Organic Chemistry 2 and Organic Chemistry Laboratory

A.Y. 2020/2021
10
Max ECTS
112
Overall hours
SSD
CHIM/06
Language
Italian
Learning objectives
A sufficiently complete insight in the organic reactivity will be given to the student to develop a good knowledge of main reactions and the skill for their correct interpretation.
- The basic preparation will give to the student the ability to elaborate simple synthetic pathways and to fully understand the more complex ones.
- Enough information will be given to the student to understand organic reactions involved in biological processes.
- Provide basic skills for the development of chemical reactions by laboratory activities
Expected learning outcomes
- Knowledge of the main reactions by correctly interpreting the reaction mechanisms.
- Ability to develop simple synthetic patterns from reagents to products
- Use of the skills acquired to tackle advanced organic chemistry courses
- Acquisition of the basic skills necessary to synthesize an organic compound in the laboratory
Course syllabus and organization

Linea AK

Responsible
Lesson period
First semester
The lessons of the theoretical part will be held on the Microsoft Teams platform and can be followed both in synchrony and in asynchronous. The lessons will be recorded and left available to students.
Classroom exercises on organic synthesis (classroom to be defined):
18 November 8.30-12.30 (4 h)
9 December 8.30-12.30 (4 h)
Lab. activities:
- only 1/3 of the total credits will be carried out in lab.
- the remaining 2/3 of the total credits will be transformed into on-line lessons by using Microsoft TEAMS
Course syllabus
1 - Aromatic compounds. Chemistry of benzene and naphtalene, aromaticity, mechanisms of electrophilic and nucleophilic substitution, activating, deactivating and orienting effects of substituting groups. Understanding of main reactions of synthetic value. Some classes of compounds will be developed taking into account their specific importance.
2 - Chemistry of sulfur containing compounds
3- Enols, enolates, enamines, electron-poor alkenes, quinones: kinetics and thermodynamics of enolization processes, formation and stability of enolates and enamines; synthetic applications of aldol condensation reactions, Claisen condensation reactions, alkylation processes. Theory and use of the reactivity of eletron-poor alkenes.
4 - Heterocyclic compounds. A general picture of the reactivity of several important heterocyclic rings will be given to the student taking into account those essential for his career. Main synthetic pathways will be explained.
5 - Amino acids and peptides: properties of amino acids, their synthesis, protecting groups and principles of peptide synthesis.
6 - Exercises. Theoretical and practical problems will be proposed to the student and solved by direct free discussion.

Laboratory course:
Practical experiences (1/3 CFU) are preceded by the necessary theoretical explanations. - Realization of simple Organic Chemistry syntheses and learning of fundamental purification techniques: a) condensation; b) oxidation; c) multicomponent reaction; d) nucleophilic acyl substitution. All the syntheses are followed and controlled with the most appropriate analytical techniques and all the products obtained are subjected to adequate purification and characterization processes.
On-line lessons of the laboratory course (2/3 of the CFU), supported by numerous videos, designed to provide the student with the fundamental information to be able to perform the most common operations lab.activities such as: a) crystallization; b) distillation; c) chromatography; d) extraction. Specific but fundamental topics will be covered, such as: i) designing a chemical synthesis using the Sci-Finder database; ii) structural determination (infrared spectroscopy).
Prerequisites for admission
Knowledge of Organic Chemistry I
Teaching methods
Theoretical course: classroom lectures with explanation of the different course topics, followed by interactive exercises on the organic synthesis.

Laboratory practice on the synthesis of simple organic molecules
Teaching Resources
- Slides of the course on Ariel web (both for theoretical and lab. courses)
- - examples of written tests on the Ariel website
- Testi consigliati: K. P. C. Vollhardt, N. E. Schore, Chimica Organica, Ed. Zanichelli; - P. Y. Bruice Chimica Organica 3a ediz. Ed. Edises 2017 - S. Ege, Chimica Organica, Ed. Sorbona e relativo eserciziario; - J. McMurry, Chimica Organica, Ed. Piccin 9 Ed 2017- R. Norman, J. M. Coxon, Principi di sintesi organica, Ed. Piccin, capitoli scelti. - G. Broggini, G. Zecchi Chimica dei Composti Eterocicli, Ed Zanichelli 2017 - D. Sica, F. Zollo Chimica dei composti eterociclici farmacologicamente attivi, Ed. Piccin.
Assessment methods and Criteria
The evaluation of the theoretical course will be carried out face-to-face, if the regulation will allow it. If not possible, the Microsoft TEAMS platform will be used.
The test is divided in two parts:
- Written test (15 questions both of theory and applications; two hours; Marks: 0-2 for each question. Minimum to be achieved for oral exam: 17 marks)
- oral exam.
The lab evaluation is based on the quality of the practical experiences in lab. and a final report of lab. experiences
The final assessment of the exam is weighed on the basis of the CFU of the theoretical teaching unit (6CFU) and on the laboratory activity (4CFU).
Organic Chemistry 2
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor: Gelmi Maria Luisa
Organic Chemistry Laboratory
CHIM/06 - ORGANIC CHEMISTRY - University credits: 4
Single bench laboratory practical: 64 hours
Shifts:
Turno 1
Professor: La Rosa Concetta
Turno 2
Professor: Gelmi Maria Luisa

