Applied Toxicology in animal production

A.Y. 2020/2021
6
Max ECTS
48
Overall hours
SSD
VET/07
Language
Italian
Learning objectives
The aim of the course is to give to the student the knowledge of xenobiotics with toxic activity for the animals, with particular reference to the mechanisms of action. In addition, basic toxicological risk assessment concepts for food of animal origin will be provided.
Expected learning outcomes
At the end of the course the student must be able to describe the toxicological characteristics of the main xenobiotics that can enter the livestock production cycle
Course syllabus and organization

Single session

Responsible
Lesson period
Second semester
TEACHING METHODS Lectures and exercises will be held in person according to the published calendar and the indications given by the University. In the emergency phase, where attendance will not be possible, the lessons and exercises will be carried out through the Microsoft Teams platform. The teaching material will be made available on Ariel.
Information on the organization of lessons and how to access Microsoft Teams and any other information on teaching will be available on the ARIEL website of the course: it is therefore recommended to consult it regularly. Based on the evolution of the epidemic and in compliance with the relevant regulations, it will be possible to modify the modalities of the activities planned in the classroom, informing the students through ARIEL.
PROGRAM AND REFERENCE MATERIAL
The teaching program and reference material will not be affected.
LEARNING VERIFICATION METHOD Learning is verified through an oral test in presence where possible, otherwise, it will be verified through an oral exam using the Microsoft Teams platform.
Course syllabus
Introduction: chapters and purposes of toxicology, history of toxicology, classification and source of poisons (6 h)
Toxicocinetics exposure, absorption, distribution, metabolism, excretion (4 h)
Toxicodynamics and mechanisms of action of toxic substances (2 h)
Exogenous and endogenous factors that affect the toxicity of poisons (2 h)
Lethal dose (DL 50) - Maximum Tolerated Dose in large animals (2 h)
Experimental models and meaning of "Subacute Toxicity" and "Chronic Toxicity" (2 h)
Specific toxicity: mutagenicity, carcinogenicity, teratogenesis, reproduction effects (2 h)
Determination of threshold values (DGA, ADI, TDI, TWI etc.) (2 h)
Determination of the tolerance level - MRL (2 h)
Characterization management and communicationof of the risk (2 h)
Pesticides (8 h)
Poisoning by metals or minerals (6 h)
Poisonings from toxic plants (2 h)
Poisoning from mycotoxins (4 h)
Poisoning from non-proteic nitrogen compounds (2 h)
Prerequisites for admission
Knowledge of chemistry and biochemistry are required.
Teaching methods
The course includes lectures, held in the classroom.
Teaching Resources
The material used in the classroom for explanations will be present on the UNIMI Ariel portal.
Books
Mengozzi-Soldani (2010) Tossicologia Veterinaria, Idelson-Gnocchi
GUPTA R.C. (2018) Veterinary toxicology 3rd Ed- edited by Elsevier Academic Press.
Assessment methods and Criteria
Verification of learning is carried out through a written examination with open questions concerning special general toxicology.
VET/07 - VETERINARY PHARMACOLOGY AND TOXICOLOGY - University credits: 6
Lessons: 48 hours
Professor(s)
Reception:
By appointment from Monday to Friday
Dep. VESPA