Nutrition-related diseases

A.y. 2018/2019
Overall hours
MED/04 MED/13
Learning objectives
To attain a specific knowledge of the role of various factors which can compromise the health and well being of a single cell and, hence, of the whole organism. To know in detail the molecular and cellular processes involved in the major diseases and the possible relation with the diet
Expected learning outcomes
The student should recognize, understand and describe critically the causes, the pathogenic mechanisms and the pathological consequences of the main noxious and damaging agents, including life style and diet
Course syllabus and organization

Single session

Lesson period
Course syllabus
BASIS OF GENERAL PATHOLOGY General aetiology 1. Pathogenetic mechanisms. Interaction between intrinsic causal factors (elements of genetics) and acquired effectors. 2. Cell damage and death; necrosis and apoptosis in physiological and pathological processes: the mechanisms. 3. Oxidative stress and related pathologic conditions (antioxidant defenses, vitamines). Inflammation 1. Inflammatory agents, vascular events, cells of the inflammatory process. 2. Mechanisms of leukocyte recruitment and phagocytosis. 3. Chemical mediators which coordinate the various phases of inflammation. Oncology 1. Distinction between non neoplastic and neoplastic growth. 2. Mutations and cancer. 3. Lack of control of the cell cycle in tumors: role of oncogenes and tumor suppressors. 4. Neoplastic progression, angiogenesis, invasion and metastasis. 5. Aetiology of tumors. PHYSIOPATHOLOGY OF MULTIFACTORIAL DISEASES 1. Blood physiopathology: anemia (erythropoiesis- iron and pholates deficiency). 2. Obesity (control of energy homeostasis and body weight-signals of hunger and satiety). 3. Diabetes (classifications- glycemic control- insulin resistance- metabolic alterations - long term complications ). 4. Steatosis (alcoholic and non alcoholic). 5. Hypertension (regulation of blood pression-consequences). 6. Atherosclerosis (risk factors-pathogenesis-consequences). 7. Tumors [interaction between genetic background and environment (food as environmental factor)-cancerogens in the diet-chemoprevention]. 8. Allergies and intollerances: molecules and cells involved-allergens (nature and identification)-anaphylactic shock. 9. Gout (purine metabolism-pathogenesis of hyperuricemia). 10. Physiopathological aspect of nutrition in pregnancy. GENETICS. Nutrigenetic and nutrigenomic will be also examined, by analysing the role of diet as an environmental mechanism of interaction with the genome and regulator of gene expression
Teaching methods
Textbooks: G.M. Pontieri ¿Patologia Generale e Fisiopatologia Generale per i corsi di laurea in professioni sanitarie.¿ (Piccin Ed.) G Cairo, S Recalcati, L Tacchini "Patologia" (serie Quick Review EdiSES)Other material will be suggested during classes and slides will be available in ARIEL
Lessons: 48 hours
Professor: Cairo Gaetano
Sistematica e prevenzione
MED/13 - ENDOCRINOLOGY AND METABOLISM - University credits: 5
Lessons: 40 hours
Professor: Folli Franco