Chemotherapy and Biological Drugs
A.Y. 2020/2021
Learning objectives
The course program includes the teaching of: 1) biochemical and pharmacological properties, production methods and clinical indications for biotechnological drugs; 2) mechanism of action, pharmacology and clinical toxicology of anti-infective, anti-tumor and immunoregulatory chemotherapeutics. The aim of the course is to provide the knowledge on the rational bases for the development and clinical use of these classes of drugs and to contribute to the formation of professionals with the cultural and practical skills necessary for the future occupational opportunities within the health area.
Expected learning outcomes
Students 1) know the mechanisms by which biotechnological and chemotherapeutic drugs act; 2) know the methodologies for the synthesis of biotechnological drugs; 3) are able to predict the pharmacodynamics and pharmacokinetics of biotechnological and chemotherapeutic drugs; 4) know the classes of drugs available for the different therapeutic areas; 5) are able to predict adverse reactions associated with the use of biotechnological and chemotherapeutic drugs
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Linea AL
Responsible
Lesson period
First semester
The lessons will be held in part in attendance, with participation methods and criteria that will be published in time on the Ariel page of the course, and in part on the Microsoft Teams platform, which can be followed syncronously, as established in the official timetable, and asynchronously as lessons will be recorded and left available to students on the same Teams platform and on the Ariel page of the course.
The teaching method can be updated according to the evolution of the legislation imposed by Covid-19, as well as the methods of verification that may undergo changes, eliminating the written test and moving the oral test to Microsoft Teams. These updates will be communicated in time on the Ariel pages. The program and reference material will not change
The teaching method can be updated according to the evolution of the legislation imposed by Covid-19, as well as the methods of verification that may undergo changes, eliminating the written test and moving the oral test to Microsoft Teams. These updates will be communicated in time on the Ariel pages. The program and reference material will not change
Course syllabus
1. CHEMOTHERAPY OF MICROBIAL DISEASES
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza
1.4.2 Coronavirus and pharmacological treatments
1.5 Clinical use
1.5.1 Guidelines for the correct clinical use of antibiotics
1.5.2 Antibiotic associations
1.5.3 Antibiotic prophylaxis
1.5.4 Mechanisms of resistance
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
4.2 Immune stimulating agents
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza
1.4.2 Coronavirus and pharmacological treatments
1.5 Clinical use
1.5.1 Guidelines for the correct clinical use of antibiotics
1.5.2 Antibiotic associations
1.5.3 Antibiotic prophylaxis
1.5.4 Mechanisms of resistance
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
4.2 Immune stimulating agents
Prerequisites for admission
"Applied Microbiology and Hygiene" ("Microbiologia applicata ed Igiene") and "Pharmacology and Pharmacotherapy" ("Farmacologia e Farmacoterapia").
Teaching methods
Slides available on the Ariel website
Teaching Resources
FARMACI BIOTECNOLOGICI. Aspetti farmacologici e clinici dei medicinali biotecnologici
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Assessment methods and Criteria
The exam consists of a written part, delivered through tests (30 multiple choice questions) at the university IT offices, and an oral part. Admission to the oral exam is subject to passing the written test (at least 20 correct answers).
Linea MZ
Responsible
Lesson period
First semester
The lessons will be held in attendance or through Microsoft Teams, Zoom Meeting or other platforms in asynchronous or synchronous transmission.
The program and the teaching material will be the same.
The exam will be oral using Microsoft Teams, Zoom Meeting or other platforms; if allowed by the emergency rules, it might be in presence as oral.
The program and the teaching material will be the same.
The exam will be oral using Microsoft Teams, Zoom Meeting or other platforms; if allowed by the emergency rules, it might be in presence as oral.
Course syllabus
1. CHEMOTHERAPY OF MICROBIAL DISEASES
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza
1.4.1 Coronavirus and drug therapies
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
3.2 Immune stimulating agents
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza
1.4.1 Coronavirus and drug therapies
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
3.2 Immune stimulating agents
Prerequisites for admission
"Applied Microbiology and Hygiene" ("Microbiologia applicata ed Igiene") and "Pharmacology and Pharmacotherapy" ("Farmacologia e Farmacoterapia").
Teaching methods
Slides available on the Ariel website
Teaching Resources
FARMACI BIOTECNOLOGICI. Aspetti farmacologici e clinici dei medicinali biotecnologici
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Assessment methods and Criteria
The exam consists of a written part, delivered through tests (30 multiple choice questions) at the university IT offices, and an oral part. Admission to the oral exam is subject to passing the written test (at least 20 correct answers).
Professor(s)