Pharmacology and pharmacotherapy

A.Y. 2020/2021
10
Max ECTS
80
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The main objective of the course will be to provide the pharmacological bases of therapeutics and the pharmacological profiles of the most used drugs. For each topic we will provide a description of the physio pathologic aspects of the disease, mechanisms of drug action, posology and side effects of the main drugs used for the cure of the disease.
The course will also discuss novel therapeutic interventions based on the advancement of basic research with respect to pathophysiological knowledge as well as biochemical and molecular alterations of specific disorders.
Another key object of the Course will be to discuss the main problems associated with drug-drug interactions, as well as the mechanisms that may be responsible for side effects and tolerability, as well as those that will contribute to the therapeutic response to a given drug.
Expected learning outcomes
The student must demonstrate to possess adequate knowledge of pharmacology and pharmacotherapy of the disorders presented during the course, as well as to have the ability to comprehend problems associated with pharmacological treatments. Moreover, the student must be able to apply basic knowledge to deal with pharmacological issues related to treatment. Last, he/she should be able to show abilities in exposing and communicating his/her knowledge.
Course syllabus and organization

Linea AL

Responsible
Lesson period
Second semester
The lessons will be partly live online and partly registered on Microsoft Teams. In both cases, the registration of the lessons will be made available.
The final examination will be online using Microsoft teams.
All the infomration on the course will be posted on ARIEL.
Course syllabus
Drugs acting at synaptic and neuroeffector junctional sites
Drugs acting on the central nervous system
Drug addiction and drug abuse
Drugs affecting renal function and electrolyte metabolism
Antihypertensive drugs
Drug used for the treatment of acute coronary syndromes
Antiarrhythmic drugs
Drugs for the treatment of dyslipidemias
Drugs affecting gastrointestinal function
Drugs acting on the blood and blood-forming organs
Pharmacogenetics and pharmacogenomics
Prerequisites for admission
The student must have knowledge in physiology, biochemistry, and molecular pharmacology (drug interaction with targets).
Teaching methods
Lectures
Teaching Resources
"The pharmacological basis of therapeutics" Goodman & Gilman Macmillan Publishing Co., Inc: New York. Il testo è on line ed è sempre aggiornato.
"FARMACOLOGIA Principi di base e applicazioni terapeutiche" Rossi, Cuomo, Riccardi - Minerva Medica
"Farmacologia Generale e Clinica" Katzung B.G. - edizione italiana
Assessment methods and Criteria
The final evaluation consists in an oral examination, lasting approximately 30-40 minutes. The student must answer to questions on the drugs discussed during the course, being able to comprehend problems associated with pharmacological treatments and using appropriate language.
BIO/14 - PHARMACOLOGY - University credits: 10
Lessons: 80 hours
Professor: Calabresi Laura

Linea MZ

Responsible
Lesson period
Second semester
Since the course will be in the second semester, it should be given in person as usual with teaching materials available on ARIEL. If the emergency will continue, the course will be given in synchronous through ZOOM with some meetings in person. The exam will be, as usual, an oral test that, alternatively, will tale place through ZOOM.
Course syllabus
Drugs acting on the central and peripheral nervous system:
Etiology of psychiatric disorders
Schizophrenia and antipsychotic drugs;
Mood disorders and antidepressant drugs;
Bipolar disorder: antimanic drugs and mood stabilizers;
Anxiolytic drugs and sedative drugs;
Dopaminergic system and drug used for Parkinson disease;
Epilepsy and anticonvulsant drugs;
Alzheimer disorder and its pharmacological treatment;
Drug abuse
General and local anesthetic drugs;
Narcotic and opioid analgesics

Drugs for the Cardiovascular System and Blood Components:
Pharmacological regulation of blood pressure
Drugs for Dyslipidemia
Anti-anginal and anti-ischemic drugs
Insulins and hypoglycemic drugs
Weight control medications
Heart failure medications
Anticoagulants and platelet aggregation inhibitors
Pharmacotherapy of inflammation
Therapy of anemias

Other classes of drugs:
Drugs for the Gastrointestinal system: Antiulcer and Antiemetics.
Hypothalamic-pituitary-adrenal axis: glucocorticoids and mineralocorticoids;
Hypothalamic-pituitary-gonadal axis: estrogens and progestins.
Gout therapy and anti-inflammatory drugs

Insights and applied pharmacology:
Microbiota and drugs
Nutraceuticals in the prevention of dyslipidemias
Nutraceuticals in the prevention of the metabolic syndrome
Pharmacogenetics & Pharmacogenomics
Drugs in pregnancy
Natural products and central nervous system
Pharmacology of food control
Variability in response to drug treatment: towards personalized medicine
Study models for psychiatric diseases
Prerequisites for admission
The student must possess the basic principles governing the interaction of drugs with their biological targets, integrating notions of general pharmacology, biochemistry and pharmaceutical chemistry. Moreover, the student must have basic notions of physiology and physiopathology.
Teaching methods
The teaching will be delivered through lectures
Teaching Resources
"The pharmacological basis of therapeutics"
Goodman & Gilman Macmillan Publishing Co., Inc: New York. XIII Edition ( English).
Assessment methods and Criteria
The exam of Pharmacology and Pharmacotherapy course consists of an oral test lasting about 30-40 minutes. The student must be able to answer questions related to the topics covered during the course demonstrating a good command of the knowledge learned by clearly exposing them as well as showing reasoning skills in integrating the information received during the course.
BIO/14 - PHARMACOLOGY - University credits: 10
Lessons: 80 hours
Professor: Riva Marco Andrea
Professor(s)
Reception:
appointment request through email