Biomarkers: from Identification to Exploitation
A.Y. 2022/2023
Learning objectives
The objective of the course is to provide the students with the skills to understand how to identify a new biomarker taking advantage of omics strategy and population studies. Processes to validate the detection strategy for a biomarker, the statistical analysis to correlate the biomarker with a clinical outcome, and market exploitation will be discussed.
Expected learning outcomes
At the end of the course, students will have the knowledge to design strategies to discover and validate novel biomarkers.
Lesson period: First semester
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
Prerequisites for admission
Teaching Unit: Bioanalytical methods in drug and biomarkers discovery
None
Teaching Unit: Pharmacological Validation of biomarkers
None
Teaching Unit: Molecular endocrinology and endocrine biomarkers
Knowledge of anatomy, physiology and biochemistry
None
Teaching Unit: Pharmacological Validation of biomarkers
None
Teaching Unit: Molecular endocrinology and endocrine biomarkers
Knowledge of anatomy, physiology and biochemistry
Assessment methods and Criteria
The exam consists in an oral exam during which the level of knowledge of the concepts described during the course will be assessed and the critical capacity of the candidate will be assessed regarding the consistency, validity and any needs still to be satisfied in the context of biomarkers in pharmacology. The mark will be expressed in thirtieths.
Module: Bioanalytical methods and pharmacological validation of biomarkers
Course syllabus
Unit A: Bioanalytical methods in drug and biomarkers discovery
Statistical methods of data processing
Analytical instrumental techniques in the determination of biomarkers
Bioanalytical approaches in the study of biomarkers
Applications in vascular pathologies and cancer
Unit B: Pharmacological Validation of biomarkers
Frontal lessons:
Definition of Biomarkers
Biomarkers in pharmacology and drug discovery
Biomarkers validation
Biomarkers in cardiovascular diseases
Biomarkers in neurodegenerative diseases
Biomarkers in neuropsychopharmacology
ESEPS: discussion of scientific papers and clinical trials. The students are divided in working groups for the first part and then all the groups will share their conclusion for a collegial discussion. The teacher will actively participate to the work of each single the groups and to the final debate.
Statistical methods of data processing
Analytical instrumental techniques in the determination of biomarkers
Bioanalytical approaches in the study of biomarkers
Applications in vascular pathologies and cancer
Unit B: Pharmacological Validation of biomarkers
Frontal lessons:
Definition of Biomarkers
Biomarkers in pharmacology and drug discovery
Biomarkers validation
Biomarkers in cardiovascular diseases
Biomarkers in neurodegenerative diseases
Biomarkers in neuropsychopharmacology
ESEPS: discussion of scientific papers and clinical trials. The students are divided in working groups for the first part and then all the groups will share their conclusion for a collegial discussion. The teacher will actively participate to the work of each single the groups and to the final debate.
Teaching methods
Active Lectures. Frontal lessons: frequency not mandatory but suggested. ESEPS: frequency is mandatory.
Teaching Resources
All the slides presented by the teacher and the scientific article will be available on Ariel website
Module: Molecular endocrinology and endocrine biomarkers
Course syllabus
General concepts of endocrinology
Biosynthesis, secretion and transport of peptide hormones
Biosynthesis, secretion and transport of steroid hormones
Mechanism of action of peptide hormones
Mechanism of action of steroid hormones
Hypothalamus, pituitary and neuroendocrine physiopathology
Physiopathology of parathyroid glands
Physiopathology of thyroid gland
Endocrine pancreas and diabetes mellitus
Physiopathology of the reproduction
Physiopathology of adrenal glands
Biosynthesis, secretion and transport of peptide hormones
Biosynthesis, secretion and transport of steroid hormones
Mechanism of action of peptide hormones
Mechanism of action of steroid hormones
Hypothalamus, pituitary and neuroendocrine physiopathology
Physiopathology of parathyroid glands
Physiopathology of thyroid gland
Endocrine pancreas and diabetes mellitus
Physiopathology of the reproduction
Physiopathology of adrenal glands
Teaching methods
Active Lectures. Frequency is not mandatory even if it is strongly suggested.
Teaching Resources
Williams Textbook of Endocrinology, Shlomo Melmed et al, Elsevier
Greenspan's Basic and Clinical Endocrinology, David Gardner, McGraw-Hill
Principles of Endocrinology and hormone action, Antonino Belfiore & Derek, Springer
All slides presented by the teacher will be available on Ariel website
LeRoith, Springer
Greenspan's Basic and Clinical Endocrinology, David Gardner, McGraw-Hill
Principles of Endocrinology and hormone action, Antonino Belfiore & Derek, Springer
All slides presented by the teacher will be available on Ariel website
LeRoith, Springer
Module: Bioanalytical methods and pharmacological validation of biomarkers
BIO/14 - PHARMACOLOGY
CHIM/08 - PHARMACEUTICAL CHEMISTRY
CHIM/08 - PHARMACEUTICAL CHEMISTRY
Single bench laboratory practical: 16 hours
Lessons: 40 hours
Lessons: 40 hours
Professors:
Calabrese Francesca, D'Amato Alfonsina
Module: Molecular endocrinology and endocrine biomarkers
MED/13 - ENDOCRINOLOGY AND METABOLISM - University credits: 4
Lessons: 32 hours
Professor:
Giatti Silvia
Professor(s)