Applied research and quality assessment methodologies

A.Y. 2020/2021
Overall hours
BIO/11 M-FIL/03 SECS-S/02 SECS-S/05
Learning objectives
Use and apply epidemiological and statistical methods and tools for:
- Evaluate the quality of the services provided within the technical health disciplines;
- Plan and carry out applied research in the field of technical health disciplines.
Expected learning outcomes
At the end of the course students will be able to:
understand the content of scientific publications in the sector;
prepare the documentation for the authorization of the research studies of the Ethics Committee;
build questionnaires for data collection for social research activities;
understand the quality of the services provided in the health sector and the tools available for its evaluation;
understand the results of interventions in the field of research and health promotion;
know about some research activities in the health prevention disciplines.
Course syllabus and organization

Single session

Lessons will be delivered remotely or in person or in mixed mode. Remote teaching will be delivered using the live MS TEAMS platform and recording of the lessons, which will then be available to students.
The mode of delivery of the lessons may undergo changes that will depend on the evolution of the health situation.
Prerequisites for admission
It is required to pass the exams of the computer science and statistics and epidemiology courses
Assessment methods and Criteria
The profit exam will consist of several modules.
A written test consisting of multiple choice questions will be proposed with the addition of some open questions, including the analysis, from a legal and moral point of view, of a practical case.
A group work led by the teacher on the critical analysis of articles in the scientific literature will be evaluated with the reworking of the content in slides and the oral presentation of the paper.
Molecular biology
Course syllabus
- Introduction to the structure and formation of life's macromolecules and to cellular bioenergetics
- Structure and function of proteins
- From DNA structure to genes, genomes and chromatin
- Conservation of DNA: replication and mechanisms of DNA repair
- Production of proteins: from genes' transcription t protein synthesis
- Visualization of proteins and DNA sequencing
- Pathological implications
Teaching methods
The teachings will include lectures with discussion of case studies and group work led by the teacher.
Teaching Resources
- Biologia Molecolare della Cellula di Bruce Alberts, Alexander Johnson, Julian Lewis
Moral philosophy
Course syllabus
Definition of "ethics"; Ethical theories; Moral codes and legal codes; Principles of medical ethics; Doctor-patient relationship; Relations with colleagues; Research Integrity and ethical committees; The argumention in ethics; What it means to do the right thing; Tragic choices and the concept of lesser evil; Right to health; Informed consent (details); Medical liability; Defensive medicine; Distribution of resources.
Teaching methods
The teachings will include lectures with discussion of case studies and group work led by the teacher.
Teaching Resources
Del Bò, Etica del turismo, Carocci, 2017, chaper 2 only, more the material available online (, that will be indicated at the first lesson
Statistics for experimental and technological research
Course syllabus
1) Occupational cancers:
· characteristics used to define an occupational tumor (target organ, histotype, latency, dose-response relationship, interaction between occupational carcinogen and other risk factors)
· Surveillance of occupational cancers in Italy: aims, methodologies, concrete examples of results (Mesothelioma and nasal sinus cancer register, active search for tumors with the lowest etiological fraction).
2) The scientific article:
· Explanation of the structure of the scientific article and methods of critical reading;
· Subdivision of the class into four groups and delivery of 3 recent articles on occupational cancer surveillance to each group. The content of the articles covers practical examples and different methodological approaches for the research / surveillance of occupational cancers.
· Critical reading of the articles and preparation of summary slides that will be presented to colleagues.
Teaching methods
The teachings will include lectures with discussion of case studies and group work led by the teacher.
Teaching Resources
- PA Bertazzi. Medicina del Lavoro. Cortina editore.
- Articoli forniti per il lavoro di gruppo:
· Oddone E., et al. Approcci allo studio delle neoplasia occupazionali a bassa frazione eziologica. GIMLE 2016; 38(4):311-314.
· Porru S., et al. Reducing the underreporting of lung cancer attributable to occupation: outcomes from a hospital based systematic search in Northern Italy. Int Arch Occup Environ Health (2016) 89:981-989.
· Ferrante P., et al. I sistemi nazionali di sorveglianza dei casi di mesotelioma. Epidemiol Prev 2016; 40(5): 336-343.
· Van Gerwen M et al. An overview of existing mesothelioma registries worldwide, and the need for US Registry. Am J Ind Med 2019; 1-6, DOI: 10.1002/ajim.23069.
· Consonni D, De Matteis S. Cancro e lavoro: stime di impatto mondiali. Epidemiol Prev 2017; 41(5-6): 308-309.
· Mensi C, et al. Ricerca sistematica dei tumori professionali: il Registro Tumori dei Seni nasali e paranasali della Lombardia. Med Lav 2010; 101(1): 19-25.
· Mensi C, et al. Il Registro Mesoteliomi Lombardia, Centro operativo regionale (COR) del registro nazionale mesoteliomi: aspetti organizzativi. Epidemiol Prev 2007; 31(5): 283-289.
Social statistics
Course syllabus
· Statistical sources
· Quantitative vs. qualitative research
· Interview questionnaires and overall research design
· Main elements of a research
· Questions and alternative answers
· Psychological processes underlying the understanding of questions and answers
· Techniques for administering the questionnaire
· The role of the interviewer and data collection
· Construction and verification of the measuring instrument and data analysis
· Qualitative techniques: participant observation; the qualitative interview
Teaching methods
The teachings will include lectures with discussion of case studies and group work led by the teacher.
Teaching Resources
- Corbetta Piergiorgio, Metodologia e tecniche della ricerca sociale, Il Mulino, 1999. (Parte prima: Ricerca quantitativa e qualitativa; Parte seconda: capitolo 8; Parte terza: capitoli 10, 11)
- Zammuner Wanda Lucia, Tecniche dell'intervista e del questionario, Il Mulino, 1998
- Material distributed in class
Molecular biology
BIO/11 - MOLECULAR BIOLOGY - University credits: 2
Lessons: 16 hours
Professor: Pasini Diego
Moral philosophy
M-FIL/03 - MORAL PHILOSOPHY - University credits: 1
Lessons: 8 hours
Professor: Poggi Francesca
Social statistics
SECS-S/05 - SOCIAL STATISTICS - University credits: 2
Lessons: 16 hours
Statistics for experimental and technological research
Lessons: 32 hours