- Characterize the manifestation and mechanisms of toxicity - Provide scientific basis for experimental toxicology and criteria for evaluating and extrapolating toxicity data to humans - Provide adequate toxicological knowledge and valid bases for defining the criteria for protecting human health from the risks deriving from the direct (drugs, food additives, etc.) or indirect exposure (environmental pollutants, industrial solvents, etc.) of substances (chemical and biological).
Expected learning outcomes
Knowledge and understanding of the main aspects of toxicology with particular reference to general and organ toxicity of xenobiotics
GENERAL PRINCIPLES OF TOXICOLOGY · Principles of Toxicology · Mechanisms of Toxicity · Methods of in vitro toxicology NON-ORGAN-DIRECTED TOXICITY · Developmental toxicology · Genetic toxicology · Carcinogenesis TARGET ORGAN TOXICITY · Toxic responses of the respiratory system · Toxic responses of the immune system · Toxic responses of the Nervous System · Toxic responses of the kidney · Toxic responses of the liver · Toxic responses of the skin · Toxic responses of the heart · Toxic responses of the ocular and visual system CHEMICAL AND PHYSICAL AGENTS TOXICITY · Pesticides · solvents · radioactivity · Metals · Natural Toxins RISK ASSESSMENT · Risk assessment
Prerequisites for admission
Knowledge of basic human anatomy and principles of biology
The course is based on both lessons and active discuss on the content of each general chapter. Slides of the course are provided on Ariel web-site: https://ariel.unimi.it
· Tossicologia, Galli-Corsini-Marinovich, editore PICCIN, 2 Edizione (2008) · Casarett & Doull's -Tossicologia, Ed. Curtis D.Klaassen, 5° edizione (vers. italiana) EMSI - Roma · Tossicologia cellulare e molecolare, Ed. G. Cantelli Forti, P. Hrelia, C.L.Galli, M. Marinovich, UTET (2000) · Casarett & Doull's -Toxicology, The basic science of poisons, Fifth edition (1999), Ed. C.D. Klaassen , J.B. Watkins III°, McGraw Hill · General & Applied Toxicology, Ed. B. Ballantyne, T. Marrs, P. Turner, MacMillan Press
Assessment methods and Criteria
Aim of the course is to provide basic knowledge on the principles of toxicology through the characterization of the main mechanisms of toxicity at both cellular and organ level and through the mechanisms of differente classes of chemicals. Acquisition of these competences will be evaluated by oral examination on any topic of the program.