The aim of course is to provide exhaustive knowledge of molecular and cellular mechanism of actions of drugs and to provide information on pharmacological modulation of cellular response, molecular aspects of receptors, modulation of intracellular signaling and gene expression. Drug is considered not only for its therapeutic function but also as a tool to investigate biological phenomena. Immunology is a rapid growing field of research in medicine and attracts a lot of attention for its contribution in various diseases such as infection diseases, cancer and auto-immunity. The course will give the student the opportunity to enhance the knowledge on rapidly evolving aspects within the field of immunology. This is an advanced course in the field of immunology, and will go into depth, particularly on molecular details.
At the end of the course the student will know the more recent advances in the field of pharmacology and immunology.
Expected learning outcomes
Lesson period: First semester
(In case of multiple editions, please check the period, as it may vary)
Students will encounter the following topics in the pharmacology and immunology fields: Molecular Pharmacology and molecular immunology Pharmacogenetics The pharmacology of signal transduction. Kinase inhibitors as antitumor drugs. Monoclonal antibodies and soluble receptors as drugs Transporters as drug targets The pharmacology of post translational modifications Immunosuppressants and immunostimulants The endocannabinoid system Excitatory amino acids and excitotoxicity The physiopathology of pain and analgesics G protein receptor regulation Chemotherapy of microbial diseases and drug resistance Chemotherapy of neoplastic diseases Vaccinations Allergic diseases Autoimmune diseases Microbiota and the immune system Cancer Immunotherapy Immunodeficiencies (AIDS and Kaposi sarcoma).
Prerequisites for admission
Basic knowledge of anatomy and human physiology.
Traditional, power-point assisted lectures to which attendance is highly suggested and, to encourage active student participation, Journal Clubs/review discussions with the required participation of all students.
Cellular and Molecular Immunology (AK Abbas e AH Lichtman, Elsevier, 2017 Basic and clinical pharmacology (Katzung, Piccin). Scientific papers and articles cited during the courses will be made available through the course Ariel website.
Assessment methods and Criteria
Written exam on the topics presented during the course: open questions in order to better assess the comprehension of the students, and the ability to make connections and to write in a correct scientific language (75% of the final grade). The Immunology part will also involve oral presentations carried out during the course (journal clubs, 25% of the final grade). The final grade will represent the students' joint evaluation by both teachers.