Molecular and immunological interactions in parasitology
A.A. 2019/2020
Obiettivi formativi
The aim of the course is to provide students with theoretical and practical information on molecular, biochemical and immunological dynamics established in the host-parasite coevolution process. The students will be introduced to the comprehension of the basic biological mechanisms determining the within-host (immunological) and between-host (epidemiological) relationships with parasites, and the parasite-disease dynamics.
Risultati apprendimento attesi
The student will acquire knowledge and understanding of the principles and mechanisms underlying the evolutionary associations between hosts and parasites. Ability to apply knowledge and understanding will concern acquisition of specific techniques related to host-parasite researches,gain of terminology linked to host-parasite relationship and improvement of scientific communication skills
Periodo: Secondo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Secondo semestre
Prerequisiti
Knowledge required for the access to the Degree Course, basic principles and theory of mass spectrometry-based proteomics.
Modalità di verifica dell’apprendimento e criteri di valutazione
The learning assessment will be carried out through a written test in English including both multiple-choice questions and open questions.
Module: Molecular patterns in host-parasite co-evolution
Programma
1. Ecological, epidemiological and physiopathological parameters of host-parasite interaction (6 hrs)
2. Molecular and genetic determinants of host-parasite co-evolution (6 hrs)
3. Molecular mechanisms of parasite diversification in response to environmental and host variations (6 hrs)
2. Molecular and genetic determinants of host-parasite co-evolution (6 hrs)
3. Molecular mechanisms of parasite diversification in response to environmental and host variations (6 hrs)
Metodi didattici
Lectures, group work.
Materiale di riferimento
Materials will be provided during the course and uploaded to the corresponding website of the Ariel platform.
Module: Immunological interactions and applied immunology in parasitology
Programma
1) An overview on the molecular and immunological dynamics that the host develops in relationship with parasites and its endosymbionts; (6 hours)
2) Examples of relationships between the host. the parasite and its endosymbionts (some examples: Dirofilaria immitis-Wolbachia-vertebrate hosts; Ixodes ricinus-Midichloria mitochondrii (or vector borne pathogens)-vertebrate host) (8 hours)
3) Practical abilities to immunological test (ELISA and Western blot) and gene expression analyses (4 hours)
2) Examples of relationships between the host. the parasite and its endosymbionts (some examples: Dirofilaria immitis-Wolbachia-vertebrate hosts; Ixodes ricinus-Midichloria mitochondrii (or vector borne pathogens)-vertebrate host) (8 hours)
3) Practical abilities to immunological test (ELISA and Western blot) and gene expression analyses (4 hours)
Metodi didattici
Lectures, practical laboratory activities, group work.
Materiale di riferimento
Material provided by the teacher and uploaded to the Ariel platform.
Module: Biochemical bases in host-parasite interactions
Programma
1. High-throughput proteomic and phosphoproteomic approaches for the analysis of host-parasite interactions (4 hours)
2. Computer based functional analysis of complex proteomic large datasets (4 hours)
3. Biochemical approaches to the quantitative characterization of protein/protein, protein/nucleic acid and protein/small ligand (/drug) interactions (4 hours)
2. Computer based functional analysis of complex proteomic large datasets (4 hours)
3. Biochemical approaches to the quantitative characterization of protein/protein, protein/nucleic acid and protein/small ligand (/drug) interactions (4 hours)
Metodi didattici
Lectures, computer aided group work
Materiale di riferimento
Materials will be provided during the course and uploaded to the corresponding website of the Ariel platform.
Moduli o unità didattiche
Module: Biochemical bases in host-parasite interactions
BIO/10 - BIOCHIMICA - CFU: 2
Lezioni: 12 ore
Module: Immunological interactions and applied immunology in parasitology
VET/06 - PARASSITOLOGIA E MALATTIE PARASSITARIE DEGLI ANIMALI - CFU: 3
Lezioni: 18 ore
Module: Molecular patterns in host-parasite co-evolution
VET/06 - PARASSITOLOGIA E MALATTIE PARASSITARIE DEGLI ANIMALI - CFU: 3
Lezioni: 18 ore