Applied Toxicology in Animal Production
A.Y. 2021/2022
Learning objectives
The aim of the course is to give to the student the knowledge of xenobiotics with toxic activity for the animals, with particular reference to the mechanisms of action. In addition, basic toxicological risk assessment concepts for food of animal origin will be provided.
Expected learning outcomes
At the end of the course the student must be able to describe the toxicological characteristics of the main xenobiotics that can enter the livestock production cycle
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
Second semester
More specific information on the delivery modes of training activities for a.y. 2021-22 will be provided over the coming months, based on the evolution of the public health situation
Course syllabus
Introduction: chapters and purposes of toxicology, history of toxicology, classification and source of poisons (6 h)
Toxicocinetics exposure, absorption, distribution, metabolism, excretion (4 h)
Toxicodynamics and mechanisms of action of toxic substances (2 h)
Exogenous and endogenous factors that affect the toxicity of poisons (2 h)
Lethal dose (DL 50) - Maximum Tolerated Dose in large animals (2 h)
Experimental models and meaning of "Subacute Toxicity" and "Chronic Toxicity" (2 h)
Specific toxicity: mutagenicity, carcinogenicity, teratogenesis, reproduction effects (2 h)
Determination of threshold values (DGA, ADI, TDI, TWI etc.) (2 h)
Determination of the tolerance level - MRL (2 h)
Characterization management and communicationof of the risk (2 h)
Pesticides (8 h)
Poisoning by metals or minerals (6 h)
Poisonings from toxic plants (2 h)
Poisoning from mycotoxins (4 h)
Poisoning from non-proteic nitrogen compounds (2 h)
Toxicocinetics exposure, absorption, distribution, metabolism, excretion (4 h)
Toxicodynamics and mechanisms of action of toxic substances (2 h)
Exogenous and endogenous factors that affect the toxicity of poisons (2 h)
Lethal dose (DL 50) - Maximum Tolerated Dose in large animals (2 h)
Experimental models and meaning of "Subacute Toxicity" and "Chronic Toxicity" (2 h)
Specific toxicity: mutagenicity, carcinogenicity, teratogenesis, reproduction effects (2 h)
Determination of threshold values (DGA, ADI, TDI, TWI etc.) (2 h)
Determination of the tolerance level - MRL (2 h)
Characterization management and communicationof of the risk (2 h)
Pesticides (8 h)
Poisoning by metals or minerals (6 h)
Poisonings from toxic plants (2 h)
Poisoning from mycotoxins (4 h)
Poisoning from non-proteic nitrogen compounds (2 h)
Prerequisites for admission
Knowledge of chemistry and biochemistry are required.
Teaching methods
The course includes lectures, held in the classroom.
Teaching Resources
The material used in the classroom for explanations will be present on the UNIMI Ariel portal.
Books
Mengozzi-Soldani (2010) Tossicologia Veterinaria, Idelson-Gnocchi
GUPTA R.C. (2018) Veterinary toxicology 3rd Ed- edited by Elsevier Academic Press.
Books
Mengozzi-Soldani (2010) Tossicologia Veterinaria, Idelson-Gnocchi
GUPTA R.C. (2018) Veterinary toxicology 3rd Ed- edited by Elsevier Academic Press.
Assessment methods and Criteria
Verification of learning is carried out through a written examination with open questions concerning special general toxicology.
VET/07 - VETERINARY PHARMACOLOGY AND TOXICOLOGY - University credits: 6
Lessons: 48 hours
Professor:
Villa Roberto Edoardo
Educational website(s)
Professor(s)
Reception:
By appointment from Monday to Friday
Dep. DIVAS Lodi