Systems and Diseases I

A.Y. 2020/2021
19
Max ECTS
240
Overall hours
SSD
MED/03 MED/08 MED/09 MED/10 MED/11 MED/14 MED/18 MED/24
Language
Italian
Learning objectives
The course of Systems and Diseases I is arranged as a summary point of the knowledge acquired in the first three years and as a starting point for following clinical learning.
The course consists of 2 parts:
· the first part is dedicated to learning signs and symptoms, including references to pathophysiology, and the ability to collect anamnesis and perform physical examination.
· a second part of Systems Pathology, dedicated to the study of the pathogenesis of diseases affecting Respiratory System, Cardiovascular System, Kidney and of Urinary Tracts, and to the anatomopathological study of the aforementioned organs.
In the course of Systems and Diseases I, for each system/apparatus the following general objectives will be pursued: knowledge of the diseases more frequent and/or which have particular relevance in terms of severity, possibility of therapeutic intervention and/or didactic model; definition of the disease, knowledge of main epidemiological data, pathogenic causes and mechanisms; ability to illustrate the nosographic framework, symptoms at onset and status; interpretation of the biochemical data and proper the use of instrumental imaging investigations useful for diagnosis. The anatomic-pathological and/or genetic context will be also discussed for some diseases.
The Systems and Diseases I course therefore aims to provide students with:
· Knowledge of the structure and function of the main organ systems, including molecular/genetic, biochemical and cellular mechanisms for the maintenance of homeostasis
· Knowledge of principles of epidemiology and scientific bases of research methods relevant for health care.
· Knowledge of the pathogenesis and of the anatomopathological basis of main diseases in cardiology, pulmonology, nephrology and urology fields.
· Nosographic, pathogenetic and pathophysiological knowledge of the most relevant diseases of the various organs and / or systems in the context of a unitary and global understanding of human pathology.
· Clinical concepts of diseases of various organs and / and systems and their correlations with symptoms, physical signs and functional alterations, with interpretation of their pathogenetic mechanisms and understanding of their clinical significance.
· Ability to practice preventive medicine by identifying, addressing and supporting strategies for maintaining health and well-being, identifying and treating diseases in early phases when appropriate, and providing advice on lifestyle practices and prevention.
· Guidelines for conducting research in the medical literature, including electronic databases, and criteria for identifying and interpreting updated evidence to optimize patient care
· Support in promoting lifelong learning and independent research of new knowledge and skills in personal areas of reduced learning in respect of patient care and patient well-
Expected learning outcomes
· A responsible understanding of the importance of maintaining health to prevent diseases through the application of learned pathological principles and the application of appropriate clinical pathways
· the ability to understand and to use the basic principles of epidemiology in its practical application
· the ability to adopt the principles learned in health maintenance and disease prevention
· the ability to explain the basic nature of pathological processes from the point of view of causality, epidemiology, natural history and the structural and functional anomalies that ensue
· the ability to recognize and be able to describe the signs and symptoms of the most relevant human diseases and also of the main organ and / or systems failures evaluated in the various lessons of the Course. All that has to be learnt in the context of a unified and global vision of the relationship between signs, symptoms and pathologies
· the skills to recognize the main cardiovascular, respiratory, nephrological and urological diseases, through a correct differential diagnosis or an adequate setting of the diagnostic program with the use of laboratory / functional / radiological examinations and knowledge of the principles of clinical management
· the acquisition of the skills necessary to formulate a clinical question and perform and present an evidence-based review of that selected health topic
· demonstration of a commitment to lifelong learning, self-awareness in areas of personal lack of concepts, independent research of new knowledge and skills in order to provide optimal assistance to our community
· the acquisition of the preparatory knowledge necessary to follow with success the subsequent courses, in particular those of "Semeiotics and pathology of apparatus 2", of "Medical Clinic" and "Clinic and Surgical Therapy"
Single course

This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.

