Inorganic Analysis of Substances Having Pharmaceutical Interest and Qualitative Analysis Laboratory
A.Y. 2023/2024
Learning objectives
Two didactic units composes the course: lectures (Inorganic Analysis of Substances having Pharmaceutical Interest) and individual laboratory training (Qualitative Analysis Laboratory).
The main topics of the lectures are the in-depth analysis of the preparatory courses knowledge (General and Inorganic Chemistry, and Stoichiometry and Analytical Chemistry) applied on the qualitative analysis and the learning of laboratory safety rules, basic techniques of the practical experimental chemistry and the analytical procedures to apply during the laboratory experiences, focused on the identification of the inorganic compounds of medicinal and toxicological relevance.
Concerning the experimental practices, the students will improve the technical ability to identify the inorganic substances prescribed by Italian and European Pharmacopoeias.
The main topics of the lectures are the in-depth analysis of the preparatory courses knowledge (General and Inorganic Chemistry, and Stoichiometry and Analytical Chemistry) applied on the qualitative analysis and the learning of laboratory safety rules, basic techniques of the practical experimental chemistry and the analytical procedures to apply during the laboratory experiences, focused on the identification of the inorganic compounds of medicinal and toxicological relevance.
Concerning the experimental practices, the students will improve the technical ability to identify the inorganic substances prescribed by Italian and European Pharmacopoeias.
Expected learning outcomes
By the lectures, the students will improve their knowledge concerning the theoretical and practical aspects related to the qualitative analysis, which they will apply during the individual experimental practices.
By the laboratory experiences (mandatory), the students will acquire expertize to perform the qualitative analysis of inorganic compounds.
By the laboratory experiences (mandatory), the students will acquire expertize to perform the qualitative analysis of inorganic compounds.
Lesson period: Activity scheduled over several sessions (see Course syllabus and organization section for more detailed information).
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Linea 1
Responsible
Lesson period
First semester
Course syllabus
Program of the lectures:
- Introduction to the inorganic qualitative analysis.
- Safety guidelines in chemistry laboratory and hazard prevention.
- Basic laboratory procedures.
- Theoretical aspects of the dissolution and precipitation processes.
- Salt hydrolysis: acid/base properties of anions, cations and salts.
- Analysis of anions.
- Analysis of cations (analysis by precipitation of six analytical groups).
- Identification methods for unknown inorganic compounds listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
- Limit tests: principles reported in F.U.
- Introduction to the laboratory simulator (LabSim).
- Introduction to the pharmaceutical, toxicological and biochemical properties of the inorganic compounds analyzed during the laboratory work.
Program of the practical laboratory experiences:
- Introduction to basic techniques in laboratory practice.
- Anion recognition assays.
- Cation recognition assays (periodic analysis by precipitation of six analytical groups).
- Identification of unknown inorganic substances listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
- Introduction to the inorganic qualitative analysis.
- Safety guidelines in chemistry laboratory and hazard prevention.
- Basic laboratory procedures.
- Theoretical aspects of the dissolution and precipitation processes.
- Salt hydrolysis: acid/base properties of anions, cations and salts.
- Analysis of anions.
- Analysis of cations (analysis by precipitation of six analytical groups).
- Identification methods for unknown inorganic compounds listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
- Limit tests: principles reported in F.U.
- Introduction to the laboratory simulator (LabSim).
- Introduction to the pharmaceutical, toxicological and biochemical properties of the inorganic compounds analyzed during the laboratory work.
Program of the practical laboratory experiences:
- Introduction to basic techniques in laboratory practice.
- Anion recognition assays.
- Cation recognition assays (periodic analysis by precipitation of six analytical groups).
- Identification of unknown inorganic substances listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
Prerequisites for admission
The course takes place in the first semester of the second year. The students are expected to have a basic Inorganic Chemistry knowledge.
Teaching methods
The course includes both lectures (Inorganic Analysis of Substances having Pharmaceutical Interest unit) and practical laboratory experiences (Qualitative Analysis Laboratory unit).
