Pharmacology

A.Y. 2019/2020
10
Max ECTS
120
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The course aims to provide the student with the knowledge related to the mechanism of action, therapeutic action, adverse reactions and the use of drugs in the treatment and prevention of diseases. To do this the course will provide students with the essential concepts and tools for understanding and knowing:
- the principles of drug interaction with their receptors and their effect at the level of cells, tissues and the body (pharmacodynamics);
- the processes of absorption, distribution, metabolism and elimination of drugs within the body (pharmacokinetics) and the bases of possible drug interactions;
- the genetic basis (pharmacogenetics) and not of the interindividual variability of drug response;
- the principles of the development of new drugs, clinical trials and pharmacovigilance;
- the main classes of drugs active on the different organs and systems and the main classes of chemotherapeutic drugs.
Expected learning outcomes
At the end of the course the student should be able to learn about the therapeutic use of the different classes of drugs based on the knowledge of the molecular and cellular mechanisms of their action, the fundamental principles of pharmacodynamics, pharmacokinetics and variability of response in relation to gender, genetic and pathophysiological factors. Furthermore the student should be able to read and interpret the therapeutic schemes paying particular attention to the possible drug interactions and adverse reactions.
Course syllabus and organization

Single session

Course syllabus
1. General pharmacology
Introduction and history of pharmacology
Drug-receptor interactions
Receptors and signal transduction
Pharmacology of the cholinergic system
Pharmacology of the adrenergic system
2. Clinical pharmacology
Pharmacokinetics
Drug interactions
Pharmacovigilance
Clinical toxicology
Pharmacogenetics
Regulaion in drug development
Complementary medicines
3. Cardiovascular and pulmonary pharmacology
Organic nitrates nitric oxide
ACE inhibitors
Anticoagulants and fibrinolytics
Calcium antagonists
Diuretics
Antiarrhythmics
Pharmacological therapy of asthma and chronic obstructive pulmonary disease
4. Gastrointestinal pharmacology
Anti-vomiting, prokinetic, antihistamine and anti-ulcer drugs
Pharmacological therapy of inflammatory bowel diseases
5. Drugs of the immune system and inflammation
Corticosteroids
NSAIDs
Immunomodulatory drugs
6. Neuropsychopharmacology
The opioid system
Psychosis and mania therapy
Parkinson's disease and Alzheimer's therapy
Epilepsy therapy
Serotonergic system and therapy for depression and anxiety
General and local anesthetics
7. Pharmacology of the endocrine system
Estrogens and progestins and osteoporosis therapy
Diabetes mellitus and obesity therapy
Therapy of dyslipidemia
8. Chemotherapy
Introduction to chemotherapy and its problems
Beta-lactam
Sulfonamides, quinolones, tetracyclines and macrolides
Chloramphenicol e aminoglycosides
Anti-tuberculosis therapy
Antiviral therapy
Anticancer therapy
Prerequisites for admission
Knowledge of biomedical sciences and pathophysiology
Teaching methods
Frontal teaching supported by powerpoint presentations
Teaching Resources
Goodman & Gilman, Le basi farmacologiche della terapia, editore Zanichelli
AA VV Farmacologia generale e molecolare a cura di F. Clementi e G Fumagalli, editore Edra SpA
Katzung, Farmacologia generale e clinica, editore Piccin
Rossi, Cuomo, Riccardi: Farmacologia. Principi di base e applicazioni terapeutiche, editore Minerva Medica.
Assessment methods and Criteria
Oral examination. The exam is a discussion aimed at ascertaining the level of knowledge, the property of language, the understanding reached by the student and the ability to report on the discipline in an integrated way.
BIO/14 - PHARMACOLOGY - University credits: 2008
Lessons: 120 hours