Course syllabus and organization

Linea: Policlinico

Responsible
Lectures will still take place in classrooms, if students can't reach the buildings we might consider alternative ways.
Prerequisites for admission
Propedeutical courses for Systems and Diseases I include: General Pathology and Physiopathology (compulsory), Human Physiology (compulsory).
For the module of Medical Genetics, the basic knowledge presented in the course of Biology and genetics is expected to be assimilated.
Assessment methods and Criteria
At the end of the course, an oral examination is performed; the test is based on an oral question by at least two teachers responsible for different modules (about 15-20 minutes for each teacher).
During the test, the following elements are evaluated: knowledge of the topics presented during the course, ability of critical reasoning on the study carried out; clarity of the oral presentation and the correct use of specialized lexicon. After collective evaluation of the teachers involved in the exam, the mark is expressed in thirtieths.
Medical genetics
Course syllabus
Rare diseases: diffusion, diagnostic difficulties and new approaches (Next Generation Sequencing): Analysis of panels, clinical exome and whole exome. Notes on the evaluation of gene variants
Dysmorphology: study of the main dysmorphic features. Definitions
Genetic risk factors for male infertility: Chromosomal abnormalities (Klinefelter syndrome, Microdeletions of the Y chromosome); Monogenic diseases (CFTR, AR);
Hereditary cardiomyopathies: Molecular approach for the diagnosis of hereditary heart diseases. Genetic basis of hypertrophic cardiomyopathies; Arrhythmogenic cardiomyopathies; Dilated cardiomyopathies and muscular dystrophies; Non-compaction of left ventricle; Cardiac channelopathies (e.g. long QT and Brugada syndromes). Genetic cardiac malformations with exemplary diseases: Down syndrome and s. DiGeorge / deletion 22q11.2); RASopathies (Noonan and related syndromes).
Teaching methods
Frontal lesson
Teaching Resources
Genetics in Medicine", Thompson &Thompson; durante le lezioni e sul sito Ariel, vengono inoltre indicate pubblicazioni (articoli, reviews) di approfondimento. Infine vengono fornite le presentazioni utilizzate durante le lezioni.
Internal medicine
Course syllabus
History taking
General physical examination
Main signs and symptoms
Physical examination of the Thorax, chest and cardiovascular system (Inspection, palpation, percussion, auscultation) - Physical examination of the abdomen and main clinical pictures of the liver, spleen and pancreas (Inspection, palpation, percussion, auscultation) and main diagnostic approach to exams
Teaching methods
Teaching will be delivered through lectures. The teaching material will be available on the Ariel website of the University
Teaching Resources
Harrison's, Principles of Internal Medicine, 21th ed, McGraw-Hill international, (also available as ebook in the digital library of the University of Milano)
Lynn Bickley. Bates' Physical examination and history taking. Lippincott
Respiratory diseases
Course syllabus
1st part:
· Medical Hystory and respiratory physical examination
· Principles of radiological diagnosis
· Principles of respiratory pathophysiology
· Principles of acid base balance
·
2st part:
· Chronic Obstructive Pulmonary Disease (COPD)
· Astma
· Pulmonary tuberculosis and atypical mycobacteriosis
· Cystic Fibrosis in Adults
· Non tuberculous lung infections
· Lung cancer
· Mediastinal tumor
· Tumor of the pleura
· Non tumoral pleural diseases
· Acute and chronic respiratory failure
· Pulmonary Hypertension
· Pulmonary embolism
Teaching methods
Final oral exam: questions on the contents of particular clinical and pathophysiological relevance relating to the topics covered and resolution of clinical cases
The final test results will be communicated to the end of the exam completion to each individual learner
Teaching Resources
Harrison 's principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018)
With specific reference to the chapters dedicated to respiratory pathology
The most updated bibliographic entries relating to the topics will be provided annually, preferentially referring to original articles and / or revisions recently published in high-impact scientific journals
Cardiovascular diseases
Course syllabus
-Cardiovascular risk stratification.
-Ischemic heart disease
-Chest pain management
-Hypertension
-Aortic and mitral valve disease
-Electrocardiography
-Echocardiography
-Heart failure
-Cardiac arrhythmias
-Mio-pericarditis
-Cardiomyopaties
-Congenital heart disease
-Pulmonary hypertension
Teaching methods
Oral lessons (48 hours)
Non-frontal lessons (12 hours)
Practical tutorials
Teaching Resources
Harrison. Principles of Internal Medicine

di Dennis L. Kasper, Anthony S. Fauci, Dan L. Longo
Nephrology
Course syllabus
1st part:
· Notes on renal anatomy and physiology
· Main symptoms related to kidney diseases
· Evaluation of glomerular function
· Evaluation of tubular function
· Evaluation of renal endocrine function
· Pathogenesis of oedema of renal origin
· Water and electrolyte disturbances
· Nephrological syndromes
· glomerular diseases & vasculitides
· Renal genetic diseases (ADPKD)
· Tubulo-interstitial diseases
UTI
nephrolithiasis

