Fermentation biotechnology
A.A. 2018/2019
Obiettivi formativi
The course aims to study the strategies employed for the setting-up and management of biotechnological processes for industrial production.The course aims to study the strategies employed for the setting-up and management of biotechnological processes for industrial production.
Risultati apprendimento attesi
"Students will develop the capabilities for setting-up and
manage an industrial fermentation process using microbial
cells. Different tools (strain improvement, metabolic flux
analysis and engineering, statistical analyses, downstream
processing) will be given to the students in order to meet the
demand of high productive and efficient bioprocesses. Several
industrial examples will be showed and critically discussed.Students will develop the capabilities for setting-up and manage
an industrial fermentation process using microbial cells. Different
tools (strain improvement, metabolic flux analysis and
engineering, statistical analyses, downstream processing) will be
given to the students in order to meet the demand of high
productive and efficient bioprocesses. Several industrial examples
will be showed and critically discussed."
manage an industrial fermentation process using microbial
cells. Different tools (strain improvement, metabolic flux
analysis and engineering, statistical analyses, downstream
processing) will be given to the students in order to meet the
demand of high productive and efficient bioprocesses. Several
industrial examples will be showed and critically discussed.Students will develop the capabilities for setting-up and manage
an industrial fermentation process using microbial cells. Different
tools (strain improvement, metabolic flux analysis and
engineering, statistical analyses, downstream processing) will be
given to the students in order to meet the demand of high
productive and efficient bioprocesses. Several industrial examples
will be showed and critically discussed."
Periodo: Primo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Primo semestre
Industrial Bioprocesses Development
Programma
Industrial Bioprocesses Development, - D. Romano (4 CFU) Introduction to bioprocesses: bioreactor design, fermentation techniques (batch, fed batch, continuous), scale-up and scale down approaches, downstream processing, experimental design applied to industrial fermentations. Industrial examples: production of aminoacids (glutamic acid, lysine), organic acids (citric, lactic), solvents, biofuels (ethanol, butanol), flavours (vanilline), antibiotics; production of recombinant proteins in prokaryotes. New generation of bioprocesses: biomaterials (polyamide, polylactic-acid, bacterial cellulose, polyhydroxyalkanoates), fermentation of gaseous substrates (CO2, CH4)
Informazioni sul programma
The examination consists in an interview about the "industrial bioprocesses development" module, and a written test on the "improvement of bioprocesses in yeast" module. The score will be a weighted mean based on the credits of the two modules of the course. Other detailed information will be given during the lessons
Propedeuticità
Info non disponibile
Prerequisiti
- Microbial physiology: biosynthetic pathways of primary metabolism, microbial life cycles. - Basic concepts of enzymatic catalysis and molecular biology- Organic chemistry (reactions of carboxylic acids, ketones, aldehydes, amines)
Materiale di riferimento
Slides of the lessons will be available for students on the "Ariel" platform. Books: Industrial Biotechnology-Products and Processes. 2017 Wiley-VCH Verlag GmbH & Co. Print ISBN: 978-3-527-34181-8
Improvement of bioprocesses in yeast
Programma
Strategies to improve the metabolic performance of yeast cells and production process: metabolic flux balance analysis; recombinant technology in yeast, regulation of carbon source metabolism in yeasts. Strategies to redirect existent metabolic pathways improving industrial processes. Strategies to utilize alternative carbon sources for biofuels production. Strategies to increase stress tolerance for industrial processes. Strategies to introduce new pathways for production of new compounds.
Informazioni sul programma
The examination consists in an interview about the "industrial bioprocesses development" module, and a written test on the "improvement of bioprocesses in yeast" module. The score will be a weighted mean based on the credits of the two modules of the course. Other detailed information will be given during the lessons
Propedeuticità
Info non disponibile
Prerequisiti
Microbial physiology: microbial growthpathways of primary metabolismBiochemistry:basic concepts of enzymatic catalysis and regulation of enzyme activityBasic concepts of molecular biology
Materiale di riferimento
Slides and the list of scientific articles will be available during the course.
Moduli o unità didattiche
Improvement of bioprocesses in yeast
CHIM/11 - CHIMICA E BIOTECNOLOGIA DELLE FERMENTAZIONI - CFU: 3
Lezioni: 24 ore
Docente:
Compagno Concetta Maria
Industrial Bioprocesses Development
CHIM/11 - CHIMICA E BIOTECNOLOGIA DELLE FERMENTAZIONI - CFU: 4
Lezioni: 32 ore
Docente:
Romano Diego
Docente/i
Ricevimento:
lunedì 14.30-16.30
via Mangiagalli 25, terzo piano
Ricevimento:
su appuntamento dopo contatto via mail