System medicine

Dottorati
Doctoral programme (PhD)
A.Y. 2021/2022
Study area
Medicine and Healthcare
Inter-university
Università degli Studi di Napoli Federico II
Doctoral programme (PhD)
4
Years
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
English
PhD Coordinator
The Medicine field is going through a cultural revolution, pressed by the new knowledge emerging from the fundamental biology (molecular biology, and, more recently, genomics). This knowledge has brought to the development of the Personalized Medicine, based on the identification of the mechanisms in the disease, specific to the given disease and to the patient, and the consequent molecular treatments. Although the Personalized Medicine changed the story of some diseases, for some others there exists a rising discrepancy between the scientific discoveries and their turning into a benefit for the patient. This discrepancy is considered a problem by both the scientific community and the society. The aim of the PhD course is the training of a new generation of basic researchers, able to follow the changes occurring in the biomedicine.

The fundamental elements of the training program are:

· the introduction of basic subjects (mathematics, physics, informatics, statistics);
· the teaching of new models of Translational Research, where the basic researchers work along with the clinicians on the same biomedical problems;
· the foundation of a humanistic culture of the new scientific discoveries (foundational, ethical and sociological basis) and the operative tools (cognitive sciences) which allow the new scientists to interact with the society (patients, policy-makers).
Tutte le classi di laurea magistrale - All classes of master's degree
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
Title Professor(s)
Dissecting the epigenetic role of Transposable Elements in tumor infiltrating lymphocytes
Curriculum: Molecular Oncology
Tissue infiltrating T lymphocytes in health and disease: new approaches to dissect identity, geography and function of tissutal T cells and to discover new targets for precision immunotherapy
Curriculum: Molecular Oncology
Evaluation of the risk of secondary leukemias in cancer survivors
Curriculum: Molecular Oncology
Functional Genomics
Curriculum: Molecular Oncology
Combinatorial targeting of MYC- and BCL2-driven lymphoma
Curriculum: Molecular Oncology
B. Amati
Oncogenes, Transcription and Cancer
Curriculum: Molecular Oncology
B. Amati
Proteomics elucidation of tumor microenvironment
Curriculum: Molecular Oncology
A. Bachi
Functional Proteomics
Curriculum: Molecular Oncology
A. Bachi
Epi-proteomics approach to investigate the role of protein-post translational modifications in tumorigenesis, chemoresistance and latency
Curriculum: Molecular Oncology
Nuclear Proteomics to Study Gene Expression Regulation in Cancer
Curriculum: Molecular Oncology
An integrative analysis framework between RNA synthesis and decay.
Curriculum: Computational Biology
L. Calviello
RNP dynamics along the mRNA in normal and mis-regulated translation.
Curriculum: Computational Biology
L. Calviello
Characterizing the role of heterogeneous RNPs and their dynamics along the mRNA
Curriculum: Computational Biology
L. Calviello
Proteogenomics applications between RNA and protein
Curriculum: Computational Biology
L. Calviello
Regulation of chromatin activity by interactome with non-coding RNA classes
Curriculum: Computational Biology
P. Carninci
Functional Genomics
Curriculum: Computational Biology
P. Carninci
Molecular Mechanisms of mRNA Modifying Machines
Curriculum: Molecular Oncology
A. Casanal
RNA modifications and their role
Curriculum: Molecular Oncology
A. Casanal
Thyroid Biology
Curriculum: Molecular Oncology
F. Coscia
Structural and functional characterisation of thyroid proteins involved in cancer, autoimmunity and hormone synthesis defects
Curriculum: Molecular Oncology
F. Coscia
Understanding how vertebrate stem cells maintain genome stability
Curriculum: Molecular Oncology
The role of DNA repair and DNA damage response proteins in vertebrate stem cells, embryonic development and cancer
Curriculum: Molecular Oncology
Exploring the links between cancer and stem cells
Curriculum: Molecular Oncology
DNA Methabolism
Curriculum: Molecular Oncology
