Vaccinology

A.A. 2019/2020
8
Crediti massimi
48
Ore totali
SSD
AGR/18 VET/05
Lingua
Inglese
Obiettivi formativi
The course aims to provide a comprehensive and integrated overview in the important field of vaccinology, from immunology to all types of vaccine development, production, delivery and effect evaluation, including also the approaches for plant transformation (GMO and production of heterologous proteins)
Risultati apprendimento attesi
The student is expected to reach the following results:
Theoretical learning
Gain knowledge on:
- Different types of veterinary vaccines and routes of vaccination
- Methodologies to prepare each type of vaccine, including oral vaccines
- Effects of vaccines in inducing specific and protective immune response
- Genetic modification of crops and medical molecular farming
- Key risk assessment and advantages of edible vaccines in veterinary medicine
Practical learning
- Know how to plan and prepare at least for phase 1 (in laboratory) a vaccine
- Know routes and time to perform vaccination
- Evaluation of genetically modified plants
- Ability to assess the effect of vaccination
Programma e organizzazione didattica

Edizione unica

Responsabile
Periodo
Secondo semestre
Prerequisiti
Not required any preliminary knowledge
Modalità di verifica dell’apprendimento e criteri di valutazione
The obtainment of the expected learning outcomes by the student are assessed by an oral examination based on questions with open answer and questions with closed answer, which include also the description of the practical activity.
The evaluation parameters include correctness of answer, comprehension of the topics of the program, ability to connect them and propriety of language.
The grade is expressed in thirtieths and it is communicated to the student immediately after the end of the oral exam.
Module: Innovative vaccine development and production
Programma
Ricombinant vaccines development strategies
Subunit vaccines and Adjuvants (including liposomes, ISCOMs and VLPs)
Live attenuated recombinant vaccines
Genetic vaccines (DNA and RNA)
Innovative approaches (CpG motifs, peptide vaccines and others)
Metodi didattici
The teaching consists in theoretical classes and practical classes
Materiale di riferimento
Handouts will be provided by the teacher through ARIEL website
Module: Practical aspects of vaccinology
Programma
History, passive & active immunization.
Veterinary vaccine development: from idea to delivery; market, registration and pharmacovigilance
Types of veterinary vaccines: from traditional to modern drugs
Field application of human and veterinary vaccines, herd immunity
Vaccine side effects: truth & hoax
Metodi didattici
The teaching consists in theoretical classes and practical classes
Materiale di riferimento
Handouts will be provided by the teacher through ARIEL website
Module: Plant-based production of oral vaccines
Programma
Plant transformation tools: Agrobacterium-mediated (stable and transient) and biolistic approach
Biomass Production and evaluation of heterologous antigenic protein expression: the example of tobacco plants
An example of application: pigs fed a tobacco seed based oral vaccines
Metodi didattici
The teaching consists in theoretical classes and practical classes
Materiale di riferimento
Handouts will be provided by the teacher through ARIEL website
Moduli o unità didattiche
Module: Innovative vaccine development and production
VET/05 - MALATTIE INFETTIVE DEGLI ANIMALI DOMESTICI - CFU: 3
Lezioni: 18 ore
Docente: Turin Lauretta

Module: Plant-based production of oral vaccines
AGR/18 - NUTRIZIONE E ALIMENTAZIONE ANIMALE - CFU: 2
Lezioni: 12 ore
Docente: Rossi Luciana

Module: Practical aspects of vaccinology
VET/05 - MALATTIE INFETTIVE DEGLI ANIMALI DOMESTICI - CFU: 3
Lezioni: 18 ore

Siti didattici
Docente/i
Ricevimento:
sempre su appuntamento
Via Dell'Università 6, Lodi; Via Trentacoste 2 - Milano
Ricevimento:
Lunedi pomeriggio ore 14-18
Studio - Sezione di Microbiologia e Immunologia Veterinaria - Via Celoria 10 - Milano