The aim of the course is to give to the student the knowledge of xenobiotics with toxic activity for the animals, with particular reference to the mechanisms of action. In addition, basic toxicological risk assessment concepts for food of animal origin will be provided.
Expected learning outcomes
At the end of the course the student must be able to describe the toxicological characteristics of the main xenobiotics that can enter the livestock production cycle
Introduction: chapters and purposes of toxicology, history of toxicology, classification and source of poisons (6 h) Toxicocinetics exposure, absorption, distribution, metabolism, excretion (4 h) Toxicodynamics and mechanisms of action of toxic substances (2 h) Exogenous and endogenous factors that affect the toxicity of poisons (2 h) Lethal dose (DL 50) - Maximum Tolerated Dose in large animals (2 h) Experimental models and meaning of "Subacute Toxicity" and "Chronic Toxicity" (2 h) Specific toxicity: mutagenicity, carcinogenicity, teratogenesis, reproduction effects (2 h) Determination of threshold values (DGA, ADI, TDI, TWI etc.) (2 h) Determination of the tolerance level - MRL (2 h) Characterization management and communicationof of the risk (2 h) Pesticides (8 h) Poisoning by metals or minerals (6 h) Poisonings from toxic plants (2 h) Poisoning from mycotoxins (4 h) Poisoning from non-proteic nitrogen compounds (2 h)
Prerequisites for admission
Knowledge of chemistry and biochemistry are required.
The course includes lectures, held in the classroom.
The material used in the classroom for explanations will be present on the UNIMI Ariel portal. Books Mengozzi-Soldani (2010) Tossicologia Veterinaria, Idelson-Gnocchi GUPTA R.C. (2018) Veterinary toxicology 3rd Ed- edited by Elsevier Academic Press.
Assessment methods and Criteria
Verification of learning is carried out through a written examination with open questions concerning special general toxicology.