Aging as a telomere biology disorder
Curriculum: Molecular Oncology
F. D'Adda di Fagagna
DNA damage Response and Cellular Senescence
Curriculum: Molecular Oncology
F. D'Adda di Fagagna
Deciphering patterns of genetic convergence disrupting human brain development via integrative single-cell multi-omics
Curriculum: Computational Biology
J. Davila-Velderrain
Cellular complexity of the human brain in development and neurodegeneration
Curriculum: Computational Biology
J. Davila-Velderrain
Endocytosis, signaling and cancer
Curriculum: Molecular Oncology
Endocytosis, cancer stem cells and metastasis
Curriculum: Molecular Oncology
Molecular and structural investigation of the p53 regulatory pathway mediated by the numb isoforms
Curriculum: Molecular Oncology
Modelling bacterial and viral infections in organoids using cryo-electron tomography
Curriculum: Molecular Oncology
P. Erdmann
The Development of a Novel Human Pluripotent Stem Cell-Based Organoid System to Study Host-Virus interactions in the Central Nervous System
Curriculum: Molecular Oncology
O. Harschnitz
Neuroimmunological disorders
Curriculum: Molecular Oncology
O. Harschnitz
Molecular and cellular mechanisms that underlie susceptibility to viral and autoimmune disease of the human nervous system
Curriculum: Molecular Oncology
O. Harschnitz
Dissection of Acute and Chronic Pathology in Autoimmune Encephalitis Using a Highly Defined Human Stem Cell-Derived Co-Culture System
Curriculum: Molecular Oncology
O. Harschnitz
Delineating the landscape of glioblastoma vulnerabilities from the analysis of single-cell omics and Cancer Dependency Map data.
Curriculum: Computational Biology
F. Iorio
Analytical methods for pharmacogenomics
Curriculum: Computational Biology
F. Iorio
Morphology of neural progenitor cells in brain development and neurodevelopmental disorders
Curriculum: Molecular Oncology
N. Kalebic
Molecular mechanisms underlying brain development and evolution
Curriculum: Molecular Oncology
N. Kalebic
Nutrition based methods to identify and enhance targeted cancer therapies
Curriculum: Molecular Oncology
V. Longo
Longevity and Cancer
Curriculum: Molecular Oncology
V. Longo
Nutrition and cancer
Curriculum: Molecular Oncology
V. Longo
Transcription stress and metabolic redesign in rare DNA Repair disorders
Curriculum: Molecular Oncology
P. G. Mastroberardino
Impact of systemic metabolism antitumoral immunity
Curriculum: Molecular Oncology
L. Mazzarella
Translational oncology
Curriculum: Molecular Oncology
L. Mazzarella
Genetic and biophysical determinants of breast cancer metastasis and sensitivity to novel drugs
Curriculum: Molecular Oncology
L. Mazzarella
Methabolism and cancer
Curriculum: Molecular Oncology
L. Mazzarella
The dynamics of the epigenome and adaptation to therapy
Curriculum: Computational Biology
Epigenome and cancer
Curriculum: Computational Biology
The intersection of metabolic adaptations of tumor cells and the regulation of the epigenome
Curriculum: Molecular Oncology
Chromatin Alterations in Tumorigenesis
Curriculum: Molecular Oncology
Characterization of genomic regulatory elements in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML)
Curriculum: Molecular Oncology
Transcriptional Control in Inflammation and Cancer
Curriculum: Molecular Oncology
The role of non-coding genome in cancer disease
Curriculum: Molecular Oncology
F. Nicassio
Noncoding Genome in Development and Disease
Curriculum: Molecular Oncology
F. Nicassio
Mechanistic understanding of Polycomb-mediated regulation of transcriptional identity in oncogenesis
Curriculum: Molecular Oncology
Epigenetic Mechanisms in Cancer
Curriculum: Molecular Oncology
Exploring molecular and cellular mechanisms of cancer progression and metastases
Curriculum: Molecular Oncology
Molecular mechanisms of tumorigenesis
Curriculum: Molecular Oncology
Molecular mechanisms of tumorigenesis from a computational point of view
Curriculum: Computational Biology
Analyses of the genetic and phenotypic evolution at single-cell level of normal and cancer stem cells
Curriculum: Computational Biology
Development of artificial intelligence for multi-parametric MRI of prostate
Curriculum: Computational Biology
Three-dimensional prostate model use and augmented-reality during robot-assisted radical prostatectomy
