Radiomics

1. Radiobiology
Interactions of ionising radiation with matter
Radiation effects on healthy and tumor tissue
Radiosensitivity and radioresistance of tissue

2. Imaging acquisition techniques:
Digital diagnostic images: matrix, spatial resolution, contrast resolution, archive and distribution. Processing of digital images.
Mechanical waves and ultrasound image formation. Doppler phenomenon. Ultrasound contrast media and harmonic imaging.
Computerized tomography: technological evolution of the equipment, reconstruction through sinograms and back projection.
Hounsfield unit and window concept.
Magnetic Resonance: signal genesis, relaxation time T1 and T2, spatial encoding.
Contrast agents in radiology and MRI

3. Oncological radiotherapy
Indications to radiotherapy in the most common solid tumors and hematological malignancies
Radiotherapy devices and modalities
Work flow in radiotherapy
Image guided radiotherapy
Tumor remission and normal tissue toxicity

4. Images are numbers:
Radiomic goals
Radiologic images are biomarkers for oncologic response evaluation and for response prediction
Radiomic pathways:
Target lesions identification
Target lesions contouring
Extraction of target lesions
Radiomic analysis
Radiomic features description
Radiomic features variability and causes of variability

5. Radiomics and radiogenomics
Clinical applications
Treatment personalisation
Methodological challenges