We will study causes and mechanisms of disease. To this end, we will examine the molecular, cellular and functional effects due to the occurrence of pathogenic events (such as genetic alterations, activation of cellular oncogenes). We will study cell damage, death, adaptation, and the systemic and local reaction to tissue damage, with an in depth analysis of the inflammatory reaction.
Expected learning outcomes
The student will acquire the knowledge tools to understand the fundamental causes of disease mechanisms, with dual focus on general aspects and on molecular mechanisms. She/he will learn the molecular, cellular and functional aspects at the basis of altered cellular states which lead to disease, including cancer.
Molecular and cellular aspects of cell damage: -Apoptosis and necrosis -Autophagy -Cell and organismal aging Genetic bases of disease -Gene therapy and genome editing Inflammation Cancer: -cancer cell properties -tumor heterogeneity -cancer stem cells and cancer plasticity -metastasis and angiogenesis
Prerequisites for admission
Teacher's lessons supported by slides.
Slides of the lessons will be made available on Ariel/MS Teams. Suggested texts: - Pontieri et al. Patologia generale e fisiopatologia generale - Volume 1 - Moncharmont et al. Patologia generale - Volume 1.
Assessment methods and Criteria
Written exams (Open questions on the course topics). Students attending the lessons and volunteering for the auxiliary test can sustain an oral exam that will consist of the preparation of a presentation (with the help of the teacher and in small working groups) regarding the program topics. In case of emergency, exams will be taken in oral form.