Microbiology and pathology

A.Y. 2020/2021
6
Max ECTS
63
Overall hours
SSD
MED/04 MED/07 MED/09
Language
Italian
Learning objectives
To know the fundamentals of the pathophysiology applicable to different clinical situations, also in relation to diagnostic parameters
To know the causes of diseases in humans, as well as the fundamental pathogenetic and pathophysiological mechanismsTo know the basics of microbiology
To know the relationships between microorganisms and host in human infections
To know the principles of semeiotics
Expected learning outcomes
Know the main causes of illness and the mechanisms by which pathogens induce diseases; the student will have acquired the fundamentals of pathophysiology, microbiology and the principles of semeiotics.
Course syllabus and organization

Single session

Responsible
Lessons only in TEAMS platform
Prerequisites for admission
There are no prerequisites
Assessment methods and Criteria
Multiple choice test with also open questions
All the exams take place on the same day.
Experimental medicine and pathophysiology
Course syllabus
CELLULAR PATHOLOGY
Cellular adaptations
Intracellular accumulations: Steatosis
Cell damage
Biochemical mechanisms of cell damage
Ischemia and reperfusion injury
Necrosis
Apoptosis

ENVIRONMENTAL PATHOLOGY
Chemical agents and physical agents as cause of disease

THE INFLAMMATORY RESPONSE
Acute inflammation:
Alterations of microcirculation and cellular events
Chemical mediators of acute inflammation

Chronic inflammation:
Interstitial inflammation
Granulomatous inflammation: tuberculosis, foreign body granuloma

The pneumoconiosis

The systemic response to damage

The reparative process

IMMUNOLOGY AND IMMUNOPATHOLOGY
General aspects of the innate and acquired immune response
Cells and organs of the immune system
Antigen recognition
Humoral and cell-mediated immune responses
Hypersensitivity reactions
Autoimmunity

NEOPLASTIC DISEASES
Control of cell growth and non-neoplastic disturbances of cell proliferation
Neoplastic growth: characteristics of benign and malignant neoplasms
Nomenclature and classification criteria for tumors
Mechanisms of local invasion and metastasis
The molecular basis of tumors: oncogenes and tumor suppressors
Carcinogens and their cellular interactions: chemical, physical and microorganism carcinogenesis
Epidemiological aspects of tumors
Occupational cancer risk
Effects of cancer on the host
Teaching methods
Frontal Lessons
Teaching Resources
G.M. PONTIERI
ELEMENTI DI PATOLOGIA GENERALE
Per i Corsi di Laurea in Professioni Sanitarie
IV Edizione
PICCIN
Microbiology and clinical microbiology
Course syllabus
General microbiology
· Main differences between prokaryotic and eukaryotic microorganisms, viruses and prions.
· Transmission of microorganisms and viruses.Importance of vehicles and vectors. Main characteristics of pathogenicity and virulence.
· Main host/infectious agent interactions: colonization, symbiosis, commensalism, infection and disease. Factors influencing the infectious process.
· Main sterilization procedures, antisepsis, disinfection. Selection criteria for disinfectants and their application.
· Structure and functions of the different components of the bacterial cell. Cell wall of gram positive and gram negative bacteria. Gram and acid fast staining. Reproduction.Bacterial spore.
· Introduction to bacterial cell metabolism with reference to pathogenicity and identification criteria
· Mechanism of action of the main antibacterial drugs and microbial drug-resistance mechanisms.
· Criteria for the collection and transportation of biological samples for microbiological diagnosis in the laboratory
· Nosocomial infections: main sources of infection, risk factors, transmission pathways and most common pathogens

Special microbiology
· Main bacteria of clinical interest: Staphylococcus, Streptococcus, Pathogenic neisseries, enterobacteria, vibrions, sporigens, mycobacteria, leptospires and spirochetes. Mycoplasms, chlamydiae and ricketsie
. Notes on the main fungal agents with particular reference to the genera Candida, Cryptococcus and Aspergillus
· Notes on the main protozoa and helminths of human interest Plasmodium, Ameba,Trichomonas, Trichinella, Teniae)
· Origin, organization and replication of animal viruses. General classification of DNA and RNA viruses. Main agents of viral infections (Herpesviridae, Orthomyxoviridae, Paramyxoviridae, Picornaviridae) Retroviridae and liver viruses.
Teaching methods
Frontal Lessons
Teaching Resources
Slides used during lessons
Additional in-depth slides.
List of Microbiology texts for the health professions.
Internal medicine
Course syllabus
Course Syllabus:
- Approach to the patient with Cardiovascular Disease
- Approach to the patient with Disease of the Respiratory System
- Approach to the patient with Gastrointestinal Disease
Teaching methods
Frontal Lessons
Teaching Resources
Claudio Rugarli et coll. Medicina Interna Sistematica. Ed. Masson
Experimental medicine and pathophysiology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 3
Lessons: 30 hours
Professor: Bendinelli Paola
Internal medicine
MED/09 - INTERNAL MEDICINE - University credits: 1
Lessons: 10 hours
Professor: Branchi Adriana
Microbiology and clinical microbiology
MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY - University credits: 2
Practicals: 8 hours
Lessons: 15 hours