System Medicine

Doctoral programme (PhD)
A.Y. 2020/2021
Study area
Medicine and Healthcare
The Medicine field is going through a cultural revolution, pressed by the new knowledge emerging from the fundamental biology (molecular biology, and, more recently, genomics). This knowledge has brought to the development of the Personalized Medicine, based on the identification of the mechanisms in the disease, specific to the given disease and to the patient, and the consequent molecular treatments. Although the Personalized Medicine changed the story of some diseases, for some others there exists a rising discrepancy between the scientific discoveries and their turning into a benefit for the patient. This discrepancy is considered a problem by both the scientific community and the society. The aim of the PhD course is the training of a new generation of basic researchers, able to follow the changes occurring in the biomedicine.
The fundamental elements of the training program are:
· the introduction of basic subjects (mathematics, physics, informatics, statistics);
· the teaching of new models of Translational Research, where the basic researchers work along with the clinicians on the same biomedical problems;
· the foundation of a humanistic culture of the new scientific discoveries (foundational, ethical and sociological basis) and the operative tools (cognitive sciences) which allow the new scientists to interact with the society (patients, policy-makers).
The fundamental elements of the training program are:
· the introduction of basic subjects (mathematics, physics, informatics, statistics);
· the teaching of new models of Translational Research, where the basic researchers work along with the clinicians on the same biomedical problems;
· the foundation of a humanistic culture of the new scientific discoveries (foundational, ethical and sociological basis) and the operative tools (cognitive sciences) which allow the new scientists to interact with the society (patients, policy-makers).
Tutte le classi di laurea magistrale - All classes of master's degree
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
- Main offices
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano - Degree course coordinator: Giuseppe Viale
[email protected] - Degree course website
http://www.semm.it/education
Title | Professor(s) |
---|---|
Understanding the molecular role of tumor BRCA suppressor genes
Curriculum: Molecular Oncology |
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The role of DNA repair and DNA damage response proteins in vertebrate stem cells, embryonic development and cancer
Curriculum: Molecular Oncology |
|
Molecular mechanisms ensuring genome stability altered in cancer and stem cells
Curriculum: Molecular Oncology |
|
Metabolismo del DNA
Curriculum: Molecular Oncology |
|
How organelle communication regulates EGFR endocytosis and signaling: relevance to physiology and cancer
Curriculum: Molecular Oncology |
|
Endocytosis, signaling and cancer
Curriculum: Molecular Oncology |
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Role of Epsin3-mediated endocytosis in cell plasticity, breast cancer progression and metastasis
Curriculum: Molecular Oncology |
|
Molecular and structural investigation of the p53 regulatory pathway mediated by the numb isoforms
Curriculum: Molecular Oncology |
|
Upstream and downstream mechanisms linked to the loss of the tumor suppressive function of Numb in bladder carcinogenesis: therapeutic and clinical implications
Curriculum: Molecular Oncology |
|
Upstream and downstream mechanisms linked to the loss of the tumor suppressive function of Numb in bladder carcinogenesis: therapeutic and clinical implications
Curriculum: Molecular Oncology |
|
Shaping of iNKT cells cytotoxic functions during CRC progression
Curriculum: Molecular Oncology |
F. Facciotti
|
Mucosal immunology
Curriculum: Molecular Oncology |
F. Facciotti
|
Role of IL-10 producing regulatory T-cells in cancer
Curriculum: Molecular Oncology |
|
Regulatory and helper T-cell subsets in health and disease
Curriculum: Molecular Oncology |
|
Mechanisms controlling morphology of neural progenitor cells during brain development
Curriculum: Molecular Oncology |
N. Kalebic
|
Molecular mechanisms underlying brain development and evolution
Curriculum: Molecular Oncology |
N. Kalebic
|
Clonal tracking in vivo in melanoma patient-derived xenografts
Curriculum: Molecular Oncology |
L. Lanfrancone
|
Modeling and Targeting Metastatic Cancer in vivo and in vitro
Curriculum: Molecular Oncology |
L. Lanfrancone
|
Metabolic and epigenetic control of innate immunity in cancer
Curriculum: Molecular Oncology |
L. Mazzarella
|
Predictors of response to combined immunological + epigenetic therapy
Curriculum: Computational Biology |
L. Mazzarella
|
Machine learning-based methods for interpreting cancer-associated germline and somatic variants
Curriculum: Computational Biology |
L. Mazzarella
|
Integration of transcriptional and metabolic control in inflammatory responses
Curriculum: Molecular Oncology |
G. Natoli
|
Transcriptional Control in Inflammation and Cancer
Curriculum: Molecular Oncology |
G. Natoli
|
Noncoding RNA Mechanisms involved in transcriptional and epigenetic plasticity of cancer cells
Curriculum: Molecular Oncology |
F. Nicassio
|
Detection and quantification of RNA profiles and RNA modifications from Nanopore direct RNA sequencing data in human disease
Curriculum: Computational Biology |
F. Nicassio
|
Noncoding Genome in Development and Disease
Curriculum: Computational Biology |
F. Nicassio
|
Noncoding Elements and Transcriptional plasticity in advanced cancer
Curriculum: Molecular Oncology |
F. Nicassio
|
Exploring molecular and cellular mechanisms of cancer progression and metastases
Curriculum: Molecular Oncology |
|
Phenotypic and functional adaptation of cancer cells to the tumor microenvironment as a leading cause of metastatic dissemination