Curriculum: Computational Biology
Enhancing adherence to behavioral change recommendations and medications among cancer survivors
Curriculum: Medical Humanities
Psycho-social behavior and immune system: DeveIoping an integrated model of care
Curriculum: Medical Humanities
Developing integrated health behavioural models to prevent cancer disease
Curriculum: Medical Humanities
Effects of adjuvant endocrine therapy on cognitive performance in patients with breast cancer: a longitudinal study
Curriculum: Medical Humanities
Healthy aging and the human microbiome
Curriculum: Computational Biology
N. Segata
Cardiometabolic risk in an Italian population
Curriculum: Computational Biology
N. Soranzo
Molecular and genetic control of T cell - B cell interaction and antibody production
Curriculum: Computational Biology
B. Soskic
Variation in the immune system
Curriculum: Computational Biology
B. Soskic
Computational Methods for Single-Cell Cancer Evolution
Curriculum: Computational Biology
A. Sottoriva
Predicting cancer evolution
Curriculum: Computational Biology
A. Sottoriva
Studying the role of intracellular traffic in brain development using cell biology and robotics
Curriculum: Molecular Oncology
E. Taverna
Stem cell identity in brain development
Curriculum: Molecular Oncology
E. Taverna
Organoid-based single cell deconvolution of the health impact of endocrine disruptors
Curriculum: Molecular Oncology
Neurodevelopmental and intergenerational impact of endocrine disruptors
Curriculum: Molecular Oncology
Deep learning approaches to data integration and multi-omic lineage tracing in ovarian cancer
Curriculum: Computational Biology
Single-cell multi-omics deconvolution of neurodevelopmental disorders
Curriculum: Computational Biology
Stem Cell and Organoid Epigenetics
Curriculum: Molecular Oncology
Human brain evolution through the lens of neurodevelopmental disorders
Curriculum: Molecular Oncology
Studying architectural proteins of the human genome by cryo-EM
Curriculum: Molecular Oncology
A. Vannini
Structural studies of protein complexes associated with intellectual disabilities and cancer
Curriculum: Molecular Oncology
A. Vannini
TFEB-mTORC1 signaling in health and disease
Curriculum: Human Genetics
A. Ballabio
Transcriptional regulation of autophagy and lysosomal function
Curriculum: Human Genetics
A. Ballabio
Therapeutic genome editing in retina and liver
Curriculum: Human Genetics
A. Auricchio
Study of Ezrin\TSC\mTORC1 pathway in retina: a new therapeutic target to treat retinal degeneration
Curriculum: Human Genetics
A. Auricchio
The OFD1 transcript:one gene, several disease
Curriculum: Human Genetics
B. Franco
Can down regulation of miR181 be beneficial in Friedreich Ataxia?
Curriculum: Human Genetics
B. Franco
New therapies for inborn errors of liver metabolism
Curriculum: Human Genetics
N. Brunetti Pierri
Development of novel therapies for inborn errors of metabolism
Curriculum: Human Genetics
N. Brunetti Pierri
Gut Microbiome as target for innovative preventive and therapeutic strategies for chronic non-communicable disorders
Curriculum: Human Genetics
R. Berni Canani
Formulated milk administration to children and their hereditary disorders
Curriculum: Human Genetics
R. Berni Canani
Emerging metabolites and enzymes in mammalian central nervous system
Curriculum: Molecular Oncology
A. Usiello
F. Salvatore
Predictive medicine for tumors with their physiopatological molecular aspects
Curriculum: Molecular Oncology
F. Salvatore

Courses list

January 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Biochemistry and molecular biology techniques 4 20 English
February 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Cancer Genetics
2 10 English
Scientific Writing 2 10 English
February 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Genomics and Proteomics 5 25 English
Scientific Writing 2 10 English
February 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Scientific Writing 2 10 English
February 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Scientific Writing 2 10 English
May 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Introduction to quatitative data analysis with SPSS 6 30 English

Enrollment

Application for admission: please refer to the call

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