Biology and genetics

A.Y. 2021/2022
6
Max ECTS
60
Overall hours
SSD
BIO/12 BIO/13 MED/03
Language
Italian
Learning objectives
- The student must learn notions on the structure and function of the main macromolecules and cellular differentiation as well as the molecular basis of the expression of genetic information, its regulation and the transmission mobility of hereditary characters;
- It must also acquire chemical, biological and biochemical knowledge at the base of life sciences, including fundamental chemical reactions, biochemical processes and the cellular and sub-cellular structures assigned to them, the modes of transmission and expression of genetic information and fundamental dynamics of the processes that regulate the life of living organisms.
Expected learning outcomes
Acquiring chemical, biological and biochemical knowledge at the base of life sciences. Acquisition of essential concepts to be able to follow with success lessons of the following years.
Course syllabus and organization

Single session

More specific information on the delivery modes of training activities for academic year 2021/22 will be provided over the coming months, based on the evolution of the public health situation.
Prerequisites for admission
Not required
Assessment methods and Criteria
La modalità di esame consiste in una prova scritta con quesiti a risposta multipla (1 sola risposta corretta) e domande aperte. Ogni domanda vale da 1 a 1.5 punti a seconda del modulo, tranne le risposte aperte che possono valere fino a 2 punti per un totale di 30 punti (ed eventuale lode). Per ogni sessione di appello verranno previsti almeno 2 appelli riguardanti tutti i moduli. Verrà effettuata una prova in itinere alla fine di ogni modulo che permetterà agli studenti di valutare la loro preparazione in previsione degli appelli d'esame. I risultati verranno comunicati immediatamente al termine della prova in quanto la correzione del compito è immediata. Se uno studente in una prova di appello d'esame supera con un voto di 18/30 o superiore un modulo ma non gli altri, il voto rimarrà valido per tutto l'anno accademico ma potrà essere verbalizzato solo quando lo studente supererà anche gli altri moduli. Il voto finale sarà la media matematica dei voti presi nei singoli moduli.
Clinical biochemistry and molecular biology
Course syllabus
· Clinical Biochemistry: introduction, aims, definitions
· Levels of intervention of the laboratory. Types of tests, blood sample, urine sample, other types of biological sample
· Concept of total variability; Biological variability and factors that influence the preparation of the subject / patient. Pre-analytical variability: sampling, storage, transport delivery, acceptability criteria of a biological sample. Analytical variability, types of errors, reliability of an assay method, post-analytical variability: reporting
· Reference values, analytical goals and the critical difference
· Diagnostic logic: clinical sensitivity and specificity, predictive values
In-depth study of some topics chosen by the teacher (The role of the Laboratory in myocardial infarction, diabetes, liver diseases, dyslipidemias ...)
Teaching methods
The teaching will be delivered in the form of lectures. The course program, slides and review material will be provided to students by the teacher at the start of the course on the Ariel platform.
Teaching Resources
Chiara Donati, Massimo Stefani, Niccolò Taddei "Biologia e Genetica" ZANICHELLI · Solomon, Berg, Martin "Elementi di biologia" EDISES · Curtis, Barnes, Schnek, Massarini "Le basi della biologia" ZANICHELLI · Sadava, Hillis, Heller, Berenbaum "Elementi di biologia e genetica" ZANICHELLI · Campbell, Reece "Biologia e genetica" PEARSON · Chieffi, Dolfini, Malcovati, Pierantoni, Tenchini: "Biologia e Genetica" EDISES · Barbieri L., Strocchi E., Lezioni di Patologia generale, II edizione digitale, Rimini, Polo Scientifco Didattico di Rimini, 2012 · Federici G., Medicina di laboratorio, Milano, MC GRAW HILL, 2008 · Gaw. A. Biochimica Clinica, Milano, Elsevier Masson, 2007 · Lepore M.A., Principali tecniche di biologia molecolare clinica, Roma, ARACNE EDITRICE, 2009
Experimental biology
Course syllabus
Characteristics of living organisms: cell theory; cell study methods; prokaryotic cells; eukaryotic cells; hierarchical organization in biology; evolution of organisms.
