Pathology
A.Y. 2019/2020
Learning objectives
We will study causes and mechanisms of disease. To this end, we will examine the molecular, cellular and functional effects due to the occurrence of pathogenic events (such as genetic alterations, activation of cellular oncogenes). We will study cell damage, death, adaptation, and the systemic and local reaction to tissue damage, with an in depth analysis of the inflammatory reaction.
Expected learning outcomes
The student will acquire the knowledge tools to understand the fundamental causes of disease mechanisms, with dual focus on general aspects and on molecular mechanisms. She/he will learn the molecular, cellular and functional aspects at the basis of altered cellular states which lead to disease, including cancer.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
Course syllabus
The cellular damage:
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation:
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases:
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology :
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology:
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
The cellular damage:
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation:
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases:
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology :
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology:
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
The cellular damage:
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation:
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases:
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology :
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology:
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation:
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases:
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology :
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology:
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
The cellular damage:
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation:
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases:
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology :
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology:
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
The cellular damage:
Cellular death: necrosis, apoptosis, intermediary forms of cellular death (necroptosis, autophagy, etc.). Molecular circuits and genetic bases of the various programs of cellular death and importance in various pathological trials.
Adaptation and cellular aging: molecular bases of the senescence cellular .The aging of uni- and multi-cellular organisms.
Inflammation:
Acute and chronic inflammation: cellular and molecular bases. Inflammation and cancer: the role of the microbiota.
Genetic Diseases:
Generalities. Technologies for the study of the genetic illnesses in the post-genomic era. Molecular bases of some representative genetic illnesses (mono - and poly-genetics). Genome editing (CRISPR/Cas9).
Molecular Oncology :
Nature of the tumors and characteristics of the neoplastic growth. Concept of tumor progression. Oncogenic circuits and oncosoppressors. Staminal tumor cells. New concepts in the molecular therapy of the tumors.
Physiopathology:
Environment and nutriotional diseases
Cardiovascular apparatus: heart attack and myocardial ischemia. Atherosclerosis
Overview on the physiopathology of other systems
Prerequisites for admission
Propedeuticità consigliate]:
Genetica, Biochimica, Biologia Molecolare, Fisiologia generale.
Genetica, Biochimica, Biologia Molecolare, Fisiologia generale.
Teaching methods
Traditional, lectures with power point slides.
Attendance is strongly suggested
http://users.unimi.it/minucci/didattica.htm
Attendance is strongly suggested
http://users.unimi.it/minucci/didattica.htm
Teaching Resources
Suggested textbooks:
- Pontieri: Patologia e Fisiopatologia Generale (Vol 1) Ed. PICCIN.
- Altucci et al: Patologia Generale (Vol 1). Ed. IDELSON-GNOCCHI.
- Pontieri: Patologia e Fisiopatologia Generale (Vol 1) Ed. PICCIN.
- Altucci et al: Patologia Generale (Vol 1). Ed. IDELSON-GNOCCHI.
Assessment methods and Criteria
Written test, duration 90 minutes. During the course, students attending regularly will have the possibility to perform an "in itinere" written test. Results will be e-mailed to the students, and they will have the possibility to discuss the evaluation.
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 6
Lessons: 48 hours
Professor:
Minucci Saverio
Shifts:
-
Professor:
Minucci SaverioProfessor(s)