Qualitative analysis of inorganic drugs

A.Y. 2020/2021
6
Max ECTS
72
Overall hours
SSD
CHIM/08
Language
Italian
Learning objectives
The course, which includes practical training, allows the student to approach the practice of chemistry for the first time, particularly of analytical chemistry. Its main purpose is the learning of correct, accurate and conscious "modus operandi" in the elementary analytical chemistry procedures. To achieve this goal, the fundamental principles of qualitative chemical analysis are illustrated in the lessons and implemented in subsequent experimental laboratory, with particular regard to inorganic substances of pharmaceutical and toxicological interest. Furthermore, the student has the opportunity to perform many recognition procedures described in the Italian and the European pharmacopoeias.
Expected learning outcomes
At the end of the course, the student will acquire the basics of the analytical methods applied in the analysis of inorganic substances of pharmaceutical interest. The student will be able to choose the analytical method suitable for the solution of a analytical problem and will be also capable to apply the basic techniques for the analysis of an unknown substance. More specifically, the student, starting from a sample of inorganic drugs, will characterize the chemical composition indicating, at the end of the analytic procedure, the brute formula of the analyzed substance. Furthermore, the student will acquire the basic notions of the pharmacological and / or toxicological properties of inorganic substances of pharmaceutical interest.
During the final examination, the students will demonstrate to comprehend the proposed questions and they will be able to process the knowledge acquired during the lectures and the practical training.
Course syllabus and organization

Linea AK

Responsible
Lesson period
First semester
Teaching methods
The lessons will be held through the Microsoft Teams platform and can be followed both in synchronous, according to the scheduled time, and asynchronously because they are recorded through the same platform. The exercises will be held for 1/3 (16h) in the presence in the educational laboratory suitably equipped for the COVID emergency and for the remaining 2/3 (32h) in the virtual laboratory, through the use of videos and tutorials. If it is not possible to carry out the practical exercises (1/3), these will also be carried out through virtual exercises.

Program and reference material
The program and the reference material of the lectures will not change. All educational support material will always be made available through the Ariel platform.

Learning assessment procedures and assessment criteria
If the situation allows it, the exam will take place in written form, according to the procedures described in the section "Exam procedures". Alternatively, the "Exam.net" platform, already widely used in the second semester 19/20, will be used to carry out the exam in written form remotely.
Course syllabus
The course focuses on the following topics: (i) safety rules in a chemical laboratory; prevention of laboratory risks; (ii) general information on operations and laboratory equipment; (iii) introduction to inorganic qualitative chemical analysis; (iv) theoretical aspects of solubilization, extraction and precipitation processes; (v) oxidation-reduction equilibria in relation to pH and precipitation; (vi) formation of complexes and their stability as a function of pH. Dissolution of precipitates by complexation; (vii) analysis od cations by classical systematic analysis with subdivision into the six analytical groups; (viii) analysis of anions; (ix) guide to the identification of water-soluble inorganic substances of the EP; (x) guide to the identification of water-insoluble inorganic substances; (xi) biochemical, chemical-pharmaceutical and toxicological properties of the inorganic substances under analysis; (xii) limit tests.
Prerequisites for admission
To successfully follow the lessons of this course, the student must have basic knowledge of general and inorganic chemistry.
Teaching methods
Frontal lessons and individual practical training.
Teaching Resources
The powerpoint presentations used for the lessons are available to students on UniMi's Ariel platform.
For further information, the following texts are recommended:
- A. Araneo, Chimica analitica qualitativa, Casa Editrice Ambrosiana.
- F.P. Treadwell, Chimica Analitica, Analisi qualitativa, Casa Editrice Vallardi.
- G. Svehla, Vogel'sQualitative Inorganic Analysis, John Wiley & Sons, New York.
- G. Charlot, Analisi Chimica qualitativa, Piccin Editore, Padova.
- Farmacopea Ufficiale della Repubblica Italiana X e XI Ed.
- Farmacopea Europea IV Ed.
Assessment methods and Criteria
The exam consists of two tests: practical and written ones. In the practical test, the student has to recognize 4 single inorganic salts and two inorganic salts in a mixture, totaling a maximum of 6/30 points. The written test is based on specific questions (both theoretical and applicative) in which the student can score the remaining 24/30 points.
The evaluation of the test will take into account the student's ability to know how to apply the main methods of qualitative analysis in order to identify inorganic active ingredients reported in the Pharmacopoeia and the ability to independently manage the related analytical problems.
LABORATORY OF QUALITATIVE ANALYSIS OF INORGANIC DRUGS
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 3
Single bench laboratory practical: 48 hours
Professor: Grazioso Giovanni
QUALITATIVE ANALYSIS OF INORGANIC DRUGS
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 3
Lessons: 24 hours
Professor: Grazioso Giovanni

