Physiopathology, introduction in biotechnologies diagnostic and therapy

A.Y. 2019/2020
Overall hours
MED/06 MED/09 MED/13 MED/15 MED/18 MED/26
Learning objectives
The training course has the following aims:
- Comprehension of the main physiological systems and their related pathophysiology
- Comprehension of the principles of diagnostic and therapy in liquids and solids tumors
Expected learning outcomes
The course aims to provide students with the basic knowledge of the major human diseases and the processes that cause them, in order to provide the necessary background for understanding the role of the biotechnology tools employed in diagnostics and therapy of these alterations. To this end, the course is structured in a series of lectures regarding the pathophysiology of the main systems complemented by lectures on the possible biotechnological approaches related to the diagnostics and treatment of the analyzed diseases.
Course syllabus and organization

Single session

Lesson period
First semester
Prerequisites for admission
Students must have fulfilled all the prerequisite requirements indicated in the study plan: Biochemistry and Fundamentals of Human Biochemistry, General Pathology and Immunology, Human phyisiology.
Assessment methods and Criteria
Verification of learning takes place through a written test. Reference materials are not allowed during the learning verification. The test results are sent electronically by the President of the Integrated Course of Clinical Sciences. The final mark represents the weighted average of the individual modules and will be expressed in 30/30.
Medical physiopathology
Course syllabus
Pathophysiology of the Nervous System and neurodegenerative diseases
Pathophysiology of the Cardiovascular System:
The heart as a pump, Heart failure
Ischemic heart disease
The Hypertension
The vascular occlusive disease
Pathophysiology of the Respiratory System:
The acute respiratory failure
The chronic respiratory failure
Pathophysiology of the Endocrine:
Role of biotechnology in the management of endocrine tumors (oncogenes and tumor suppressor);
Premature ovarian failure: menopausal age prediction and tools for fertility preservation;
Pathophysiology of GnRH neuron: molecular diagnostics and fertility biotech drugs;
Sensitivity problems and promiscuity hormonal action
Pathophysiology of kidney: Acute renal failure and chronic
Pathophysiology of the liver: acute hepatitis, chronic hepatitis, cirrhosis. NAFLD, NASH.
Pathophysiology of the Hematopoietic System:
Iron metabolism and related conditions
Teaching methods
Teaching takes place through lectures with slide projections.
Teaching Resources
Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.
Principles of diagnostic and biotechnological therapy
Course syllabus
Principles of diagnostics and therapy in hematology:
Hematopoiesis and its diagnostics
New methods to study tumor transformation in hematology
Haemostasis and Thrombosis
The hematopoietic stem cell
Myeloproliferative diseases
Lymphoproliferative diseases
Plasma cells disorders
Concepts of hematopoietic stem cell transplantation
Minimal residual disease in onco-hematology: methods and applications;
Molecular therapy in hematology: new drugs and monoclonal antibodies;
Outline of methodology in clinical research

Principles of diagnostics and therapy in oncology:
Principles of tumor biology: mechanisms of neoplastic transformation
Cancer stem cells
New drugs and monoclonal antibodies
Teaching methods
Teaching takes place through lectures with slide projections.
Teaching Resources
Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.
Medical physiopathology
MED/09 - INTERNAL MEDICINE - University credits: 0
MED/13 - ENDOCRINOLOGY AND METABOLISM - University credits: 0
MED/15 - BLOOD DISEASES - University credits: 0
Informal teaching: 16 hours
Lessons: 32 hours
Principles of diagnostic and biotechnological therapy
MED/06 - MEDICAL ONCOLOGY - University credits: 0
MED/18 - GENERAL SURGERY - University credits: 0
MED/26 - NEUROLOGY - University credits: 0
Informal teaching: 8 hours
Lessons: 28 hours
Friday 14-15 (appointment requested)
IRCCS Istituto Auxologico Italiano - Ospedale San Luca (5°piano) - Piazzale Brescia 20 - 20149 Milano
appointment to be agreed by e-mail