Chemotherapy and biological drugs

A.Y. 2019/2020
8
Max ECTS
64
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The course program includes the teaching of: 1) biochemical and pharmacological properties, production methods and clinical indications for biotechnological drugs; 2) mechanism of action, pharmacology and clinical toxicology of anti-infective, anti-tumor and immunoregulatory chemotherapeutics. The aim of the course is to provide the knowledge on the rational bases for the development and clinical use of these classes of drugs and to contribute to the formation of professionals with the cultural and practical skills necessary for the future occupational opportunities within the health area.
Expected learning outcomes
Students 1) know the mechanisms by which biotechnological and chemotherapeutic drugs act; 2) know the methodologies for the synthesis of biotechnological drugs; 3) are able to predict the pharmacodynamics and pharmacokinetics of biotechnological and chemotherapeutic drugs; 4) know the classes of drugs available for the different therapeutic areas; 5) are able to predict adverse reactions associated with the use of biotechnological and chemotherapeutic drugs
Course syllabus and organization

Linea AL

Responsible
Lesson period
First semester
Course syllabus
1. CHEMOTHERAPY OF MICROBIAL DISEASES
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza

2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs

3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer

4. IMMUNE MODULATORS
4.1 Immune suppressing agents
3.2 Immune stimulating agents
Prerequisites for admission
"Applied Microbiology and Hygiene" ("Microbiologia applicata ed Igiene") and "Pharmacology and Pharmacotherapy" ("Farmacologia e Farmacoterapia").
Teaching methods
Slides available on the Ariel website
Teaching Resources
FARMACI BIOTECNOLOGICI. Aspetti farmacologici e clinici dei medicinali biotecnologici
Vegeto E, Maggi A, Minghetti P

Ed. CEA-ZANICHELLI


Farmacologia Molecolare e Cellulare

Clementi E, Fumagalli G

Ed. EdiSES


Farmacologia generale e clinica

Katzung & Trevor,

Ed PICCIN


"Le basi farmacologiche della terapia

Goodman & Gillman

Ed. Zanichelli


Le basi biologiche e cliniche delle Malattie Infettive

Shulman et al

Ed. EdiSES
Assessment methods and Criteria
The exam consists of a written part, delivered through tests (30 multiple choice questions) at the university IT offices, and an oral part. Admission to the oral exam is subject to passing the written test (at least 20 correct answers).
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Vegeto Elisabetta

Linea MZ

Responsible
Lesson period
First semester
Course syllabus
1. CHEMOTHERAPY OF MICROBIAL DISEASES
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza

2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs

3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer

4. IMMUNE MODULATORS
4.1 Immune suppressing agents
3.2 Immune stimulating agents
Prerequisites for admission
"Applied Microbiology and Hygiene" ("Microbiologia applicata ed Igiene") and "Pharmacology and Pharmacotherapy" ("Farmacologia e Farmacoterapia").
Teaching methods
Slides available on the Ariel website
Teaching Resources
FARMACI BIOTECNOLOGICI. Aspetti farmacologici e clinici dei medicinali biotecnologici
Vegeto E, Maggi A, Minghetti P

Ed. CEA-ZANICHELLI


Farmacologia Molecolare e Cellulare

Clementi E, Fumagalli G

Ed. EdiSES


Farmacologia generale e clinica

Katzung & Trevor,

Ed PICCIN


"Le basi farmacologiche della terapia

Goodman & Gillman

Ed. Zanichelli


Le basi biologiche e cliniche delle Malattie Infettive

Shulman et al

Ed. EdiSES
Assessment methods and Criteria
The exam consists of a written part, delivered through tests (30 multiple choice questions) at the university IT offices, and an oral part. Admission to the oral exam is subject to passing the written test (at least 20 correct answers).
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor: Vegeto Elisabetta
Professor(s)