2nd part:
· Renal diseases secondary to systemic diseases
diabetes
neoplasia
· Vascular renal diseases
Atherosclerotic
Hypertensive nephropathy/Nephroangio-sclerosis
· AKI: causes and diagnosis
· CKD: complications and progression
· Notes on the substitutive therapies of ESRD
Teaching methods
Teaching will take advantage of:
- Formal lessons with the support of slides and/or videos
- Practice exercises in small groups on clinical cases and/or queries on clinical conditions commonly found in the nephrology field
- Practical excercises on the patients: gathering medical history, physical examination, small interventions (e.g. blood sampling, bladder catheterization)
- Renal ultra-sound evaluation; microscopic examination of urinary sediment and of the renal tissue obtained by renal biopsy
- participation as bystanders in small groups in highly specialized maneuvers (interventions of central venous catheterization, accomplishment of hemodialysis or peritoneal dialysis accesses, renal biopsies)
- visit in small groups to the renal research laboratory
Teaching Resources
Harrison' s principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018)
With specific reference to the chapters dedicated to renal disease
The most up-to-date bibliographical entries on the topics covered will be provided annually, with preferential reference to original articles and/or revisions recently published in high-impact scientific journals
General surgery
Course syllabus
General semiology of the abdomen.
General semiology of diseases of the lower limbs of vascular origin. Arteriosclerosis. Venous thrombosis and venous reflux.
Peritonitis: signs and symptoms. Clinical and instrumental diagnostics.
Clinical and instrumental semiology of intestinal occlusions.
Clinical and instrumental semiotics of the upper G.I. tract
Semiology of the brest
Teaching methods
Teaching will be delivered through lectures. The teaching material will be available on the Ariel website of the University
Teaching Resources
Chirurgia Generale- F. Minni - CEA ed. ISBN : 978-8808320490, Gennaio 2019
Sabiston- Trattato di Chirurgia 20° edizione - EDRA ed.. ISBN : 978-8821446917, Marzo 2019
Pathology
Course syllabus
Introduction to Anatomic Pathology

General principles of histopathology, cytopathology and autopsies.
Ancillary techniques in anatomic pathology (immunohistochemistry, FISH and others molecular techniques)
General principles of diagnostic histopathology (pathological growth: metaplasia, dysplasia; tumor grading, tumor staging; the pathology report; prognostic and predictive markers)


Cardiovascular pathology

Pathology of the vessels: Arteriosclerosis, Atherosclerosis, Aneurysms and Dissection, Vascular Tumors
Heart Failure
Congenital Heart Disease
Ischemic Heart Disease
Valvular Heart Disease
Cardiomyopathies
Pericardial Disease
Cardiac Transplantation

Pathology of the lung and pleura

Congenital Anomalies, Atelectasis (Collapse), Pulmonary Edema
Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage)
Obstructive and Restrictive Lung Diseases
Chronic Diffuse Interstitial (Restrictive) Diseases
Pulmonary Infections
Lung Transplantation
Tumors of the lung
Pleural Effusion
Pleural Tumors
Teaching methods
Lectures
Teaching Resources
Robbins and Cotran. PATHOLOGIC BASIS OF DISEASE (9th Edition)
Urology
Course syllabus
Urological semeiotics
Andrological semeiotics
Haematuria
Kidney tumors
Prostate cancer
Bladder tumors
Testicular tumors
BPH
Urinary incontinence
Genitourinary infections
Urinary lithiasis
Infertility and varicocele
Erectile disfunction
Andrological urgencies
Uro-andrological traumatology
Teaching methods
Teaching will take advantage of:
- Formal lessons with the support of slides and/or videos
- Practical excercises on the patients: gathering medical history, physical examination, small interventions (e.g.urethral calibration, bladder washing, bladder catheterization)
- participation as bystanders in small groups in highly specialized maneuvers (cystoscopies and bladder biopsies, ultrasound and prostate biopsies, urological surgical procedures)
Teaching Resources
- Harrison' s principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018) con specifico riferimento ai capitoli dedicati alla patologia urologica
- Urologia (Francesco Porpiglia e coll.) Edizioni Minerva Medica - 2015
The most up-to-date bibliographical entries on the topics covered will be provided annually, with preferential reference to original articles and/or revisions recently published in high-impact scientific journals
Cardiovascular diseases
MED/11 - CARDIOVASCULAR DISEASES - University credits: 5
Informal teaching: 16 hours
Lessons: 48 hours
General surgery
MED/18 - GENERAL SURGERY - University credits: 1
Lessons: 12 hours
Professor: Ferraresso Mariano
Internal medicine
MED/09 - INTERNAL MEDICINE - University credits: 1
Lessons: 12 hours
Medical genetics
MED/03 - MEDICAL GENETICS - University credits: 1
Lessons: 12 hours
Professor: Miozzo Monica Rosa
Nephrology
MED/14 - NEPHROLOGY - University credits: 4
Informal teaching: 16 hours
Lessons: 36 hours
Professors: Alfieri Carlo Maria, Messa Piergiorgio
Pathology
MED/08 - PATHOLOGY - University credits: 2
Lessons: 24 hours
Respiratory diseases
MED/10 - RESPIRATORY DISEASES - University credits: 4
Informal teaching: 16 hours
Lessons: 36 hours
Urology
MED/24 - UROLOGY - University credits: 1
Lessons: 12 hours