Curriculum: Molecular Oncology |
|
Role of asymmetric/symmetric division in normal and cancer stem cells
Curriculum: Molecular Oncology |
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Analyses of the genetic and phenotypic evolution at single-cell level of normal and cancer stem cells
Curriculum: Computational Biology |
|
EV-based liquid biopsy in Glioblastoma
Curriculum: Molecular Oncology |
|
Multimodel approach on risk factors and management of cardiotoxicity in cancer patients
Curriculum: Medical Humanities |
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Clinical Decision Support system for data interpretation and shared decision-making in oncology
Curriculum: Medical Humanities |
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Modelling shared decision making in health care
Curriculum: Medical Humanities |
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Developing integrated health behavioural models to prevent cancer disease
Curriculum: Medical Humanities |
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Tumor ecosystem evolution
Curriculum: Computational Biology |
M. Schaefer
|
Detection of causative cancer drivers beyond point mutations
Curriculum: Computational Biology |
M. Schaefer
|
Microenvironmental exposure and tumor evolution
Curriculum: Computational Biology |
M. Schaefer
|
Computational cancer biology
Curriculum: Computational Biology |
M. Schaefer
|
Organoid-based single cell deconvolution of the health impact of endocrine disruptors
Curriculum: Molecular Oncology |
|
Single-cell-omic deconvolution of druggable circuits in patient-derived ovarian cancer organoids
Curriculum: Molecular Oncology |
|
Epigenetic dysregulation in Weaver syndrome: single-cell-omic deconvolution in patient-specific brain organoids
Curriculum: Molecular Oncology |
|
Single-cell multi-omics deconvolution of neurodevelopmental disorders
Curriculum: Computational Biology |
|
Stem Cell and Organoid Epigenetics
Curriculum: Molecular Oncology |
|
Epigenetics of Weaver syndrome
Curriculum: Molecular Oncology |
|
Solid-to-liquid-like transition during cancer progression
Curriculum: Molecular Oncology |
|
Mechanisms of Tumor Cell Migration
Curriculum: Molecular Oncology |
|
Structural and functional role of TFIIIC in genome architecture
Curriculum: Molecular Oncology |
A. Vannini
|
Structural studies of protein complexes associated with intellectual disabilities and cancer
Curriculum: Molecular Oncology |
A. Vannini
|
Study of Ezrin\TSC\mTORC1 pathway in retina: a new therapeutic target to treat retinal degeneration
Curriculum: Human Genetics |
A. Auricchio
|
AAV-mediated genome editing for therapy of inherited blindness and of lysosomal storage diseases
Curriculum: Human Genetics |
A. Auricchio
|
Gene Therapy of Severe Inherited Photoreceptor Diseases
Curriculum: Human Genetics |
A. Auricchio
|
Elucidating the mechanisms underlying kidney cystogenesis and tumorigenesis
Curriculum: Human Genetics |
A. Ballabio
|
Transcriptional regulation of autophagy and lysosomal function
Curriculum: Human Genetics |
A. Ballabio
|
Development of novel therapies for inborn errors of metabolism
Curriculum: Human Genetics |
N. Brunetti-Pierri
|
New therapies for inborn errors of metabolism
Curriculum: Human Genetics |
N. Brunetti-Pierri
|
Cloud computing for high-throughput genomics applications
Curriculum: Human Genetics |
D. Cacchiarelli
|
Genomic medicine
Curriculum: Human Genetics |
D. Cacchiarelli
|
Understanding and treating neurodegeneration in lysosomal storage diseases
Curriculum: Human Genetics |
A. Fraldi
|
Molecular Theraphy
Curriculum: Human Genetics |
A. Fraldi
|
Investigation of the role of tmem175 in lysosomal and autophagic pathways
Curriculum: Human Genetics |
D. Medina
|
Cell Biology and desease Mechanisms
Curriculum: Human Genetics |
D. Medina
|
One gene several diseases: why and how?
Curriculum: Human Genetics |
B. Franco
|
Can down regulation of miR181 be beneficial in Friedreich Ataxia?
Curriculum: Human Genetics |
B. Franco
|
Cilia and Human Diseases
Curriculum: Human Genetics |
B. Franco
|
Tracking the intracellular trafficking pathways of structural proteins of SARS-COVs
Curriculum: Human Genetics |
A. De Matteis
|
Kidney Organoids for the Modeling of inherited renal diseases
Curriculum: Human Genetics |
A. De Matteis
|
Signaling in membrane trafficking
Curriculum: Human Genetics |
A. De Matteis
|
Role of ionocytes in the the physiology of the airway epithelium
Curriculum: Human Genetics |
L. Galieta
|
Pharmacological modulation of ion transport to treat the basic defect in cystic fibrosis and other genetic diseases
Curriculum: Human Genetics |
L. Galieta
|
Translational studies to impair breast cancer metabolism: a focus on TNBC
Curriculum: Molecular Oncology |
M. Zollo
|
Courses list
January 2021
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Biochemistry and Molecular Biology Techniques | 4 | 20 | English |
February 2021
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Cancer Genetics | 2 | 10 | English | |
Genomics and Proteomics | 5 | 25 | English | |
Scientific Writing | 2 | 10 | English |
February 2021
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Genomics and Proteomics | 5 | 25 | English | |
Scientific Writing | 2 | 10 | English |
February 2021
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Scientific Writing | 2 | 10 | English |
January 2021
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Introduction to Bioethics | 6 | 30 | English |
February 2021
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Scientific Writing | 2 | 10 | English |
Not specified period
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Communication in Medicine | 2 | 10 | English | |
Principles and Practice of Structural Equation Modeling | Monzani Dario
|
4 | 20 | Italian |
Following the programme of study
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