (Marchesi)
Pathogen killing (Marchesi)
Resolution of the inflammatory response (Marchesi)
Tissue repair and fibrosis (Marchesi)
Chronic inflammation (Marchesi)
Acute phase reaction and systemic inflammation (Marchesi)
Hemostasis and coagulation (Marchesi)
Atherosclerosis (Marchesi)
Thrombotic diseases (Marchesi)
Shock (Marchesi)
Bleeding disorders (Marchesi)
Anemias (Marchesi)
T cells development (Locati)
Tolerance (Locati)
T cells functions (Locati)
B cells development (Locati)
Antibodies (Locati)
Immune response polarization (Locati)
Immune circuits in chronic inflammation (Locati)
Negative regulators of the immune response (Locati)
Immune response memory (Locati)
Acquired immunodeficiencies (Mavilio)
From somatic cells to stem cells (Mavilio)
Viral vectors in the therapies of immunologic diseases (Mavilio)
From genetics to immunology: the auto-inflammatory diseases case (Mavilio)
The genetic in the discovery of new diseases (Mavilio)
Flow cytometry applications in immunopathology (Mavilio).
Mechanisms of cellular adaptation, injury and death (Della Bella)
Oxidative stress in human health and diseases (Della Bella)
Intra- and extracellular accumulations leading to human diseases (Della Bella)
The stem cell (Della Bella)
Cellular senescence and aging (Della Bella)
Antigen presenting cells (Della Bella)
Immune responses to viruses (Della Bella)
Immune responses to intracellular bacteria (Della Bella)
Immune responses to extracellular bacteria and fungi (Della Bella)
Mucosal immunity (Della Bella)
Hypersensitivity reactions - part I (Della Bella)
Hypersensitivity reactions - part II (Della Bella)
Autoimmunity (Della Bella)
Primary immunodeficiencies (Della Bella)
Transplantation immunology (Della Bella)
Immunosenescence (Della Bella)
Systemic metabolism and immune response in complex diseases (Della Bella)
Introduction to tumors (Della Bella)
Distinctive features of benign, precancerous and malignant growth (Della Bella)
Molecular basis of cancer (Della Bella)
Carcinogenesis: physical and chemical agents (Della Bella)
Carcinogenesis: infectious agents (Della Bella)
Immune responses to tumors (Della Bella)
Inflammation and cancer (Della Bella)
Angiogenesis (Della Bella)
Tumor angiogenesis (Della Bella)
Metabolic changes in patients with tumors (Della Bella)
Origin of innate immune cells: hematopoiesis (Marchesi)
The acute inflammatory response (Marchesi)
Cell mediators of acute inflammation (Marchesi)
Soluble mediators of acute inflammation (Marchesi)
Leukocyte recruitment (Marchesi)
Pathogen recognition in innate immunity I (Marchesi)
Pathogen recognition in innate immunity II (Marchesi)
The complement system (Marchesi)
Pathogen killing (Marchesi)
Resolution of the inflammatory response (Marchesi)
Tissue repair and fibrosis (Marchesi)
Chronic inflammation (Marchesi)
Acute phase reaction and systemic inflammation (Marchesi)
Hemostasis and coagulation (Marchesi)
Atherosclerosis (Marchesi)
Thrombotic diseases (Marchesi)
Shock (Marchesi)
Bleeding disorders (Marchesi)
Anemias (Marchesi)
T cells development (Locati)
Tolerance (Locati)
T cells functions (Locati)
B cells development (Locati)
Antibodies (Locati)
Immune response polarization (Locati)
Immune circuits in chronic inflammation (Locati)
Negative regulators of the immune response (Locati)
Immune response memory (Locati)
Acquired immunodeficiencies (Mavilio)
From somatic cells to stem cells (Mavilio)
Viral vectors in the therapies of immunologic diseases (Mavilio)
From genetics to immunology: the auto-inflammatory diseases case (Mavilio)
The genetic in the discovery of new diseases (Mavilio)
Flow cytometry applications in immunopathology (Mavilio).