· Characteristics of biological marcomolecules: lipids, nucleic acids and proteins.
· Structure and organization of the eukaryotic cell: cell compartmentalization; cell organelles; ribosomes; cytoskeleton; junctions; matrix.
· Structure and function of biological membranes: fluid mosaic model; transport through the membrane.
· Cellular communication: communication mode between cells.
· Cell cycle and its regulation: cycle phases; control system.
· DNA replication: central dogma of biology; Meselson and Stahl experiment; molecular replication; DNA damage repair.
Transcription: various types of RNA; synthesis of RNA; maturation of messenger RNAs.
· Translation and genetic code: genetic code and its properties; protein synthesis mechanism; post-synthetic fate of proteins.
· The genome of eukaryotes: structure of chromatin; the nucleosome; gene structure (intron-exons); control of gene expression.
· Virus: structure; bacterial, animal and plant viruses; cell-virus interactions
Teaching methods
The teaching will be delivered in the form of lectures. The course program, slides and review material will be provided to students by the teacher at the start of the course on the Ariel platform.
Teaching Resources
· Chiara Donati, Massimo Stefani, Niccolò Taddei "Biologia e Genetica" ZANICHELLI
· Solomon, Berg, Martin "Elementi di biologia" EDISES
· Curtis, Barnes, Schnek, Massarini "Le basi della biologia" ZANICHELLI
· Sadava, Hillis, Heller, Berenbaum "Elementi di biologia e genetica" ZANICHELLI
· Campbell, Reece "Biologia e genetica" PEARSON
· Chieffi, Dolfini, Malcovati, Pierantoni, Tenchini: "Biologia e Genetica" EDISES
· Barbieri L., Strocchi E., Lezioni di Patologia generale, II edizione digitale, Rimini, Polo Scientifco Didattico di Rimini, 2012
· Federici G., Medicina di laboratorio, Milano, MC GRAW HILL, 2008
· Gaw. A. Biochimica Clinica, Milano, Elsevier Masson, 2007
· Lepore M.A., Principali tecniche di biologia molecolare clinica, Roma, ARACNE EDITRICE, 2009
Medical genetics
Course syllabus
· Molecular basis of heredity: genes, chromosomes; somatic and germ cells; karyotype; mitosis and meiosis; gametogenesis and fertilization; sex determination; inactivation of the X chromosome.
- Numerical and structural anomalies of the karyotype. · Mendelian genetics: gene, allele, locus; Mendel's laws; genotype and phenotype; interactions between alleles; multiple allelism (ABO).
- Classification of gene mutations · Characters and Inheritance: genealogical trees; monogenic genetic diseases: autosomal dominant, autosomal recessive, sex-linked inheritance, mitochondrial inheritance. Examples of genetic diseases: isolated and syndromic deafness. Multifactorial diseases. · Pre- and postnatal genetic tests.
Teaching methods
The teaching will be delivered in the form of lectures. The course program, slides and review material will be provided to students by the teacher at the start of the course on the Ariel platform.
Teaching Resources
· Chiara Donati, Massimo Stefani, Niccolò Taddei "Biologia e Genetica" ZANICHELLI
· Solomon, Berg, Martin "Elementi di biologia" EDISES
· Curtis, Barnes, Schnek, Massarini "Le basi della biologia" ZANICHELLI
· Sadava, Hillis, Heller, Berenbaum "Elementi di biologia e genetica" ZANICHELLI
· Campbell, Reece "Biologia e genetica" PEARSON
· Chieffi, Dolfini, Malcovati, Pierantoni, Tenchini: "Biologia e Genetica" EDISES
· Barbieri L., Strocchi E., Lezioni di Patologia generale, II edizione digitale, Rimini, Polo Scientifco Didattico di Rimini, 2012
· Federici G., Medicina di laboratorio, Milano, MC GRAW HILL, 2008
· Gaw. A. Biochimica Clinica, Milano, Elsevier Masson, 2007
· Lepore M.A., Principali tecniche di biologia molecolare clinica, Roma, ARACNE EDITRICE, 2009
Clinical biochemistry and molecular biology
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY - University credits: 2
Lessons: 20 hours
Professor: Paroni Rita Clara
Experimental biology
BIO/13 - EXPERIMENTAL BIOLOGY - University credits: 2
Lessons: 20 hours
Medical genetics
MED/03 - MEDICAL GENETICS - University credits: 2
Lessons: 20 hours
Professor: Miozzo Monica Rosa
Educational website(s)
Professor(s)
Reception:
to be scheduled, please email me for additional information
LITA, Via Fratelli Cervi 93, Segrate, MI