Genetics

A.y. 2018/2019
8
Max ECTS
76
Overall hours
SSD
AGR/07 BIO/18
Language
Italian
Learning objectives
Objective of the course is to provide students with the fundamental knowledge of genetics. The topics will include traits transmissibility, genetic linkage, mutations, gene expression and regulation.
Expected learning outcomes
Undefined
Course syllabus and organization

English

Responsible
Lesson period
Second semester
AGR/07 - AGRICULTURAL GENETICS - University credits: 0
BIO/18 - GENETICS - University credits: 0
Practicals: 24 hours
Lessons: 52 hours

Italiano

Responsible
Lesson period
Second semester
Course syllabus
Chromosomal basis of genetics. DNA organization in chromosomes and genes. Cell divisions: Mitosis, meiosis. Meiosis and sexual reproduction in eucariots. DNA replication and synthesis.
Mendelian genetics. The monohybrid and dihybrid cross. Independent assortment and genetic variation. Statistical evaluation of genetic data. Human pedigrees. Multiple alleles. The ABO blood Group. X-linked genes in Drosophila. X-linked inheritance in humans. Sex determination.
Gene linkage and genetic mapping. Incomplete linkage, Crossing over and mapping. Three-point mapping. Interference and coefficient of coincidence. Mapping studies. Mitotic crossing over and mosaics.
Genetic of bacteria. Bacterial mutations and selection. Plasmids and episomes. Genetic recombination in bacteria, conjugation. Bacterial transformation.
The genetic study of bacteriophages. Transduction: virus mediated DNA transfer.
Molecular genetics. Gene structure, expression and function in prokaryotes and eukaryotes. Promoter and coding regions. Transcription and translation. Regulation of transcription. The genetic code and its characteristics. The one-gene: one-enzyme hypotesis. Gene interaction. Complementation.
DNA-mutation. Classification of mutations and frequency. The molecular basis of mutation. Reversion and suppression. Variation in chromosome structure and arrangements: deletion, duplications, inversions, translocations. Variation in chromosome number: aneuploidy and polyploidy.
Molecular mechanisms of gene regulation in prokaryotes. The lactose operon in E.coli, an inducible system, its structure and negative and positive control. Tryptophan metabolism in E.coli: a repressible gene system.
Population genetics. Population, gene pools and allele frequencies. The Hardy-Weinberg law. Factors that alter allele frequencies: genetic drift, selection, mutation and variation.
AGR/07 - AGRICULTURAL GENETICS - University credits: 0
BIO/18 - GENETICS - University credits: 0
Practicals: 24 hours
Lessons: 52 hours
Professor: Consonni Gabriella