Materiale di riferimento
Bibliography:
PATHOLOGY
· AK Abbas, AH Lichtman, S Pillai. CELLULAR AND MOLECULAR IMMUNOLOGY. 8th ed. Elsevier 2015
IMMUNOLOGY
· V Kumar, AK Abbas, JC Aster. ROBBINS AND COTRAN, PATHOLOGIC BASIS OF DISEASES. 9th ed. Elsevier 2015
PATHOLOGY
· AK Abbas, AH Lichtman, S Pillai. CELLULAR AND MOLECULAR IMMUNOLOGY. 8th ed. Elsevier 2015
IMMUNOLOGY
· V Kumar, AK Abbas, JC Aster. ROBBINS AND COTRAN, PATHOLOGIC BASIS OF DISEASES. 9th ed. Elsevier 2015
Microbiology
Programma
Program of the form:
The good and bad of microorganisms (Borghi)
Prokaryotic cell structure and function (Borghi)
Microbial pathogenesis (Borghi)
Fungal structure, function, and pathogenesis (Borghi)
Basic concepts of parassitology (Ferrante)
Parasites of medical relevance (Ferrante)
RNA positive viruses II (Ferrante)
RNA negative viruses I (Ferrante)
Viral hepatitis II: Hepatitis C virus, Hepatitis E virus, Hepatitis G virus (Ferrante)
DNA viruses: polyomaviridae (Ferrante)
Delta retroviruses, retroids, prions (Ferrante)
Endogenous Retroviruses (Ferrante)
Viruses: structure, genetics and evolution (Delbue)
Viruses: classification and replication properties (Delbue)
Viruses: pathogenesis of viral infections (Delbue)
RNA positive viruses I: picornaviridae (Delbue)
RNA negative viruses II (Delbue)
DNA viruses: herpesviridae (Delbue)
Parvoviridae, adenoviridae, papillomaviridae (Delbue)
Retroviridae: human immunodeficiency viruses (Delbue)
Acquired immunodeficiencies (Delbue)
Toxigenic bacteria (Borghi)
Pyogenic bacteria (Borghi)
Spore-forming bacteria (Borghi)
Intracellular bacteria (Borghi)
Granulomatous infections (Borghi)
Bacteria infecting the gut (Borghi)
Microorganisms infecting the central nervous system (Borghi)
Nosocomial pathogens (Borghi)
Microorganisms involved in diseases other than infections (Borghi)
The good and bad of microorganisms (Borghi)
Prokaryotic cell structure and function (Borghi)
Microbial pathogenesis (Borghi)
Fungal structure, function, and pathogenesis (Borghi)
Basic concepts of parassitology (Ferrante)
Parasites of medical relevance (Ferrante)
RNA positive viruses II (Ferrante)
RNA negative viruses I (Ferrante)
Viral hepatitis II: Hepatitis C virus, Hepatitis E virus, Hepatitis G virus (Ferrante)
DNA viruses: polyomaviridae (Ferrante)
Delta retroviruses, retroids, prions (Ferrante)
Endogenous Retroviruses (Ferrante)
Viruses: structure, genetics and evolution (Delbue)
Viruses: classification and replication properties (Delbue)
Viruses: pathogenesis of viral infections (Delbue)
RNA positive viruses I: picornaviridae (Delbue)
RNA negative viruses II (Delbue)
DNA viruses: herpesviridae (Delbue)
Parvoviridae, adenoviridae, papillomaviridae (Delbue)
Retroviridae: human immunodeficiency viruses (Delbue)
Acquired immunodeficiencies (Delbue)
Toxigenic bacteria (Borghi)
Pyogenic bacteria (Borghi)
Spore-forming bacteria (Borghi)
Intracellular bacteria (Borghi)
Granulomatous infections (Borghi)
Bacteria infecting the gut (Borghi)
Microorganisms infecting the central nervous system (Borghi)
Nosocomial pathogens (Borghi)
Microorganisms involved in diseases other than infections (Borghi)
Materiale di riferimento
Bibliography:
MICROBIOLOGY
· P Murray, K Rosenthal, M Pfaller. MEDICAL MICROBIOLOGY. 8th ed. Elsevier 2016
MICROBIOLOGY
· P Murray, K Rosenthal, M Pfaller. MEDICAL MICROBIOLOGY. 8th ed. Elsevier 2016
Moduli o unità didattiche
Biochemistry
BIO/10 - BIOCHIMICA - CFU: 1
Lezioni: 12 ore
Docente:
Riboni Laura Piera Carla Giulia
General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 15
Esercitazioni: 32 ore
Lezioni: 132 ore
Problem Based Learning: 24 ore
Lezioni: 132 ore
Problem Based Learning: 24 ore
Genetics
MED/03 - GENETICA MEDICA - CFU: 2
Esercitazioni: 16 ore
Lezioni: 12 ore
Lezioni: 12 ore
Docenti:
Crippa Milena, Finelli Palma
Microbiology
MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA - CFU: 6
Lezioni: 72 ore
Docente/i
Ricevimento:
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Polo universitario San Paolo, blocco C, ottavo piano, stanza 813
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LITA di Segrate; Humanitas - building 8
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Ist Auxologico Italiano, Via Zucchi 18 - 20095 Cusano Milanino
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Laboratori area Pieve c/o Istituto Clinico Humanitas
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Istituto Clinico Humanitas, Via Alessandro Manzoni 113, Rozzano, Milano