Principles of Formulation of Natural Products and Cosmetics
A.Y. 2025/2026
Learning objectives
The course is aimed at supplying theoretical and practical fundamentals for the preparation of conventional dosage forms. Tools will be provided to understand the relationships between physico-chemical properties of the active ingredients, route of administration, design of the dosage form and bioavailability. In the laboratory practicals, basics for the formulation of immediate-release dosage forms will be acquired, and selected preparations for oral as well as topical administration will be approached.
Expected learning outcomes
Through this course the student will acquire theoretical and practical fundamentals of formulation and preparation of immediate-release dosage forms. Also, she/he will understand key relationships between physico-chemical properties of the active ingredients, route of administration, design of the dosage form and bioavailability. Attending laboratory practicals, she/he will have the opportunity to consolidate and apply concepts learned during the lectures, and skills in the preparation of immediate-release dosage forms for oral and topical administration are expected to be developed.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
Course syllabus
- Introduction
- Dosage forms. Definition and classification. Administration routes
- Biopharmaceutics: LADME processes, pharmacokinetic parameters, bioavailability, factors affecting oral bioavailability, Noyes -Whitney's law, absolute and relative bioavailability, bioequivalence
- The skin barrier. Principles and mechanism of percutaneous absorption. Percutaneous absorption assessment.
- Powders: properties and characterization
- Dispersions and solutions
- Unit operations: grinding, mixing, granulation, drying, tableting, coating
- Stability of dosage forms
- Dosage forms. Definition and classification. Administration routes
- Biopharmaceutics: LADME processes, pharmacokinetic parameters, bioavailability, factors affecting oral bioavailability, Noyes -Whitney's law, absolute and relative bioavailability, bioequivalence
- The skin barrier. Principles and mechanism of percutaneous absorption. Percutaneous absorption assessment.
- Powders: properties and characterization
- Dispersions and solutions
- Unit operations: grinding, mixing, granulation, drying, tableting, coating
- Stability of dosage forms
Prerequisites for admission
Knowledge of fundamentals of mathematics and information science, in addition to basic principles of chemistry and biology.
Teaching methods
Classes and single-bench laboratory practicals with compulsory attendance.
Teaching Resources
- Class slides available on myAriel website
- Handout of laboratory practicals
- Recommended textbooks (P. Caliceti, Tecnologia farmaceutica, Casa Editrice Ambrosiana - Zanichelli, 2025; M.E. Aulton, K.M.G. Taylor, Tecnologie farmaceutiche, Edra, 2015; P. Minghetti, Legislazione farmaceutica, Casa Editrice Ambrosiana - Zanichelli, 2021)
- Handout of laboratory practicals
- Recommended textbooks (P. Caliceti, Tecnologia farmaceutica, Casa Editrice Ambrosiana - Zanichelli, 2025; M.E. Aulton, K.M.G. Taylor, Tecnologie farmaceutiche, Edra, 2015; P. Minghetti, Legislazione farmaceutica, Casa Editrice Ambrosiana - Zanichelli, 2021)
Assessment methods and Criteria
The final examination consists in a written test on the program covered during classes and practicals, including open- and close-ended questions. The time granted is approximately 60 min. The outcome is communicated within three days in the course of a dedicated session, during which the corrected test is available for viewing, and any students' doubts can be clarified.
CHIM/09 - PHARMACEUTICAL AND TECHNOLOGICAL APPLICATIONS OF CHEMISTRY - University credits: 6
Single bench laboratory practical: 16 hours
Lessons: 40 hours
Lessons: 40 hours
Professors:
Maroni Alessandra, Moutaharrik Saliha
Shifts:
Professor:
Maroni Alessandra
Turno 1
Professor:
Maroni AlessandraTurno 2
Professor:
Moutaharrik SalihaProfessor(s)
Reception:
By appointment
Dipartimento di Scienze Farmaceutiche, Sezione di Tecnlogia e Legislazione Farmaceutiche "M.E. Sangalli", Via G. Colombo 71