Communicable and non-communicable diseases

A.Y. 2021/2022
8
Max ECTS
64
Overall hours
SSD
BIO/19 MED/04
Language
English
Learning objectives
The objective of the course is to provide a specific knowledge and a critical evaluation on the pathological bases for precision medicine interventions. The overall learning objective is thus to provide an updated discussion of selected topics on precision medicine, which is notoriously a present and future important biomedical approach and includes relevant biotechnological aspects. The course includes two modules: Pathological bases for precision medicine interventions and Infectious diseases and drug resistance. In the first module, the following topics will be discussed: general principles of precision medicine, molecular determinants of individual health, precision medicine in oncology (molecular determinants, examples of precision medicine in oncology), precision medicine in cardiovascular and metabolic health, machine learning and artificial intelligence for precision medicine. In the second module, the following topics will be discussed: overview of human-microbe interactions, antimicrobial compounds: mechanism of action and resistance, identifying novel conventional targets for antimicrobial discovery, and non-conventional targets for novel generation of antimicrobial compounds, challenges in novel antimicrobial compound discovery.
Expected learning outcomes
At the end of the course, the students are expected to possess a solid knowledge and understanding on the pathological bases for precision medicine interventions. The acquired skills and competencies will be the tools through which the students will improve their capacity to correlate the different concepts in different areas of precision medicine, applying their skills to the comprehension of complex problems in this field. Moreover, they will be enabled to implement better judgment, communication skills and learning abilities in this complex scientific area, especially in relationship with topics relevant to biotechnology.
Course syllabus and organization

Single session

Responsible
Lesson period
First semester
More specific information on the delivery modes of training activities for academic year 2022/2022 will be provided over the coming months, based on the evolution of the public health situation.
Course syllabus
The course includes two modules: Pathological bases for precision medicine interventions and Infectious diseases and drug resistance.

In the first module, the following topics will be discussed: a) atherosclerotic cardiovascular diseases; b) mendelian randomization analyses; c) metabolic syndrome; d) diabetes; e) genes related to non-alcoholic fatty liver disease; f) neurodegenerative diseases; g) extracellualr vescicles; h) Thyroid.
In the second module, the following topics will be discussed: overview of human-microbe interactions, anti-infective compounds: mechanism of action and resistance, identifying novel conventional targets for antimicrobial discovery, and non-conventional targets for novel generation of antimicrobial compounds, challenges in novel antimicrobial compounds discovery.
Prerequisites for admission
Basic knowledge of anatomy, physiology, and microbiology.
Teaching methods
Active lectures
Teaching Resources
a) Pathological bases for precision medicine interventions (Robbins and Cotran).
b) Selected scientific materials (articles, websites) will be provided.
c) The lesson slides will be available on the Ariel website to the students.
Assessment methods and Criteria
Oral
Infectious diseases and drug resistance
BIO/19 - MICROBIOLOGY
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Lessons: 16 hours
Pathological bases for precision medicine interventions
BIO/19 - MICROBIOLOGY
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Lessons: 48 hours
Professor(s)
Reception:
Upon request
INGM, via Francesco Sforza 35, or DiSFeB, via Balzaretti 9, Milano