The unit of Inorganic Analysis of Substances Having Pharmaceutical Interest (5 CFU) consists in lectures preparing the students to experimental laboratory training, which take place at the same time and, for this reason, the attendance is recommended.
The unit of Qualitative Analysis Laboratory (2 CFU) consists in eight individual obligatory laboratory sessions. To support this teaching activity, the student can access to the LabSim simulator (https://www.ddl.unimi.it/labsim/index_en.htm), which is a tool for innovative teaching specially developed to offer a complete immersive experience based on the virtual reality technology. Here, he can deepen his knowledge of the practical aspects and can practice before the sessions in the real laboratory.
The unit of Inorganic Analysis of Substances Having Pharmaceutical Interest (5 CFU) consists in lectures preparing the students to experimental laboratory training, which take place at the same time and, for this reason, the attendance is recommended.
The unit of Qualitative Analysis Laboratory (2 CFU) consists in eight individual obligatory laboratory sessions. To support this teaching activity, the student can access to the LabSim simulator (https://www.ddl.unimi.it/labsim/index_en.htm), which is a tool for innovative teaching specially developed to offer a complete immersive experience based on the virtual reality technology. Here, he can deepen his knowledge of the practical aspects and can practice before the sessions in the real laboratory.
Teaching Resources
Recommended books:
- A. Araneo, Chimica Analitica Qualitativa, Casa Editrice Ambrosiana, Milano.
- G. Charlot, Analisi Chimica Qualitativa, Piccin Editore, Padova.
- G. Svela, Vogel's Qualitative Inorganic Analysis, Edizioni Logman, Harlow.
Reference books:
- F. Savelli, O. Bruno, Analisi Chimico Farmaceutica, Piccin Editore, Padova.
- Farmacopea Ufficiale della Repubblica Italiana.
- Farmacopea Europea.
Supporting material:
Avaialble in digital format by download from Ariel site.
- A. Araneo, Chimica Analitica Qualitativa, Casa Editrice Ambrosiana, Milano.
- G. Charlot, Analisi Chimica Qualitativa, Piccin Editore, Padova.
- G. Svela, Vogel's Qualitative Inorganic Analysis, Edizioni Logman, Harlow.
Reference books:
- F. Savelli, O. Bruno, Analisi Chimico Farmaceutica, Piccin Editore, Padova.
- Farmacopea Ufficiale della Repubblica Italiana.
- Farmacopea Europea.
Supporting material:
Avaialble in digital format by download from Ariel site.
Assessment methods and Criteria
The final exam consists of a written test of 13 questions that must be completed in 90 minutes. The overall evaluation is scored in thirtieths and, in particular, each question can be evaluated with a maximum of 2/30 for a total amount of 26/30. The remaining 4/30 derive from the evaluation of the laboratory activity (Qualitative Analysis Laboratory unit), which consists in the analysis of 4 unknown inorganic substances (three water-soluble and one water-insoluble) reported in the European Pharmacopeia. Each substance correctly identified is assigned a score of 1/30 for a total of 4/30 of the laboratory evaluation. The so acquired score is communicated anonymously via the Ariel platform before the first session useful for taking the written test. The final score of the exam is communicated by e-mail via the SIFA/UniMia platform within one week from the date of taking the written test, unless otherwise communicated. Examples of the written exam are available on the Ariel platform of the Course.
Inorganic Analysis of Substances having Pharmaceutical Interest
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 5
Lessons: 40 hours
Professor:
Pedretti Alessandro
Qualitative Analysis Laboratory
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 2
Single bench laboratory practical: 32 hours
Professors:
Meneghetti Fiorella, Pedretti Alessandro
Shifts:
Turno 1
Professor:
Pedretti AlessandroTurno 2
Professor:
Meneghetti FiorellaLinea 2
Responsible
Lesson period
Second semester
Course syllabus
Program of the lectures:
- Introduction to the inorganic qualitative analysis.
- Safety guidelines in chemistry laboratory and hazard prevention.
- Basic laboratory procedures.
- Theoretical aspects of the dissolution and precipitation processes.
- Salt hydrolysis: acid/base properties of anions, cations and salts.
