Molecular and Immunological Interactions in Parasitology
A.Y. 2019/2020
Learning objectives
The aim of the course is to provide students with theoretical and practical information on molecular, biochemical and immunological dynamics established in the host-parasite coevolution process. The students will be introduced to the comprehension of the basic biological mechanisms determining the within-host (immunological) and between-host (epidemiological) relationships with parasites, and the parasite-disease dynamics.
Expected learning outcomes
The student will acquire knowledge and understanding of the principles and mechanisms underlying the evolutionary associations between hosts and parasites. Ability to apply knowledge and understanding will concern acquisition of specific techniques related to host-parasite researches,gain of terminology linked to host-parasite relationship and improvement of scientific communication skills
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
Second semester
Prerequisites for admission
Knowledge required for the access to the Degree Course, basic principles and theory of mass spectrometry-based proteomics.
Assessment methods and Criteria
The learning assessment will be carried out through a written test in English including both multiple-choice questions and open questions.
Module: Molecular patterns in host-parasite co-evolution
Course syllabus
1. Ecological, epidemiological and physiopathological parameters of host-parasite interaction (6 hrs)
2. Molecular and genetic determinants of host-parasite co-evolution (6 hrs)
3. Molecular mechanisms of parasite diversification in response to environmental and host variations (6 hrs)
2. Molecular and genetic determinants of host-parasite co-evolution (6 hrs)
3. Molecular mechanisms of parasite diversification in response to environmental and host variations (6 hrs)
Teaching methods
Lectures, group work.
Teaching Resources
Materials will be provided during the course and uploaded to the corresponding website of the Ariel platform.
Module: Immunological interactions and applied immunology in parasitology
Course syllabus
1) An overview on the molecular and immunological dynamics that the host develops in relationship with parasites and its endosymbionts; (6 hours)
2) Examples of relationships between the host. the parasite and its endosymbionts (some examples: Dirofilaria immitis-Wolbachia-vertebrate hosts; Ixodes ricinus-Midichloria mitochondrii (or vector borne pathogens)-vertebrate host) (8 hours)
3) Practical abilities to immunological test (ELISA and Western blot) and gene expression analyses (4 hours)
2) Examples of relationships between the host. the parasite and its endosymbionts (some examples: Dirofilaria immitis-Wolbachia-vertebrate hosts; Ixodes ricinus-Midichloria mitochondrii (or vector borne pathogens)-vertebrate host) (8 hours)
3) Practical abilities to immunological test (ELISA and Western blot) and gene expression analyses (4 hours)
Teaching methods
Lectures, practical laboratory activities, group work.
Teaching Resources
Material provided by the teacher and uploaded to the Ariel platform.
Module: Biochemical bases in host-parasite interactions
Course syllabus
1. High-throughput proteomic and phosphoproteomic approaches for the analysis of host-parasite interactions (4 hours)
2. Computer based functional analysis of complex proteomic large datasets (4 hours)
3. Biochemical approaches to the quantitative characterization of protein/protein, protein/nucleic acid and protein/small ligand (/drug) interactions (4 hours)
2. Computer based functional analysis of complex proteomic large datasets (4 hours)
3. Biochemical approaches to the quantitative characterization of protein/protein, protein/nucleic acid and protein/small ligand (/drug) interactions (4 hours)
Teaching methods
Lectures, computer aided group work
Teaching Resources
Materials will be provided during the course and uploaded to the corresponding website of the Ariel platform.
Module: Biochemical bases in host-parasite interactions
BIO/10 - BIOCHEMISTRY - University credits: 2
Lessons: 12 hours
Module: Immunological interactions and applied immunology in parasitology
VET/06 - PARASITOLOGY AND ANIMAL PARASITIC DISEASES - University credits: 3
Lessons: 18 hours
Module: Molecular patterns in host-parasite co-evolution
VET/06 - PARASITOLOGY AND ANIMAL PARASITIC DISEASES - University credits: 3
Lessons: 18 hours