Linea: San Donato

Responsible
Lectures will still take place in classrooms, if students can't reach the buildings we might consider alternative ways.
Prerequisites for admission
Propedeutical courses for Systems and Diseases I include: General Pathology and Physiopathology (compulsory), Human Physiology (compulsory).
For the module of Medical Genetics, the basic knowledge presented in the course of Biology and genetics is expected to be assimilated.
Assessment methods and Criteria
At the end of the course, an oral examination is performed; the test is based on an oral question by at least two teachers responsible for different modules (about 15-20 minutes for each teacher).
During the test, the following elements are evaluated: knowledge of the topics presented during the course, ability of critical reasoning on the study carried out; clarity of the oral presentation and the correct use of specialized lexicon. After collective evaluation of the teachers involved in the exam, the mark is expressed in thirtieths.
Medical genetics
Course syllabus
Rare diseases: diffusion, diagnostic difficulties and new approaches (Next Generation Sequencing): Analysis of panels, clinical exome and whole exome. Notes on the evaluation of gene variants
Dysmorphology: study of the main dysmorphic features. Definitions
Genetic risk factors for male infertility: Chromosomal abnormalities (Klinefelter syndrome, Microdeletions of the Y chromosome); Monogenic diseases (CFTR, AR);
Hereditary cardiomyopathies: Molecular approach for the diagnosis of hereditary heart diseases. Genetic basis of hypertrophic cardiomyopathies; Arrhythmogenic cardiomyopathies; Dilated cardiomyopathies and muscular dystrophies; Non-compaction of left ventricle; Cardiac channelopathies (e.g. long QT and Brugada syndromes). Genetic cardiac malformations with exemplary diseases: Down syndrome and s. DiGeorge / deletion 22q11.2); RASopathies (Noonan and related syndromes).
Teaching methods
Frontal lesson
Teaching Resources
Genetics in Medicine", Thompson &Thompson; durante le lezioni e sul sito Ariel, vengono inoltre indicate pubblicazioni (articoli, reviews) di approfondimento. Infine vengono fornite le presentazioni utilizzate durante le lezioni.
Internal medicine
Course syllabus
History taking
General physical examination
Main signs and symptoms
Physical examination of the Thorax, chest and cardiovascular system (Inspection, palpation, percussion, auscultation) - Physical examination of the abdomen and main clinical pictures of the liver, spleen and pancreas (Inspection, palpation, percussion, auscultation) and main diagnostic approach to exams
Teaching methods
Teaching will be delivered through lectures. The teaching material will be available on the Ariel website of the University
Teaching Resources
Harrison's, Principles of Internal Medicine, 21th ed, McGraw-Hill international, (also available as ebook in the digital library of the University of Milano)
Respiratory diseases
Course syllabus
1st part:
· Medical Hystory and respiratory physical examination
· Principles of radiological diagnosis
· Principles of respiratory pathophysiology
· Principles of acid base balance
·
2st part:
· Chronic Obstructive Pulmonary Disease (COPD)
· Astma
· Pulmonary tuberculosis and atypical mycobacteriosis
· Cystic Fibrosis in Adults
· Non tuberculous lung infections
· Lung cancer
· Mediastinal tumor
· Tumor of the pleura
· Non tumoral pleural diseases
· Acute and chronic respiratory failure
· Pulmonary Hypertension
· Pulmonary embolism
Teaching methods
Final oral exam: questions on the contents of particular clinical and pathophysiological relevance relating to the topics covered and resolution of clinical cases
The final test results will be communicated to the end of the exam completion to each individual learner
Teaching Resources
Harrison 's principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018)
With specific reference to the chapters dedicated to respiratory pathology
The most updated bibliographic entries relating to the topics will be provided annually, preferentially referring to original articles and / or revisions recently published in high-impact scientific journals
Cardiovascular diseases
Course syllabus
-Cardiovascular risk stratification.
-Ischemic heart disease
-Chest pain management
-Hypertension
-Aortic and mitral valve disease
-Electrocardiography
-Echocardiography
-Heart failure
-Cardiac arrhythmias
-Mio-pericarditis
-Cardiomyopaties
-Congenital heart disease
-Pulmonary hypertension
Teaching methods
Oral lessons (48 hours)
Non-frontal lessons (12 hours)
Practical tutorials
Teaching Resources
Harrison. Principles of Internal Medicine