- Analysis of anions.
- Analysis of cations (analysis by precipitation of six analytical groups).
- Identification methods for unknown inorganic compounds listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
- Limit tests: principles reported in F.U.
- Introduction to the pharmaceutical, toxicological and biochemical properties of the inorganic compounds analyzed during the laboratory experiences.
Program of the practical laboratory experiences:
- Introduction to basic techniques in laboratory practice.
- Anion identification assays.
- Cation identification assays (periodic analysis by precipitation of six analytical groups).
- Identification of unknown inorganic substances listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
- Introduction to the inorganic qualitative analysis.
- Safety guidelines in chemistry laboratory and hazard prevention.
- Basic laboratory procedures.
- Theoretical aspects of the dissolution and precipitation processes.
- Salt hydrolysis: acid/base properties of anions, cations and salts.
- Analysis of anions.
- Analysis of cations (analysis by precipitation of six analytical groups).
- Identification methods for unknown inorganic compounds listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
- Limit tests: principles reported in F.U.
- Introduction to the pharmaceutical, toxicological and biochemical properties of the inorganic compounds analyzed during the laboratory experiences.
Program of the practical laboratory experiences:
- Introduction to basic techniques in laboratory practice.
- Anion identification assays.
- Cation identification assays (periodic analysis by precipitation of six analytical groups).
- Identification of unknown inorganic substances listed in the European Pharmacopoeia (water-soluble and water-insoluble substances).
Prerequisites for admission
The course takes place during the second term of the second year. Knowledges concerning General and Inorganic Chemistry, Stoichiometry and Analytical Chemistry (preparatory courses) are required.
Teaching methods
The course includes both lectures (Power Point presentations) and practical laboratory experiences.
The lectures (5 CFU) prepare the students to experimental laboratory training, which take place at the same time, therefore the attendance at lectures is recommended.
The Qualitative Analysis Laboratory (2 CFU) consists in eight individual mandatory laboratory sessions.
The lectures (5 CFU) prepare the students to experimental laboratory training, which take place at the same time, therefore the attendance at lectures is recommended.
The Qualitative Analysis Laboratory (2 CFU) consists in eight individual mandatory laboratory sessions.
Teaching Resources
Supporting material, concerning the lecture topics, is available in digital format (course site, Ariel), to deepen through:
Recommended books
- A. Araneo, Chimica Analitica Qualitativa, Casa Editrice Ambrosiana, Milano.
- G. Charlot, Analisi Chimica Qualitativa, Piccin Editore, Padova.
- G. Svela, Vogel's Qualitative Inorganic Analysis, Edizioni Logman, Harlow.
Reference books:
- F. Savelli, O. Bruno, Analisi Chimico Farmaceutica, Piccin Editore, Padova.
- Farmacopea Ufficiale della Repubblica Italiana.
- Farmacopea Europea.
Recommended books
- A. Araneo, Chimica Analitica Qualitativa, Casa Editrice Ambrosiana, Milano.
- G. Charlot, Analisi Chimica Qualitativa, Piccin Editore, Padova.
- G. Svela, Vogel's Qualitative Inorganic Analysis, Edizioni Logman, Harlow.
Reference books:
- F. Savelli, O. Bruno, Analisi Chimico Farmaceutica, Piccin Editore, Padova.
- Farmacopea Ufficiale della Repubblica Italiana.
- Farmacopea Europea.
Assessment methods and Criteria
The final examination consists of a written test with 5 open questions that must be completed in 120 minutes. The overall score of the answers is 26/30. The remaining 4/30 derive from the evaluation of the laboratory activity (Qualitative Analysis Laboratory).
Inorganic Analysis of Substances having Pharmaceutical Interest
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 5
Lessons: 40 hours
Professor:
Gelain Arianna
Qualitative Analysis Laboratory
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 2
Single bench laboratory practical: 32 hours
Professor:
Gelain Arianna
Shifts:
Turno 3
Professor:
Gelain AriannaEducational website(s)
Professor(s)
Reception:
Every day by appointment
Deparment of Pharmaceutical Sciences - Medicinal Chemistry