Environmental Toxicology
A.Y. 2020/2021
Learning objectives
The course aims: i) to provide the basis for a correct characterization of the adverse effects of xenobiotics, by defining methods and approaches managed in the toxicological evaluation; ii) to characterize the molecular mechanisms underlying the adverse effects, the organ toxicity and the toxic effects of different classes of chemicals, such as pesticides, metals, solvents, natural toxins.
Expected learning outcomes
At the end of the course the student will have knowledge on the different approaches and methods to evaluate environmental contaminants from a toxicological point of view and will develop competences for their correct evaluation
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
The lessons will take place remotely synchronously using MicrosoftTeams platform. If requested by the students, insights will be planned in presence.
Course syllabus
The following topics will be addressed:
- elements of general toxicology
- cell damage mechanisms and repair systems
- genotoxicity and chemical carcinogenesis
- immunotoxicology
- developmental and reproductive toxicity
- hepatotoxicity
- nephrotoxicity
- neurotoxicity
- pulmonary toxicity
- skin toxicity
- ocular toxicity
- endocrine disruptors
- metal toxicity
- toxicity of solvents
- toxicity of pesticides
- food toxicology
- toxicology of biotechnological products
- natural toxins
- ionizing radiations
- risk assessment
- elements of general toxicology
- cell damage mechanisms and repair systems
- genotoxicity and chemical carcinogenesis
- immunotoxicology
- developmental and reproductive toxicity
- hepatotoxicity
- nephrotoxicity
- neurotoxicity
- pulmonary toxicity
- skin toxicity
- ocular toxicity
- endocrine disruptors
- metal toxicity
- toxicity of solvents
- toxicity of pesticides
- food toxicology
- toxicology of biotechnological products
- natural toxins
- ionizing radiations
- risk assessment
Prerequisites for admission
Toxicology is a multidisciplinary science that uses the knowledge and techniques of most branches of biology, biochemistry, physiology and medicine, chemistry, math and physics. A minimum knowledge of these subjects is necessary to be able to follow the course.
Teaching methods
Frontal lessons and question time for further information
Teaching Resources
- Casarett & Doull. Elementi di tossicologia di John B. III Watkins, Curtis D. Klaassen. Ed. CEA
- Galli, Corsini, Marinovich. Tossicologia, Ed. Piccin
- Galli, Corsini, Marinovich. Tossicologia, Ed. Piccin
Assessment methods and Criteria
Assessment of learning: oral exam, in which the learning of the topics covered, the ability of synthesis and connection will be evaluated. The student's ability to frame the problems of toxicological evaluation in the perspective of assessing human and environmental safety will be evaluated. The student will have to demonstrate that he/she has understood the key concepts and the main operational tools that characterize the safety assessment of xenobiotics. The exam will last up to 30 minutes and up to five questions will be asked about the program. The answer to each question will be assigned a score from 0-30 and the weighted average of the scores obtained in the single questions will represent the final mark.
Professor(s)
Reception:
By telephone or e-mail appointment
Dip. di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Via Balzaretti 9, Milano