Ethiopathogenesis of Hereditary and Parasitic Diseases

Unit H52-79-A: Genomic analysis of inherited diseases
LECTURES:
- Genetic and physical maps of domestic animals (2 hs).
- Genome Wide Sequencing High-throughput systems, DNA and RNA sequencing (4 hs)
- Whole genome amplification, SNP array and Genome Wide Association Studies for genome mapping of inherited diseases (4 hs)
- Genomic variability and host-parasite interaction: Leishmaniosis and Varroatosis (2 hs)

PRACTICALS:
- On-line practice on Genomic databases (3).
- Journal clubs on genome sequencing project in domestic animals, genome mapping (Homozigosity mapping, case / control studies, trios) and gene identification in inherited
diseases and in parasitic diseases, the latter limited to those addressed in the lectures (3).
- Visits to research and service centers equipped with high-throughput platforms (6).

Unit H52-79-B: Molecular pathology of parasitic diseases.
LECTURES:
1. Advanced diagnostic techniques for the study of the molecular mechanisms of parasitic diseases (2 hs)
2. Immunopathology of parasitic diseases and parasitic strategies of immune response evasion: leishmaniosis and filariosis (4 hs)
3. Drug targets of parasites - insights from genome mining and animal models (2 hs)
4. Moonlighting proteins of parasites: physiopathological significance (2 hs)
5. Molecular mechanisms of resistance and sensitivity to animal parasitic diseases: varroatosis, toxoplasmosis and neosporosis (2 hs)

PRACTICALS:
The practical part of the course will teach the student the application of methods described in the lectures and specifically, genetic expression and molecular diagnostic techniques applied to the study of parasitic diseases and related animal models (12 hs)