Instrumental analytical chemistry applications

A.Y. 2019/2020
Overall hours
Learning objectives
The course highlights the analytical application of powder diffraction and thermal analysis in material chemistry and furnishes the basic notions of Mass Spectrometry and Nuclear Magnetic Resonance spectroscopy for the structural elucidation of organic compounds.
Expected learning outcomes
At the end of the course the student will be able to:
-interpret thermal events in DSC and TGA analyses
-interpret powder diffraction patterns, use the crystallographic databases and perform simple quantitative and qualitative analyses on polycrystalline mixtures.
- interpret the result of a multivariate analysis
- interpret spectra and to identify the structure of simple organic compounds from 1H and 13C NMR and MS spectra.
Course syllabus and organization

Single session

Course syllabus
Principles of diffraction analysis, practice of diffraction analysis, qualitative and quantitative phase analysis, ICDD Powder diffractions files, NIST standard reference materials, microstructure characterization. Examples of industrial applications of powder diffraction in the field of pharmaceuticals and materials. Thermal analysis: principles. Thermogravimetry and differential scanning calorimetry. Principles of multivariate analysis.

Principles of Mass Spectrometry (MS), structural determination of organic compounds, applications of HPLC-MS. Fundamentals of 1H and 13C NMR spectroscopy. Chemical shift and spin coupling. Dependence of chemical shift and spin coupling from the structure of organic compounds. NMR monodimensional techniques. Interpretation of NMR ad MS spectra.
Prerequisites for admission
Knowledge of the basic concepts of organic chemistry and of molecular structure. Mathematics and numerical calculation (as per the first year program).
Moreover, for this course, the following curses are suggested as prerequisites:
Organic chemistry I and II
General and inorganic chemistry
Mathematics I
Teaching methods
Frontal lesson with projected slides andwith the support of the blackboard. Interaction with the class via smartphone APP with easy questions and anonymous answers to evaluate the understanding of the topics in real time.
Hands-on sessions with computers to apply the methods learned in class on real case studies.
Teaching Resources
- Analisi di Materiali Policristallini Mediante Tecniche di Diffrazione, Guagliardi & Masciocchi Ed.s, Insubria University Press, Varese 2007.
- Guida Pratica alla Interpretazione di Spettri NMR, Antonio Randazzo, Loghia, 2018
- Lecturers notes
Assessment methods and Criteria
Verification of learning by written exam: the exam is organized in a written test with a maximum value of 30/30 (thirty). The test will be divided into two parts, one part will concern the program carried out on diffraction and one part will concern MS and NMR. Each part will consist of questions on theory and exercises and will award 15 (fifteen) points.
CHIM/01 - ANALYTICAL CHEMISTRY - University credits: 6
Lessons: 48 hours
Friday from 11.30 to 13.30