di Dennis L. Kasper, Anthony S. Fauci, Dan L. Longo
Nephrology
Course syllabus
1st part:
· Notes on renal anatomy and physiology
· Main symptoms related to kidney diseases
· Evaluation of glomerular function
· Evaluation of tubular function
· Evaluation of renal endocrine function
· Pathogenesis of oedema of renal origin
· Water and electrolyte disturbances
· Nephrological syndromes
· glomerular diseases & vasculitides
· Renal genetic diseases (ADPKD)
· Tubulo-interstitial diseases
UTI
nephrolithiasis

2nd part:
· Renal diseases secondary to systemic diseases
diabetes
neoplasia
· Vascular renal diseases
Atherosclerotic
Hypertensive nephropathy/Nephroangio-sclerosis
· AKI: causes and diagnosis
· CKD: complications and progression
· Notes on the substitutive therapies of ESRD
Teaching methods
Teaching will take advantage of:
- Formal lessons with the support of slides and/or videos
- Practice exercises in small groups on clinical cases and/or queries on clinical conditions commonly found in the nephrology field
- Practical excercises on the patients: gathering medical history, physical examination, small interventions (e.g. blood sampling, bladder catheterization)
- Renal ultra-sound evaluation; microscopic examination of urinary sediment and of the renal tissue obtained by renal biopsy
- participation as bystanders in small groups in highly specialized maneuvers (interventions of central venous catheterization, accomplishment of hemodialysis or peritoneal dialysis accesses, renal biopsies)
- visit in small groups to the renal research laboratory
Teaching Resources
Harrison' s principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018)
With specific reference to the chapters dedicated to renal disease
The most up-to-date bibliographical entries on the topics covered will be provided annually, with preferential reference to original articles and/or revisions recently published in high-impact scientific journals
General surgery
Course syllabus
General semiology of the abdomen.
General semiology of diseases of the lower limbs of vascular origin. Arteriosclerosis. Venous thrombosis and venous reflux.
Peritonitis: signs and symptoms. Clinical and instrumental diagnostics.
Clinical and instrumental semiology of intestinal occlusions.
Clinical and instrumental semiotics of the upper G.I. tract
Semiology of the brest
Teaching methods
Teaching will be delivered through lectures. The teaching material will be available on the Ariel website of the University
Teaching Resources
Chirurgia Generale- F. Minni - CEA ed. ISBN : 978-8808320490, Gennaio 2019
Sabiston- Trattato di Chirurgia 20° edizione - EDRA ed.. ISBN : 978-8821446917, Marzo 2019
Pathology
Course syllabus
Introduction to Anatomic Pathology

General principles of histopathology, cytopathology and autopsies.
Ancillary techniques in anatomic pathology (immunohistochemistry, FISH and others molecular techniques)
General principles of diagnostic histopathology (pathological growth: metaplasia, dysplasia; tumor grading, tumor staging; the pathology report; prognostic and predictive markers)


Cardiovascular pathology

Pathology of the vessels: Arteriosclerosis, Atherosclerosis, Aneurysms and Dissection, Vascular Tumors
Heart Failure
Congenital Heart Disease
Ischemic Heart Disease
Valvular Heart Disease
Cardiomyopathies
Pericardial Disease
Cardiac Transplantation

