Pharmacology
A.Y. 2023/2024
Learning objectives
The main object of the course is to provide the theoretical and practical basis in order to understand drug action, explaining the concepts of pharmacodynamic and pharmacokinetic. Modern molecular pharmacology will be presented, explaining the molecular targets for drugs and the factors that can affect the therapeutic response. It will be clarified that the interaction drug/organism may have different meanings: (i) be aimed at amending a pathological condition (therapy); (ii) damage the organism (toxicant); (iii) be used to study the organism (medication as a study tool).
Expected learning outcomes
At the end of the course the student will have acquired and understood the basic knowledge in order to understand the interactions between the drugs and the organism. He will have sufficient knowledge of pharmacodynamics and pharmacokinetic to read in a correct and critical way the drug package insert. He will know the molecular mechanisms that can be modulated by drugs. The course is preparatory for the pharmacology courses of the third year, during which the student will apply the acquired knowledge to analyze the different drug classes in relation to pathological conditions.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Lesson period
Second semester
Course syllabus
In the educational course of Pharmacology we will cover the concept of Pharmacology, understood as the mutual interaction between a substance introduced into the body and the body itself. This interaction may have different meanings: (i) be aimed at amending a pathological condition (therapy); (ii) damage the organism (toxicant); (iii) be used to study the organism (medication as a study tool).The pathway of a drug from entering the body to its exit will be illustrated (Absorption, distribution, metabolism, elimination) in relation to its characteristics and those of the subjects assuming them (pharmacogenetics). Concept of dose-response, therapeutic index, descriptive pharmacokinetics.
The main knowledges on drugs mechanisms of action (pharmacodynamics), possible targets and drug-drug interactions are explained.
The pharmacodynamic concepts will be given.
Receptors. Quantitative aspects of drug interactions with receptors.
Structural and functional families of receptors and intracellular signalling.
Pharmacology of neurotransmission
Pharmacology of the renin-angiotensin system
Pharmacology of arachodonic acid metabolites
Elements of chemotherapy
The main knowledges on drugs mechanisms of action (pharmacodynamics), possible targets and drug-drug interactions are explained.
The pharmacodynamic concepts will be given.
Receptors. Quantitative aspects of drug interactions with receptors.
Structural and functional families of receptors and intracellular signalling.
Pharmacology of neurotransmission
Pharmacology of the renin-angiotensin system
Pharmacology of arachodonic acid metabolites
Elements of chemotherapy
Prerequisites for admission
basic knowledge of biochemistry, physiology and anatomy
Teaching methods
Power point lessons in presence.
Teaching Resources
Materiale iconografico in formato digitale fornito dal docente via internet tramite il sito Ariel.
Clementi, Fumagalli - Farmacologia Generale e Molecolare; UTET - Quarta edizione
Clark, Finkel, Rey, Whalen -Le basi della farmacologia; Zanichelli - Seconda edizione italiana
Golan et al., Principi di Farmacologia; Casa Editrice Ambrosiana
Rossi, Cuomo, Riccardi - Farmacologia: principi di base e applicazioni terapeutiche - II edizione, Edizioni Minerva Medica.
Clementi, Fumagalli - Farmacologia Generale e Molecolare; UTET - Quarta edizione
Clark, Finkel, Rey, Whalen -Le basi della farmacologia; Zanichelli - Seconda edizione italiana
Golan et al., Principi di Farmacologia; Casa Editrice Ambrosiana
Rossi, Cuomo, Riccardi - Farmacologia: principi di base e applicazioni terapeutiche - II edizione, Edizioni Minerva Medica.
Assessment methods and Criteria
The exam is aimed to evaluate the Learning of the students. The exam consists of 40 multiple choices questions to be completed in 2 hours time. Each correct answer has a value of 0.75 points. the exam is passed with a minimum of 18/30.
General pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 32 hours
Professor:
Sironi Luigi
Molecular and Cellular Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 32 hours
Professor:
Sacerdote Paola Giuseppina
Educational website(s)
Professor(s)
Reception:
Monday, 14.30-16.30; Thursday, 14.30-15.30
via Vanvitelli 32