Molecular and Cellular Pharmacology and Experimental Pharmacology

A.Y. 2019/2020
8
Max ECTS
96
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The objective of the course is:
- To acquire knowledge about the main pharmacological targets at cellular and molecular level.
- To acquire knowledge about the most relevant in vitro and in vivo experimental models of preclinical pharmacology
- To acquire knowledge about the most relevant experimental techniques of preclinical pharmacology
Expected learning outcomes
At the end of the course, the student will have to know
- the molecular and cellular mechanisms in which the main pharmacological targets are involved
- the techniques available to characterize such biological pathways.
- the main fundamentals of experimental and preclinical pharmacology
- the main techniques used in experimental pharmacology laboratories
Course syllabus and organization

Single session

Responsible
Lesson period
Second semester
Prerequisites for admission
Knowledge of Pharmacology
Assessment methods and Criteria
Written test + oral presentation of a scientific publication
Molecular and Cellular Pharmacology
Course syllabus
Study of the main pharmacological targets: receptors and channels, structure and function, post-translational modifications, enzymes, proteases and adhesion molecules, synaptic plasticity mechanisms.
Teaching methods
Frontal teaching (16 hours) and laboratory of preclinical pharmacology (32 hours)
Teaching Resources
Slides and other material provided from the professor
Experimental Pharmacology
Course syllabus
Use of PubMed, Entrez, Blast, Genecards and other related websites for protein and gene analysis. Scientific publications. Research integrity. In vitro methods of experimental pharmacology: use of cell lines and primary cultures. Human induced pluripotent stem cells (iPSCs) and their use as disease model. Organoids.
Use of animal models, transgenic animals. In vivo behavioural experiments.
Microscopia confocale.
New techniques for genome editing: CRISPR/Cas9.
Teaching methods
Frontal teaching (16 hours) and laboratory of preclinical pharmacology (32 hours)
Teaching Resources
Slides and other material provided from the professor
Experimental Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Practicals: 32 hours
Lessons: 16 hours
Professor: Gardoni Fabrizio
Molecular and Cellular Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Practicals: 32 hours
Lessons: 16 hours
Professor: Marcello Elena
Educational website(s)
Professor(s)
Reception:
Monday 9.00 a.m.
Via Balzaretti 9, DiSFeB