Pathology of the lung and pleura

Congenital Anomalies, Atelectasis (Collapse), Pulmonary Edema
Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage)
Obstructive and Restrictive Lung Diseases
Chronic Diffuse Interstitial (Restrictive) Diseases
Pulmonary Infections
Lung Transplantation
Tumors of the lung
Pleural Effusion
Pleural Tumors
Teaching methods
Lectures
Teaching Resources
Robbins and Cotran. PATHOLOGIC BASIS OF DISEASE (9th Edition)
Urology
Course syllabus
Urological semeiotics
Andrological semeiotics
Haematuria
Kidney tumors
Prostate cancer
Bladder tumors
Testicular tumors
BPH
Urinary incontinence
Genitourinary infections
Urinary lithiasis
Infertility and varicocele
Erectile disfunction
Andrological urgencies
Uro-andrological traumatology
Teaching methods
Teaching will take advantage of:
- Formal lessons with the support of slides and/or videos
- Practical excercises on the patients: gathering medical history, physical examination, small interventions (e.g.urethral calibration, bladder washing, bladder catheterization)
- participation as bystanders in small groups in highly specialized maneuvers (cystoscopies and bladder biopsies, ultrasound and prostate biopsies, urological surgical procedures)
Teaching Resources
- Harrison' s principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018) con specifico riferimento ai capitoli dedicati alla patologia urologica
- Urologia (Francesco Porpiglia e coll.) Edizioni Minerva Medica - 2015
The most up-to-date bibliographical entries on the topics covered will be provided annually, with preferential reference to original articles and/or revisions recently published in high-impact scientific journals
Cardiovascular diseases
MED/11 - CARDIOVASCULAR DISEASES - University credits: 5
Informal teaching: 16 hours
Lessons: 48 hours
General surgery
MED/18 - GENERAL SURGERY - University credits: 1
Lessons: 12 hours
Professor: Bonavina Luigi
Internal medicine
MED/09 - INTERNAL MEDICINE - University credits: 1
Lessons: 12 hours
Professor: La Mura Vincenzo
Medical genetics
MED/03 - MEDICAL GENETICS - University credits: 1
Lessons: 12 hours
Professor: Ghezzi Daniele
Nephrology
MED/14 - NEPHROLOGY - University credits: 4
Informal teaching: 16 hours
Lessons: 36 hours
Professors: Alfieri Carlo Maria, Messa Piergiorgio
Pathology
MED/08 - PATHOLOGY - University credits: 2
Lessons: 24 hours
Professor: Viale Giuseppe
Respiratory diseases
MED/10 - RESPIRATORY DISEASES - University credits: 4
Informal teaching: 16 hours
Lessons: 36 hours
Professor: Valenti Vincenzo
Urology
MED/24 - UROLOGY - University credits: 1
Lessons: 12 hours

Linea: San Giuseppe

Responsible
Lectures will still take place in classrooms, if students can't reach the buildings we might consider alternative ways.
Prerequisites for admission
Propedeutical courses for Systems and Diseases I include: General Pathology and Physiopathology (compulsory), Human Physiology (compulsory).
For the module of Medical Genetics, the basic knowledge presented in the course of Biology and genetics is expected to be assimilated.
Assessment methods and Criteria
At the end of the course, an oral examination is performed; the test is based on an oral question by at least two teachers responsible for different modules (about 15-20 minutes for each teacher).
During the test, the following elements are evaluated: knowledge of the topics presented during the course, ability of critical reasoning on the study carried out; clarity of the oral presentation and the correct use of specialized lexicon. After collective evaluation of the teachers involved in the exam, the mark is expressed in thirtieths.
Medical genetics
Course syllabus
Rare diseases: diffusion, diagnostic difficulties and new approaches (Next Generation Sequencing): Analysis of panels, clinical exome and whole exome. Notes on the evaluation of gene variants
Dysmorphology: study of the main dysmorphic features. Definitions
Genetic risk factors for male infertility: Chromosomal abnormalities (Klinefelter syndrome, Microdeletions of the Y chromosome); Monogenic diseases (CFTR, AR);
Hereditary cardiomyopathies: Molecular approach for the diagnosis of hereditary heart diseases. Genetic basis of hypertrophic cardiomyopathies; Arrhythmogenic cardiomyopathies; Dilated cardiomyopathies and muscular dystrophies; Non-compaction of left ventricle; Cardiac channelopathies (e.g. long QT and Brugada syndromes). Genetic cardiac malformations with exemplary diseases: Down syndrome and s. DiGeorge / deletion 22q11.2); RASopathies (Noonan and related syndromes).
Teaching methods
Frontal lesson
Teaching Resources
Genetics in Medicine", Thompson &Thompson; durante le lezioni e sul sito Ariel, vengono inoltre indicate pubblicazioni (articoli, reviews) di approfondimento. Infine vengono fornite le presentazioni utilizzate durante le lezioni.
Internal medicine
Course syllabus
History taking
General physical examination
Main signs and symptoms
Physical examination of the Thorax, chest and cardiovascular system (Inspection, palpation, percussion, auscultation) - Physical examination of the abdomen and main clinical pictures of the liver, spleen and pancreas (Inspection, palpation, percussion, auscultation) and main diagnostic approach to exams
Teaching methods
Teaching will be delivered through lectures. The teaching material will be available on the Ariel website of the University
Teaching Resources
Harrison's, Principles of Internal Medicine, 21th ed, McGraw-Hill international, (also available as ebook in the digital library of the University of Milano)
Lynn Bickley. Bates' Physical examination and history taking. Lippincott
Respiratory diseases
Course syllabus
1st part:
· Medical Hystory and respiratory physical examination
· Principles of radiological diagnosis
· Principles of respiratory pathophysiology
· Principles of acid base balance
·
2st part:
· Chronic Obstructive Pulmonary Disease (COPD)
· Astma
· Pulmonary tuberculosis and atypical mycobacteriosis
· Cystic Fibrosis in Adults
· Non tuberculous lung infections
· Lung cancer
· Mediastinal tumor
· Tumor of the pleura
· Non tumoral pleural diseases
· Acute and chronic respiratory failure
· Pulmonary Hypertension
· Pulmonary embolism
Teaching methods
Final oral exam: questions on the contents of particular clinical and pathophysiological relevance relating to the topics covered and resolution of clinical cases
The final test results will be communicated to the end of the exam completion to each individual learner
Teaching Resources
Harrison 's principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018)
With specific reference to the chapters dedicated to respiratory pathology
The most updated bibliographic entries relating to the topics will be provided annually, preferentially referring to original articles and / or revisions recently published in high-impact scientific journals
Cardiovascular diseases
Course syllabus
-Cardiovascular risk stratification.
-Ischemic heart disease
-Chest pain management
-Hypertension
-Aortic and mitral valve disease
-Electrocardiography
-Echocardiography
-Heart failure
-Cardiac arrhythmias
-Mio-pericarditis
-Cardiomyopaties
-Congenital heart disease
-Pulmonary hypertension
Teaching methods
Oral lessons (48 hours)
Non-frontal lessons (12 hours)
Practical tutorials
Teaching Resources
Harrison. Principles of Internal Medicine

