Cellular and Molecular Physiology
A.Y. 2021/2022
Learning objectives
The aim of the course is to deepen students' knowledge of cellular and molecular physiological mechanisms, especially in relation to excitable cells. Some examples of pathologies due to alterations in the molecular components of excitable cells will be examined with particular attention to ion channels and their interaction with the cytoskeleton, and other protein macro-molecular complexes. The teaching formula is that of "solving the problem". Students will learn a physiological mechanism that is made up of different interactions (e.g.: membrane potential, calcium release, activation of intracellular pathways) and how alteration of specific components can cause a pathophysiological state.
Expected learning outcomes
At the end of the course the student is expected to have acquired the critical ability to analyze, through the literature, the behavior of a physiological process that changes into a pathological state. The second goal is to integrate the basic knowledge of different disciplines to cope with a complex physiological problem.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Lesson period
First semester
The lectures will be held telematically on the Microsoft Teams platform and will be delivered synchronously (at set times). In particular cases they will be delivered asynchronously
Course syllabus
Bioelectricity phenomena in cells. Macromolecular complexes responsible for electrical communication between cells. Effect of changes in the passive properties of the membrane on cellular function. Molecular Basis of primary cardiac arrhythmias (channelopathies). Secondary channelopathies: roles of the cytoskeleton and membrane microdomains in the functionality of ion channels.
State-of-the-art cell systems to study complex pathologies. Effect of aging and training on the functionality of excitable cells. towards the development of a biological pacemaker.
State-of-the-art cell systems to study complex pathologies. Effect of aging and training on the functionality of excitable cells. towards the development of a biological pacemaker.
Prerequisites for admission
Basic knowledge of biophysics are requested
Teaching methods
Lectures, seminars and discussion of scientific articles.
Teaching Resources
B, Hille. Ion Channels In Excitable Membrane. Ed. Sinauer
Zipes Cardiac electrophysiology from cells to bedside
Zipes Cardiac electrophysiology from cells to bedside
Assessment methods and Criteria
The exam consists in a 15 minutes PPT presentation about a cellular and molecular physiology scientific publication in scientific journal with impact factor plus an oral examination.
BIO/09 - PHYSIOLOGY - University credits: 6
Lessons: 48 hours
Professors:
Barbuti Andrea Francesco, Brandalise Federico