Methods in pharmacology and toxicology

A.Y. 2018/2019
6
Max ECTS
48
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The course aims at introducing students to the main pharmacological and toxicological methodologies used to test drugs and biologicals in the cardiometabolic field.
Expected learning outcomes
Undefined
Course syllabus and organization

Single session

Course syllabus
PROGRAM
-Regulation and guidelines for the use animal models in experimental research.
-Regulation and guidelines for clinical and genetic studies.
-Study of cardiovascular and immunometabolic diseases.
-Animal models for the study of obesity and metabolic diseases.
-Animal models for the study of atherosclerosis.
-Platelet aggregation and models for the study of arterial thrombosis.
-Experimental approaches for the study of angiogenesis.
-Immune and autoimmune diseases.
-Use of cytofluorimetry techniques for the study of leukocyte population
-Investigation of oxidative stress in the heart.
-Imaging procedures in vascular biology.
-Imaging procedures in metabolic disorders and obesity.
-Clinical Studies
-Pharmacogenetics
-Biotechnological drugs
-From gene identification to target therapies
-Tests for mutagenesis
-Tests for cancerogenesis
-Reproduction toxicity
-Drug toxicity
-Pharmacovigilance


REFERENCE MATERIAL
The slides of the course are available on the Ariel platform.
Suggested books:
Tossicologia molecolare e cellulare. Paoletti et al , UTET
Tossicologia. Helmut Greim, Zanichelli
Elementi di Tossicologia. Casarett and Doull, Publishing House Ambrosiana
Farmacologia: Principi di base e applicazioni terapeutiche. Rossi, Cuomo and Riccardi, Minerva Medica Edition


PREREQUISITES AND EXAMINATION PROCEDURES
Good knowledge of anatomy, cell biology, biochemistry
and general pharmacology are required. Also a good understanding of English. The course frequency is strongly recommended. Ad interim tests will be organized during the course.
The final test examination is written and focuses on the topics discussed in the course.

TEACHING METHODS
Lessons


LANGUAGE OF INSTRUCTION
Italian


RECOMMENDED PREREQUISITES
Part of the material provided is in English


WEB pages
Ariel e http://www.ccdbiol.unimi.it/
BIO/14 - PHARMACOLOGY - University credits: 6
Lessons: 48 hours
Professor(s)