di Dennis L. Kasper, Anthony S. Fauci, Dan L. Longo
Nephrology
Course syllabus
1st part:
· Notes on renal anatomy and physiology
· Main symptoms related to kidney diseases
· Evaluation of glomerular function
· Evaluation of tubular function
· Evaluation of renal endocrine function
· Pathogenesis of oedema of renal origin
· Water and electrolyte disturbances
· Nephrological syndromes
· glomerular diseases & vasculitides
· Renal genetic diseases (ADPKD)
· Tubulo-interstitial diseases
UTI
nephrolithiasis

2nd part:
· Renal diseases secondary to systemic diseases
diabetes
neoplasia
· Vascular renal diseases
Atherosclerotic
Hypertensive nephropathy/Nephroangio-sclerosis
· AKI: causes and diagnosis
· CKD: complications and progression
· Notes on the substitutive therapies of ESRD
Teaching methods
Teaching will take advantage of:
- Formal lessons with the support of slides and/or videos
- Practice exercises in small groups on clinical cases and/or queries on clinical conditions commonly found in the nephrology field
- Practical excercises on the patients: gathering medical history, physical examination, small interventions (e.g. blood sampling, bladder catheterization)
- Renal ultra-sound evaluation; microscopic examination of urinary sediment and of the renal tissue obtained by renal biopsy
- participation as bystanders in small groups in highly specialized maneuvers (interventions of central venous catheterization, accomplishment of hemodialysis or peritoneal dialysis accesses, renal biopsies)
- visit in small groups to the renal research laboratory
Teaching Resources
Harrison' s principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018)
With specific reference to the chapters dedicated to renal disease
The most up-to-date bibliographical entries on the topics covered will be provided annually, with preferential reference to original articles and/or revisions recently published in high-impact scientific journals
General surgery
Course syllabus
General semiology of the abdomen.
General semiology of diseases of the lower limbs of vascular origin. Arteriosclerosis. Venous thrombosis and venous reflux.
Peritonitis: signs and symptoms. Clinical and instrumental diagnostics.
Clinical and instrumental semiology of intestinal occlusions.
Clinical and instrumental semiotics of the upper G.I. tract
Semiology of the brest
Teaching methods
Teaching will be delivered through lectures. The teaching material will be available on the Ariel website of the University
Teaching Resources
Chirurgia Generale- F. Minni - CEA ed. ISBN : 978-8808320490, Gennaio 2019
Sabiston- Trattato di Chirurgia 20° edizione - EDRA ed.. ISBN : 978-8821446917, Marzo 2019
Pathology
Course syllabus
Introduction to Anatomic Pathology

