Effect of Pollutants On Developmental Anatomy and Physiology
A.Y. 2025/2026
Learning objectives
At the end of the course, the student will be able to:
· Understand how pollutants interfere with anatomical and physiological development.
· Identify the critical stages of development that are vulnerable to toxic agents.
· Analyze the molecular and cellular mechanisms underlying placental function.
· Understand how pollutants interfere with anatomical and physiological development.
· Identify the critical stages of development that are vulnerable to toxic agents.
· Analyze the molecular and cellular mechanisms underlying placental function.
Expected learning outcomes
Understand the ways in which environmental pollutants affect human development. Recognize and describe critical windows of vulnerability during embryonic and fetal development, linking them to the main types of exposure to xenobiotics. Interpret the molecular and cellular mechanisms involved in the transmission of toxic agents from mother to fetus, with particular attention to the role of the placental barrier. Apply appropriate scientific terminology in describing congenital malformations, physiological dysfunctions, and developmental alterations caused by pollutants. Critically analyze scientific data on the environmental impact on developing organisms and formulate hypotheses regarding public health risks.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
Second semester
Course syllabus
Anatomy
· Basic concepts: embryonic and postnatal development
· Critical periods: windows of vulnerability
· Types of pollutants: metals, pesticides, endocrine disruptors
Anatomical Effects of Pollutants
· Congenital malformations
· Intrauterine growth retardation
· Alterations in brain and skeletal development
Physiological and Functional Effects
· Endocrine and metabolic dysfunctions
· Alterations of the immune system
· Impact on the central and peripheral nervous system
Molecular and Cellular Mechanisms
· Mechanisms underlying maternal-fetal communication
· Fetal absorption of xenobiotics mediated by the blood-placenta barrier
· Basic concepts: embryonic and postnatal development
· Critical periods: windows of vulnerability
· Types of pollutants: metals, pesticides, endocrine disruptors
Anatomical Effects of Pollutants
· Congenital malformations
· Intrauterine growth retardation
· Alterations in brain and skeletal development
Physiological and Functional Effects
· Endocrine and metabolic dysfunctions
· Alterations of the immune system
· Impact on the central and peripheral nervous system
Molecular and Cellular Mechanisms
· Mechanisms underlying maternal-fetal communication
· Fetal absorption of xenobiotics mediated by the blood-placenta barrier
Prerequisites for admission
Have passed the exam in Anatomy, Physiology, and Toxicology.
Teaching methods
Course slides available on Ariel and review articles on the topic that will be covered during the course.
Teaching Resources
Slides and review, as well as recommended readings during the course.
Assessment methods and Criteria
Oral examination on the complete program covered
BIO/09 - PHYSIOLOGY - University credits: 3
BIO/16 - HUMAN ANATOMY - University credits: 3
BIO/16 - HUMAN ANATOMY - University credits: 3
Lessons: 48 hours
Professors:
Borsello Tiziana, Saponaro Andrea Cosimo
Professor(s)
Reception:
by appointment
via Balzaretti 9, or on MS Teams