Linea LZ

Responsible
Lesson period
First semester
Theoretical lesson will be carried out online, using the Microsoft Teams platform.
The evaluation of the theoretical course will be carried out face-to-face, if the regulation will allow it. If not possible, the Microsoft TEAMS platform will be used.
Course syllabus
1 - Aromatic compounds. Chemistry of benzene and naphtalene, aromaticity, mechanisms of electrophilic and nucleophilic substitution, activating, deactivating and orienting effects of substituting groups. Understanding of main reactions of synthetic value. Some classes of compounds will be developed taking into account their specific importance.
2 - Chemistry of sulfur containing compounds
3- Enols, enolates, enamines, electron-poor alkenes, quinones: kinetics and thermodynamics of enolization processes, formation and stability of enolates and enamines; synthetic applications of aldol condensation reactions, Claisen condensation reactions, alkylation processes. Theory and use of the reactivity of eletronpoor alkenes.
4 - Heterocyclic compounds. A general picture of the reactivity of several important heterocyclic rings will be given to the student taking into account those essential for his career. Main synthetic pathways will be explained.
5 - Amino acids and peptides: properties of amino acids, their synthesis, protecting groups and principles of peptide synthesis.
6 - Exercises. Theoretical and practical problems will be proposed to the student and solved by direct free discussion.
Laboratory course:
Practical experiences (1/3 CFU) are preceded by the necessary theoretical explanations. - Realization of simple Organic Chemistry syntheses and learning of fundamental purification techniques: a) condensation; b) oxidation; c) multicomponent reaction; d) nucleophilic acyl substitution. All the syntheses are followed and controlled with the most appropriate analytical techniques and all the products obtained are subjected to adequate purification and characterization processes.
On-line lessons of the laboratory course (2/3 of the CFU), supported by numerous videos, designed to provide the student with the fundamental information to be able to perform the most common operations lab.activities such as: a) crystallization; b) distillation; c) chromatography; d) extraction. Specific but fundamental topics will be covered, such as: i) designing a chemical synthesis using the Sci-Finder database; ii) structural determination (infrared spectroscopy).
Prerequisites for admission
Knowledge of the topics treated in the course of organic chemistry I
Teaching methods
Theoretical course: classroom lectures with explanation of the different course topics, followed by interactive exercises on the organic synthesis.
Laboratory practice on the synthesis of simple organic molecules
Teaching Resources
- Slides of the course on Ariel web (both for theoretical and lab. courses)
- - examples of written tests on the Ariel website
- Testi consigliati: K. P. C. Vollhardt, N. E. Schore, Chimica Organica, Ed. Zanichelli; - P. Y. Bruice Chimica Organica 3a ediz. Ed. Edises 2017 - S. Ege, Chimica Organica, Ed. Sorbona e relativo eserciziario; - J. McMurry, Chimica Organica, Ed. Piccin 9 Ed 2017- R. Norman, J. M. Coxon, Principi di sintesi organica, Ed. Piccin, capitoli scelti. - G. Broggini, G. Zecchi Chimica dei Composti Eterocicli, Ed Zanichelli 2017 - D. Sica, F. Zollo Chimica dei composti eterociclici farmacologicamente attivi, Ed. Piccin.
Assessment methods and Criteria
The test is divided in two parts:
- Written test (15 questions both of theory and applications; two hours; Marks: 0-2 for each question.
Minimum to be achieved for oral exam: 17 marks
- oral exam.
The lab evaluation is based on the quality of the practical experiences in lab. and a final report of lab. experiences.
The final assessment of the exam is weighed on the basis of the CFU of the theoretical teaching unit (6 CFU) and on the laboratory activity (4 CFU).
Organic Chemistry 2
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Organic Chemistry Laboratory
CHIM/06 - ORGANIC CHEMISTRY - University credits: 4
Single bench laboratory practical: 64 hours
Shifts:
Turno 1
Professor: Erba Emanuela
Turno 2
Professor: Rossi Elisabetta