Cellular regeneration techniques

A.Y. 2018/2019
7
Max ECTS
48
Overall hours
SSD
VET/01
Language
Italian
Learning objectives
The course will provide the students with a detailed knowledge of the molecular and cellular principles that regulate embryonic development. This knowledge will be extended to the biology of stem cells both tissue specific and embryonic. The course will include some information on the most recent technologies of cell conversion. Finally, the possible therapeutic application of these cells will be critically assessed.
Expected learning outcomes
Undefined
Course syllabus and organization

Single session

Responsible
Lesson period
First semester
ATTENDING STUDENTS
Unita' didattica: Medicina rigenerativa: principi biologici e procedure di laboratorio
Course syllabus
Stem cells: biological principles
Embryonic stem cells (ESC): origins and biological characteristics
The molecular mechanisms that regulate pluripotency of ESC
The ESC in species other than mice
Cellular reprogramming
iPS cells
Cell conversion
Mesenchymal stem cells
Muscular stem cells
Unita' didattica: Embriologia molecolare, dalla cellula all'apparato
Course syllabus
Key molecules in early embryo development
Trofectoderm and inner cell mass. Transcription factors controlling cell plasticity
Imprinting and epigenetic regulation
Maternal and paternal contribution to the mitotic spindle, centromere and centrioles
Cytoplasm compartimentalization
Telomerase and cell death
Epigenetics and cell fate definition
Developmental cues, gradients, morphogenesis
Genome editing (siRNA, ZFN, Talens, Crispr/Cas)
NON-ATTENDING STUDENTS
Unita' didattica: Medicina rigenerativa: principi biologici e procedure di laboratorio
Course syllabus
Stem cells: biological principles
Embryonic stem cells (ESC): origins and biological characteristics
The molecular mechanisms that regulate pluripotency of ESC
The ESC in species other than mice
Cellular reprogramming
iPS cells
Cell conversion
Mesenchymal stem cells
Muscular stem cells
Unita' didattica: Embriologia molecolare, dalla cellula all'apparato
Course syllabus
Key molecules in early embryo development
Trofectoderm and inner cell mass. Transcription factors controlling cell plasticity
Imprinting and epigenetic regulation
Maternal and paternal contribution to the mitotic spindle, centromere and centrioles
Cytoplasm compartimentalization
Telomerase and cell death
Epigenetics and cell fate definition
Developmental cues, gradients, morphogenesis
Genome editing (siRNA, ZFN, Talens, Crispr/Cas)
Unita' didattica: Embriologia molecolare, dalla cellula all'apparato
VET/01 - VETERINARY ANATOMY - University credits: 3
Practicals: 12 hours
Lessons: 12 hours
Professor: Brevini Tiziana
Unita' didattica: Medicina rigenerativa: principi biologici e procedure di laboratorio
VET/01 - VETERINARY ANATOMY - University credits: 4
Lessons: 24 hours
Professor: Gandolfi Fulvio
Professor(s)
Reception:
From Monday to Friday upon appointment
Office or after the lectures