The course program includes the teaching of: 1) biochemical and pharmacological properties, production methods and clinical indications for biotechnological drugs; 2) mechanism of action, pharmacology and clinical toxicology of anti-infective, anti-tumor and immunoregulatory chemotherapeutics. The aim of the course is to provide the knowledge on the rational bases for the development and clinical use of these classes of drugs and to contribute to the formation of professionals with the cultural and practical skills necessary for the future occupational opportunities within the health area.
Expected learning outcomes
Students 1) know the mechanisms by which biotechnological and chemotherapeutic drugs act; 2) know the methodologies for the synthesis of biotechnological drugs; 3) are able to predict the pharmacodynamics and pharmacokinetics of biotechnological and chemotherapeutic drugs; 4) know the classes of drugs available for the different therapeutic areas; 5) are able to predict adverse reactions associated with the use of biotechnological and chemotherapeutic drugs
Lesson period: First semester
(In case of multiple editions, please check the period, as it may vary)
1. CHEMOTHERAPY OF MICROBIAL DISEASES 1.1 General principles of antimicrobial therapy 1.2 Chemotherapy of bacterial infections 1.3 Treatment of HIV infection 1.4 Treatment of influenza 1.4.1 Coronavirus and drug therapies
2. BIOTECHNOLOGICAL DRUGS 2.1 Genetic engineering and pharmaceutical biotechnology 2.2 Recombinant proteins used in therapy 2.3 Fusion proteins 2.4 Monoclonal antibodies and derivatives 2.5 Fusion proteins 2.6 Nucleic acids as therapeutic agents 2.7 Advanced therapies 2.5 Pharmacokinetics of biotechnological drugs
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES 3.1 Cytotoxic drugs 3.2 Target therapy 3.3 Immune therapy in cancer 3.4 Hormonal therapy in cancer
"Applied Microbiology and Hygiene" ("Microbiologia applicata ed Igiene") and "Pharmacology and Pharmacotherapy" ("Farmacologia e Farmacoterapia").
Slides available on the Ariel website
FARMACI BIOTECNOLOGICI. Aspetti farmacologici e clinici dei medicinali biotecnologici Vegeto E, Maggi A, Minghetti P
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Farmacologia generale e clinica
Katzung & Trevor,
"Le basi farmacologiche della terapia
Goodman & Gillman
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Assessment methods and Criteria
The exam consists of a written part, delivered through tests (30 multiple choice questions) at the university IT offices, and an oral part. Admission to the oral exam is subject to passing the written test (at least 20 correct answers).