General principles of histopathology, cytopathology and autopsies.
Ancillary techniques in anatomic pathology (immunohistochemistry, FISH and others molecular techniques)
General principles of diagnostic histopathology (pathological growth: metaplasia, dysplasia; tumor grading, tumor staging; the pathology report; prognostic and predictive markers)


Cardiovascular pathology

Pathology of the vessels: Arteriosclerosis, Atherosclerosis, Aneurysms and Dissection, Vascular Tumors
Heart Failure
Congenital Heart Disease
Ischemic Heart Disease
Valvular Heart Disease
Cardiomyopathies
Pericardial Disease
Cardiac Transplantation

Pathology of the lung and pleura

Congenital Anomalies, Atelectasis (Collapse), Pulmonary Edema
Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage)
Obstructive and Restrictive Lung Diseases
Chronic Diffuse Interstitial (Restrictive) Diseases
Pulmonary Infections
Lung Transplantation
Tumors of the lung
Pleural Effusion
Pleural Tumors
Teaching methods
Lectures
Teaching Resources
Robbins and Cotran. PATHOLOGIC BASIS OF DISEASE (9th Edition)
Urology
Course syllabus
Urological semeiotics
Andrological semeiotics
Haematuria
Kidney tumors
Prostate cancer
Bladder tumors
Testicular tumors
BPH
Urinary incontinence
Genitourinary infections
Urinary lithiasis
Infertility and varicocele
Erectile disfunction
Andrological urgencies
Uro-andrological traumatology
Teaching methods
Teaching will take advantage of:
- Formal lessons with the support of slides and/or videos
- Practical excercises on the patients: gathering medical history, physical examination, small interventions (e.g.urethral calibration, bladder washing, bladder catheterization)
- participation as bystanders in small groups in highly specialized maneuvers (cystoscopies and bladder biopsies, ultrasound and prostate biopsies, urological surgical procedures)
Teaching Resources
- Harrison' s principles of internal medicine (Harrison - Jameson - Loscalzo - Fauci - Kasper - Hauser - Longo, edition 2018) con specifico riferimento ai capitoli dedicati alla patologia urologica
- Urologia (Francesco Porpiglia e coll.) Edizioni Minerva Medica - 2015
The most up-to-date bibliographical entries on the topics covered will be provided annually, with preferential reference to original articles and/or revisions recently published in high-impact scientific journals
Cardiovascular diseases
MED/11 - CARDIOVASCULAR DISEASES - University credits: 5
Informal teaching: 16 hours
Lessons: 48 hours
Professor: Andreini Daniele
General surgery
MED/18 - GENERAL SURGERY - University credits: 1
Lessons: 12 hours
Professor: Favi Evaldo
Internal medicine
MED/09 - INTERNAL MEDICINE - University credits: 1
Lessons: 12 hours
Medical genetics
MED/03 - MEDICAL GENETICS - University credits: 1
Lessons: 12 hours
Nephrology
MED/14 - NEPHROLOGY - University credits: 4
Informal teaching: 16 hours
Lessons: 36 hours
Pathology
MED/08 - PATHOLOGY - University credits: 2
Lessons: 24 hours
Professor: Pelosi Giuseppe
Respiratory diseases
MED/10 - RESPIRATORY DISEASES - University credits: 4
Informal teaching: 16 hours
Lessons: 36 hours
Urology
MED/24 - UROLOGY - University credits: 1
Lessons: 12 hours
Professor: Guarneri Andrea
Professor(s)
Reception:
IRCCS MultiMedica
Monday 12 AM - 01 PM
Reception:
14.00-15.00
Studio Medici U.O.C. Trapianti di Rene - Padiglione Croff - Ospedale Maggiore Policlinico
Reception:
appointment to be agreed by e-mail
Reception:
For an appointment please send an email
Nephrology and Dialysis Units of Sacco hospital or Fatebenefratelli hospital
Reception:
by telephone appointment
via L. Temolo 4, 20126 Milano - Lab of Neurogenetics and mitochondrial disorders
Reception:
Monday 12.00-13.00 (by appointment)
Interhospital Pathology Division, Science and Technology Park, Via Fantoli 16/15, 20138 Milano
Reception:
Available on request
RCCS Ca' Granda - Ospedale Maggiore Policlinico - Pad. Invernizzi - 5th floor, wing B