Mechanism of action
Role in cell physiology
Role in drug resistance
MEMBRANE LIPIDS: ARCHITECTURE, DYNAMICS AND BIOLOGICAL FUNCTIONS
In/out asymmetry and lateral asymmetry in pathophysiological processes
Aminophospholipids in membrane fusion, cytokinesis clotting, phagocytosis and apoptosis Phosphosinositides: compartimentalization, vesicular traffic and cell signaling
(Glyco)sphingolipids: Lipid Microdomains, signaling platforms, cell-cell communication
Lipids and cell signaling
Lipid mediators in the control of cell proliferation, death and migration: Ceramide , Sphingosine-1-phosphate and Diacylglicerol
"Omics" in lipid signaling
Tissue-specific metabolic processes:
Lipoproteins, structure, metabolism, and their role in the regulation of lipid homeostasis. Structural and metabolic alterations of lipoproteins and atherosclerosis.
metabolic adaptation in physiological conditions (metabolic diseases, aging....)
Biochemistry of the nervous system:
Metabolism and functions: neurons-glia interactions.
Specialized functions of cells of the nervous system
Cell models for the study of biochemical processes in cells of the nervous system
Biochemistry of cancer:
Metabolic processes in the tumor cells
Aberrant glycosylation in the tumor
Characterization of lipid composition in cell extracts
Being an exam of the second trimester of the first year, there are no specific prerequisites other than those required for access to the degree course
Teachers will mainly give frontal lectures. During the course, group works will be carried out on specific subjects of the programme. For this activity the students will be organized in small groups to develop the topic and lead the class discussion on the subject. The course also includes single workstation laboratory activities focused on lipid biochemistry.
Modalità di verifica dell’apprendimento e criteri di valutazione
The assessment of whether the expected learning outcomes have been achieved is based on an oral exam organised in interviews with the different teachers on the topics they are dealing with. The exam, in addition to the assessment of knowledge, is aimed at ascertaining the ability to organize and integrate the knowledge acquired, the exposition skills and the proper use of specialist language.
Marks are expressed in thirtieths and will be composed of the weighted average of the marks obtained in the different interviews.
An intermediate (optional) open-answer test on cell biochemistry topics is planned. The mark of the intermediate test contributes to the final grade instead of the interview on cell biochemistry. The results of the intermediate test are communicated anonymously through the Ariel platform.