Linea LZ

Responsible
Lesson period
First semester
The lessons will be delivered through the Microsoft Teams platform and can be followed in synchrony according to the scheduled time and asynchronously because they are recorded through the same platform.

The program and the reference material of the lesson will not change.

The exam consists of two tests: practical and oral ones. In the practical test, the student has to recognize 2 single inorganic salts totaling a maximum of 2 points.
The oral test will take place using the Microsoft Teams platform and is based on specific questions (both theoretical and applicative) in which the student can score the remaining 28/30 points. The duration will be about 40 minutes.
Course syllabus
The course focuses on the following topics: (i) safety rules in a chemical laboratory; prevention of laboratory risks; (ii) general information on operations and laboratory equipment; (iii) introduction to inorganic qualitative chemical analysis; (iv) theoretical aspects of solubilization, extraction and precipitation processes; (v) oxidation-reduction equilibria in relation to pH and precipitation; (vi) formation of complexes and their stability as a function of pH. Dissolution of precipitates by complexation; (vii) analysis od cations by classical systematic analysis with subdivision into the six analytical groups; (viii) analysis of anions; (ix) guide to the identification of water-soluble inorganic substances of the EP; (x) guide to the identification of water-insoluble inorganic substances; (xi) biochemical, chemical-pharmaceutical and toxicological properties of the inorganic substances under analysis; (xii) limit tests.
Prerequisites for admission
To successfully follow the lessons of this course, the student must have basic knowledge of general and inorganic chemistry.
Teaching methods
Lessons and individual laboratory training.
Teaching Resources
The powerpoint presentations used for the lessons are available on UniMi's Ariel platform.
For further information, the following texts are recommended:
- A. Araneo, Chimica analitica qualitativa, Casa Editrice Ambrosiana.
- F.P. Treadwell, Chimica Analitica, Analisi qualitativa, Casa Editrice Vallardi.
- G. Svehla, Vogel'sQualitative Inorganic Analysis, John Wiley & Sons, New York.
- G. Charlot, Analisi Chimica qualitativa, Piccin Editore, Padova.
- Farmacopea Ufficiale della Repubblica Italiana X e XI Ed.
- Farmacopea Europea IV Ed.
Assessment methods and Criteria
The exam consists of two tests: practical and written ones. In the practical test, the student has to recognize 4 single inorganic salts and two inorganic salts in a mixture, totaling a maximum of 6/30 points. The written test is based on specific questions (both theoretical and applicative) in which the student can score the remaining 24/30 points.
The evaluation of the test will take into account the student's ability to know how to apply the main methods of qualitative analysis in order to identify inorganic active ingredients reported in the Pharmacopoeia and the ability to independently manage the related analytical problems.
LABORATORY OF QUALITATIVE ANALYSIS OF INORGANIC DRUGS
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 3
Single bench laboratory practical: 48 hours
Professor: Grazioso Giovanni
QUALITATIVE ANALYSIS OF INORGANIC DRUGS
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 3
Lessons: 24 hours
Professor: Bolchi Cristiano
Professor(s)
Reception:
Friday 10.30 -12.30, fixing an appointment by email
Office 2015 - Lab. 2053 - Via Mangiagalli 25