Immunology and Immunopathology

A.Y. 2019/2020
5
Max ECTS
64
Overall hours
SSD
MED/04
Language
Italian
Learning objectives
The course of Immunology and Immunopathology aims to provide fundamental knowledge about the components of the immune system, their functioning, the defense mechanisms against different pathogens (viruses, bacteria, and parasites), the pathogenesis of immune diseases (hypersensitivity, autoimmunity, immunodeficiencies), and on the mechanisms underlying the rejection of transplants and the anti-tumor immune response. It also provides knowledge of the main immunological techniques used in research and diagnostics.
Expected learning outcomes
At the end of the course the student will be able:
· to know and describe the organization and functioning of the immune system, its cells and its molecules,
· to know the fundamental stages of the immune system and its changes over the course of life (intrauterine life, newborn, adult, elderly),
· to examine immune defense mechanisms against infections from viruses, bacteria, fungi, protozoa and metazoa,
· to know the role of the immune system in transfusions, in the rejection of transplants and in neoplastic diseases,
· to examine the etiopathogenetic foundations of the main immunopathological conditions (allergies, autoimmunity, immunodeficiencies).
· to know the principles of diagnostic tests described on immunological techniques
Course syllabus and organization

Single session

Course syllabus
1. The general organization of the immune system
2. B and T lymphocyte receptors and antigen recognition
3. The molecules of the Major Histocompatibility Complex (MHC) and the antigen presentation function
4. Antigen processing and presentation to T lymphocytes
5. The antigens
6. Activation of T helper lymphocytes
7. Activation of B lymphocytes and secretion of antibodies
8. Activation of cytotoxic T lymphocytes
9. NK and NKT cells
10. The central and peripheral organs of the immune system
11. Immunological tolerance
12. The effect mechanisms of immune responses
a. The complement system
b. Cytokines
13. Immunity in anti-infectious defenses
14. Immunity and the problem of transplants
15. Immunity and the problem of cancer
16. Immunity as a cause of disease
a. Allergic reactions of an immediate type
b. Allergic reactions of delayed type
c. Autoimmunity and autoimmune diseases
d. Immunodeficiency syndromes
17. Examples of immunological techniques applied to medicine
a. The antigen-antibody reaction in vitro
b. The immunofluorescence technique
c. The production of monoclonal antibodies
Prerequisites for admission
For the understanding of the course, notions of Anatomy, Histology, Biology, Genetics, Biochemistry, and elements of General Pathology and Microbiology are needed.
Teaching methods
The course consists of a single module, delivered in the form of lectures and exercises in small groups (4 exercises of 4 hours each) in the classroom and in the laboratory.
The teaching material relating to the lessons and exercises is made available to students through the Ariel website
Teaching Resources
Immunologia cellulare e molecolare
A. K. Abbas and A. H. Lichtman
Elsevier Masson

Immunobiologia
Janeway
Kenneth Murphy
9a edizione
PICCIN

Il sistema immunitario
P. Parham
EdiSES

Immunologia
M. Roitt and P.J. Delves
10th Edition - Blackwell Science Ed.
Antonio Delfino Editore
Assessment methods and Criteria
- The learning verification method consists of a single written test
- The written test consists of 60 multiple choice questions
- 1 point is awarded for each correct answer. To pass the written test it is necessary to score at least 36/60 points.
The evaluation will be calculated using a curve based on the maximum number of correct answers achieved within each individual exam session
- The results are communicated directly to the student via email sent by the online exam registration system
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 5
Informal teaching: 16 hours
Lessons: 48 hours
Shifts:
Gruppo 1
Professor: Trabattoni Daria Lucia
Gruppo 2
Professor: Trabattoni Daria Lucia
Gruppo 3
Professor: Trabattoni Daria Lucia
Gruppo 4
Professor: Trabattoni Daria Lucia
Gruppo 5
Professor: Trabattoni Daria Lucia
Professor(s)