Physiopathology, introduction in biotechnologies diagnostic and therapy

A.Y. 2020/2021
Overall hours
MED/06 MED/09 MED/13 MED/15 MED/18 MED/26
Learning objectives
The training course has the following aims:
- Comprehension of the main physiological systems and their related pathophysiology
- Comprehension of the principles of diagnostic and therapy in liquids and solids tumors
Expected learning outcomes
The course aims to provide students with the basic knowledge of the major human diseases and the processes that cause them, in order to provide the necessary background for understanding the role of the biotechnology tools employed in diagnostics and therapy of these alterations. To this end, the course is structured in a series of lectures regarding the pathophysiology of the main systems complemented by lectures on the possible biotechnological approaches related to the diagnostics and treatment of the analyzed diseases.
Course syllabus and organization

Single session

Lesson period
First semester
Any notice regarding updates or also related to the evolution of the regulations imposed by Covid-19 will be published on the degree course Ariel website and on Ariel website of the individual courses as well as communicated by the teaching secretariat.
The educational activity of the course will be provided as frontal teaching and distance teaching (in synchronous modality). The presence in the classroom will be possible in shifts in compliance with anti-covid regulations.
The methods and criteria for participating in the lessons in attendance, which require a reservation with a special app, will be published on the Ariel pages of the teaching and/or by the teaching secretary of the course.
In case of a new suspension of frontal lessons, all students will be asked to switch to synchronous distance learning. Each hour of the lesson will be divided into 45" formal teaching followed by 15" discussion / interaction / question time.
All lectures will be recorded and available to students on dedicated platforms (e.g. Ariel, TEAMS, etc.).

The program and reference material will not be changed. The latter will be made available on dedicated platforms (e.g. Ariel, TEAMS, etc.)

Unless otherwise specified, the exams will be organized in the classroom and according to the reported learning methods. If the student will not be able to reach the exam center due to problems with COVID, other modalities may be considered (this applies only to exams scheduled until 31 December - 2020)
Prerequisites for admission
Students must have fulfilled all the prerequisite requirements indicated in the study plan: Biochemistry and Fundamentals of Human Biochemistry, General Pathology and Immunology, Human phyisiology.
Assessment methods and Criteria
Verification of learning takes place through a written test. Reference materials are not allowed during the learning verification. The test results are sent electronically by the President of the Integrated Course of Clinical Sciences. The final mark represents the weighted average of the individual modules and will be expressed in 30/30.
Medical physiopathology
Course syllabus
Pathophysiology of the Nervous System and neurodegenerative diseases
Pathophysiology of the Cardiovascular System:
The heart as a pump, Heart failure
Ischemic heart disease
The Hypertension
The vascular occlusive disease
Pathophysiology of the Respiratory System:
The acute respiratory failure
The chronic respiratory failure
Pathophysiology of the Endocrine:
Role of biotechnology in the management of endocrine tumors (oncogenes and tumor suppressor);
Premature ovarian failure: menopausal age prediction and tools for fertility preservation;
Pathophysiology of GnRH neuron: molecular diagnostics and fertility biotech drugs;
Sensitivity problems and promiscuity hormonal action
Pathophysiology of kidney: Acute renal failure and chronic
Pathophysiology of the liver: acute hepatitis, chronic hepatitis, cirrhosis. NAFLD, NASH.
Pathophysiology of the Hematopoietic System:
Iron metabolism and related conditions
Teaching methods
Teaching takes place through lectures with slide projections.
Teaching Resources
Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.
Principles of diagnostic and biotechnological therapy
Course syllabus
Principles of diagnostics and therapy in hematology:
Hematopoiesis and its diagnostics
New methods to study tumor transformation in hematology
Haemostasis and Thrombosis
The hematopoietic stem cell
Myeloproliferative diseases
Lymphoproliferative diseases
Plasma cells disorders
Concepts of hematopoietic stem cell transplantation
Minimal residual disease in onco-hematology: methods and applications;
Molecular therapy in hematology: new drugs and monoclonal antibodies;
Outline of methodology in clinical research

Principles of diagnostics and therapy in oncology:
Principles of tumor biology: mechanisms of neoplastic transformation
Cancer stem cells
New drugs and monoclonal antibodies
Teaching methods
Teaching takes place through lectures with slide projections.
Teaching Resources
Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.
Medical physiopathology
Informal teaching: 16 hours
Lessons: 32 hours
Principles of diagnostic and biotechnological therapy
Informal teaching: 8 hours
Lessons: 28 hours
Friday 14-15 (appointment requested)
IRCCS Istituto Auxologico Italiano - Ospedale San Luca (5°piano) - Piazzale Brescia 20 - 20149 Milano
appointment to be agreed by e-mail