Molecular and cellular bases of metabolic and nutritional diseases

A.Y. 2021/2022
Overall hours
BIO/09 MED/04
Learning objectives
The aim of the course is to provide the bases for the understanding of metabolic and nutrition disorders by discussing the molecular and cellular mechanisms behind such human diseases. By the end of the course, students will have an overview of the correlations that exist between molecular/cellular disfunctions and the macroscopic phenotype of the disease. Moreover, students will be able to critically evaluate and discuss the latest scientific literature focused on metabolic and nutrition disorders.
Expected learning outcomes
At the end of the course, students should have acquired a comprehensive view of the interrelations between molecular and cellular malfunctions and the macroscopic phenotype of the disease. Moreover, students should have developed the ability to understand, interpret and critically evaluate the scientific literature in the field e to disseminate the conclusions emerging from such publications.
Course syllabus and organization

Single session

Lesson period
Second semester
Due to the pandemic health condition associated with COVID-19 the course will be taught online both in synchronous and asynchronous using the "Teams" application.
The program and the reference material will not change
The exam will be written either in presence or online; all the information regarding the organization of the exam, as well as any other updates are provided on the Ariel website of the course
The evaluation criteria will not change and are those reported in the syllabus
Course syllabus
Adverse reaction to Foods: food allergy, coeliac disease, food intolerance, and toxic reaction.
Malabsorption Syndromes.
Nutritional disorders: malnutrition (undernutrition and overnutrition).
Metabolic alterations: metabolic syndrome.
Gastrointestinal pathologies: irritable bowel syndrome, Crohn's disease, ulcerative colitis.
Metabolic and nutritional disorders and cardiovascular pathology: atherosclerosis and hypertension.
Metabolic and nutritional disorders and liver pathology: cirrhosis, steatosis.
Metabolic and nutritional disorders and kidney pathology: chronic kidney disease.
Metabolic and nutritional disorders: cancer cachexia
Prerequisites for admission
Students must know basic concepts of general physiology and biochemistry
Teaching methods
Teaching will be based on interactive frontal lectures supported by projected slides. Students will be actively involved into discussions to elaborate the topics covered during the lectures with a critical point of view, in order to improve their independent thinking and communication skills.
Teaching Resources
The course is entirely based on bibliographic material. Lecture slides, scientific research articles and reviews regarding each lecture topics (uploaded on ARIEL)
Assessment methods and Criteria
Students knowledge will be assessed with a written essay composed of 2 open questions on the topics covered during the course. Students will also present and discuss a scientific article in front of their classmates. The overall evaluation of the course will take into account both the written essay and the article presentation. The final mark will be the sum of the written essay (max 27/30) and the article presentation (max 3/30).
If the overall examination appears of excellent level, a "cum Laude" will be added to the final mark.
BIO/09 - PHYSIOLOGY - University credits: 0
Lessons: 48 hours
on request, via email
via G. Celoria, 26 20133 Milano, B tower, 6th floor