Pathology
A.Y. 2018/2019
Learning objectives
We will study causes and mechanisms of disease. To this end, we will examine the molecular, cellular and functional effects due to the occurrence of pathogenic events (such as genetic alterations, activation of cellular oncogenes). We will study cell damage, death, adaptation, and the systemic and local reaction to tissue damage, with an in depth analysis of the inflammatory reaction.
Expected learning outcomes
Undefined
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Course syllabus
The cellular damage
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
Teaching methods
Traditional, lectures with power point slides.
Attendance is strongly suggested
Prerequisites and examination procedures
Written (open questions). Students can split the exam in two parts (one part in itinere, the last part at the end of the course).
Language
Italian
Web page
http://users.unimi.it/minucci/didattica.htm
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
Teaching methods
Traditional, lectures with power point slides.
Attendance is strongly suggested
Prerequisites and examination procedures
Written (open questions). Students can split the exam in two parts (one part in itinere, the last part at the end of the course).
Language
Italian
Web page
http://users.unimi.it/minucci/didattica.htm
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 6
Lessons: 48 hours
Professor:
Minucci Saverio
Professor(s)