Cancer immunology (ONC)

A.Y. 2020/2021
Overall hours
MED/04 MED/06 MED/15
Learning objectives
Acquisition of immunosurveillance and immunoevasion concepts, knowledge of the biological basis of the tumor escape mechanisms, understanding of the biological rational understanding of the most used approaches for the modulation of the immune response with anti-cancer purposes.
Expected learning outcomes
Specific knowledge on the relationship between the host's immune system and the tumor and the main anti-tumor approaches based on immunomodulatory strategies.
Course syllabus and organization

Single session

Lesson period
Third trimester
All classes planned during the third trimester of the first year of the Master Degree Medical Biotechnology and Molecular Medicine, will be given as frontal teaching and distance synchronous learning. In case of a new suspension of frontal lectures, all students will be asked to move to distance synchronous learning.
Each hour of lesson will be divided into 45' of formal teaching followed by 15' of discussion/interaction/question time. All lessons will be recorded and made available for students on the indicated platforms (i.e. Ariel, TEAMS, etc).
Unless otherwise specified, exams will be organized in classroom but if the student is unable to reach the building for COVID-related issues, other forms will be considered (this apply for exams scheduled until the 31st July - 2021).
Course syllabus
General pathology and immunology:
The immune system in the tumor microenvironment: Inflammation in tumor progression; Functional role of tumor-associated leukocytes and other host cells; Immune infiltrate and tumor angiogenesis; Effects of the tumor on local and systemic immune regulation; Tumor-associated regulatory T cells; Tumor-associated suppressor cells of the myeloid lineage (MDSC, TAM, TAN); Tertiary lymphoid structures in the tumor; Therapeutic approaches targeting the tumor microenvironment.
Medical oncology:
Cancer immunology and immunotherapy in solid tumors: History and principles of immune cancer treatment; Predictors of response to immune therapies; Development of anticancer immune agents;
Evidence of efficacy of immune therapies; Immunotherapies in different models of solid cancers; T-cell therapies; Cancer vaccines; Future trends in cancer immune therapy; Toxicity of cancer immune therapies; Sustainability of anticancer agents.
Blood diseases:
Cancer immunology and immunotherapy in hematological tumors: The role of checkpoint inhibitors in Lymphomas; Adoptive immunotherapy for cancer (CAR T cells); Allogenic hematopoietic stem cell transplantation as adoptive immunotherapy in cancer; The targeting of cancer microenvironment (T-reg, MDSC, NK, Dendritic, macrophages): the paradigma of multiple myeloma; The role of the B-cell receptor signaling in lymphoid malignancies.
Prerequisites for admission
There is no specific preliminary knowledge
Teaching methods
Frontal lessons based on teaching material available on the Ariel platform or provided directly in the classroom to students.
Class attendance is free.
Teaching Resources
PDF files of the lessons. Review article on different topics.
Assessment methods and Criteria
Exam based on a written test consisting of 30 closed-ended questions relating to different modules of the program. The test takes place in 1 hour. The basic knowledge of the discipline is assessed. The evaluation is expressed in thirtieths, the results are communicated through the University registration system.
Blood diseases
MED/15 - BLOOD DISEASES - University credits: 2
Lessons: 14 hours
General pathology and immunology
Lessons: 14 hours
Medical oncology
MED/06 - MEDICAL ONCOLOGY - University credits: 2
Lessons: 14 hours
Professors: Pietrantonio Filippo, Siena Salvatore
Educational website(s)
by appointment +39 02 6444.2291
Ospedale Niguarda, Piazza Ospedale Maggiore 3,Milano